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Shouan Zhu, PhD

Shouan Zhu 8-2020
Assistant Professor; Investigator of the Ohio Musculoskeletal & Neurological Institute
Life Science Building 135, Athens Campus
Biomedical Sciences
Diabetes Institute
Ohio Musculoskeletal and Neurological Institute


  • Aging and Metabolism, Oklahoma Medical Research Foundation (Postdoc), 2020
  • Orthopedics research, Johns Hopkins University (Postdoc), 2017
  • Orthopedics research, Johns Hopkins University (PhD, 4, 5 year), 2016
  • Stem cell and regenerative medicine (PhD, 1, 2, 3 year), Zhejiang University, 2014

Summary of Work: 

We are studying how osteoarthritis (OA) occurs with different risk factors, such as aging and obesity, with particular interests in studying the role of cellular metabolism in OA pathogenesis.

Our recent findings demonstrate that one type of protein post-translational modification-lysine malonylation (MaK) is increased during aging and obesity and promotes chondrocyte metabolic dysfunction. Additionally, the demalonylase SIRT5 decreases in cartilage during aging. The current active research projects in lab include: 1. Studying how an aging-dependent decline of Sirt5 promotes MaK and chondrocyte metabolic dysfunction; 2. Studying how MaK is accumulated in cartilage during obesity.


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