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Brian Clark, PhD

Clark, Brian 11-21
Prof., Physiology & Neuroscience; Osteopathic Heritage Foundation Harold E. Clybourne, D.O., Endowed Research Chair
Irvine 250, Athens Campus


  • Neuromuscular Physiology (PhD), Syracuse University, 2006
  • Exercise Physiology (MS), Syracuse University, 2006
  • Gerontology (Certificate of Advanced Study), Syracuse University, 2006
  • Biology (BS), Western Carolina University, 1998

Summary of Work:

The overall goal of my research is to develop effective and implementable interventions that increase muscle function (e.g., muscle strength, motor control, fatigue-resistance) and mobility in older adults, and/or patients with orthopedic and neurologic disabilities. I have expertise and experience with basic and applied science human physiology experiments as well as randomized controlled trials. As such, my work is in the area of ‘translational physiology’, as it sits at the intersection of the bench and bedside. Within this scope, my laboratory maintains programmatic efforts in two focused areas: 1) the neuromuscular mechanisms of muscle weakness, fatigue-resistance, and mobility limitations, and 2) interventional strategies to enhance physical function and independence in older adults. Through strong collaborations I am also integrally involved in research and development that better understand the causes of musculoskeletal pain (e.g., low back pain) and injury as well as the development of non-surgical strategies to rehabilitate individuals suffering from musculoskeletal pain and injury. Lastly, I am also involved in efforts to develop novel technological approaches for studying neuromusculoskeletal health in humans (e.g., development of cortical bone mechanics technology that quantifies the mechanical properties of bone in vivo). Overall, my work seeks to improve the diagnosis, treatment, and prevention of musculoskeletal and neurological disorders, and the research across my respective foci has an overarching aim of developing interventions that remove barriers to independent physical mobility and ultimately reduce disability. My work has been continuously funded by more than $20M in extramural support by NIH, NASA, and various industry and non-profit sponsors. I have published more than 160 articles and chapters that have been extensively cited.