A Novel and Efficacious Therapy for Human Liver Cancer
Human liver cancer is one of the most pharmacologically challenging cancer types with almost 700,000 (40,710 in the US) new diagnoses and 600,000 (28,920 in US) deaths worldwide, annually. Current approved treatments are limited to surgery (liver transplant, laparoscopy), radiation (brachytherapy), and a single small molecule (sorafenib). Surgery and radiation are limited to early diagnoses, leaving sorafenib as the only treatment option for advanced and metastatic cases of liver cancer. Sorafenib has a high effective dose (>1500mg/daily) and multiple undesirable side effects (cardiovascular complications, internal bleeding). Even with treatment, there is still a high degree of disease recurrence (>50%). Therefore, the field of human liver cancer has a standing order for new, effective drug candidates.
Published patent application: WO 2019/060245
OU Ref: 18001 View PDF