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Karen Coschigano, Ph.D.

Associate Professor

HCOM - Biomedical Sciences 
Academic Research Center 302D


Education:  Ph.D., Brandeis University, 1992


Research Interest:  


The main research focus of my laboratory is the identification of genes, proteins and regulatory pathways involved in the development of diabetic nephropathy, with an emphasis on the roles of growth hormone, signal transducer and activator of transcription 5 (STAT5), and inflammation.  My group uses mouse models, cell culture and molecular techniques, including microarray analyses and real-time RT/PCR.  We correlate changes in gene expression with changes in kidney function and histomorphometric parameters (the latter performed in collaboration with Dr. Ramiro Malgor, a colleague in my department).  We expect this knowledge to aid in the design of more specific, targeted markers and therapeutic approaches for the diagnosis, treatment or prevention of human diabetic kidney disease