Ohio University

Small Molecule for the Treatment of Equine Sepsis

Overview

C10 Molecule

Sepsis is a systemic inflammatory response to an infection and is responsible for nearly one-third of all foal mortality. Current treatment consists of broad-spectrum antibiotics, IV fluids, nutritional support, and administration of other medicines as the situation demands. Survival rates vary depending on the underlying cause of the disease and range from 26-86% for septic neonatal foals, with the majority of studies showing a rate of 45-60% 1,2.

Two horses

The current invention, a small molecule that targets inflammation associated with Toll-like receptor overexpression, is able to protect horses from endotoxic shock.

Tech ID: 03007 View [PDF]

References

1The Merck Veterinary Manual. Veterinary Professionals. Management and Nutrition. Management of the Neonate. Sepsis in Foals.

2Taylor, S. (2015), A review of equine sepsis. Equine Veterinary Education, 27: 99-109.

3 US Patent 9,326,972, issued May 3, 2016.

Photo of mare and foal obtained from Google Images.