Silvana Duran Ortiz

Department of Biomedical Sciences/Edison Biotechnology Institute, Heritage College of Osteopathic Medicine

Recent News

Education

Ph.D. Molecular and Cellular Biology/Dec. 2020/ Ohio University/Athens, Ohio, USA

M.S. Food and Nutrition Sciences/Jun. 2014/ Ohio University/Athens, Ohio, USA

B.S. Biology/Dec. 2011/CES University/Medellin, Colombia

Research

I conduct aging research in Dr. John Kopchick’s laboratory to understand the role of growth hormone action in aging and age-related diseases. Specifically, I work with mouse lines that have a postnatal disruption of the growth hormone receptor and study the molecular, metabolic, and lifespan alterations in these mice.

Selected Publications

Duran-Ortiz S, List EO, Basu R, Kopchick JJ. (2021) Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age. Pituitary, Epub ahead of print. PMID: 33459974.

Young JA, Buchman M, Duran-Ortiz S, Kruse C, Bell S, Kopchick JJ, Berryman DE, List EO. (2021). Transcriptome profiling of insulin sensitive tissues from GH deficient mice following GH treatment. Pituitary, Epub ahead of print. PMID: 33433889

Qian Y, Basu R, Mathes SC, Arnett NA, Duran-Ortiz S, Funk KR, Brittain AL, Kulkarni P, Terry JC, Davis E, Singerman JT, Henry BE, List EO, Berryman DE, Kopchick JJ. (2020). Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo. Cancers (Basel), 12(12):3640. PMID: 33291663.

Duran-Ortiz S, Young JA, Jara A, Jensen EA, Basu R, List EO, Qian Y, Kopchick JJ, Berryman DE. (2020). Differential gene signature in adipose tissue depots of growth hormone transgenic mice. J Neuroendocrinol, 32(11):e12893. PMID: 33043505.

List EO, Basu R, Duran-Ortiz S, Krejsa J, Jensen EA. (2020). Mouse models of growth hormone deficiency. Rev Endocr Metab Disord, , Epub ahead of print. PMID: 33033978

List EO, Duran-Ortiz S, Kopchick JJ. (2020). Effects of tissue-specific GH receptor knockouts in mice. Mol Cell Endocrinol, 24:110919. PMID: 32592744.

List EO, Berryman DE, Basu R, Buchman M, Funk K, Kulkarni P, Duran-Ortiz S, Qian Y, Jensen EA, Young JA, Yildirim G, Yakar S, Kopchick JJ. (2020). The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH? Endocrinology, 1:161(8):bqaa097. PMID: 32556100.

Duran-Ortiz S, Noboa V, Kopchick JJ. (2020). Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update. Growth Horm IGF Res,51:1-5. PMID: 31923746.

List EO, Berryman DE, Buchman M, Jensen EA, Funk K, Duran-Ortiz S, Qian Y, Young JA, Slyby J, McKenna S, Kopchick JJ. (2019). GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity. Endocrinology, 160(7):1743-1756. PMID: 31099824.

Basu R, Kulkarni P, Qian Y, Walsh C, Arora P, Davis E, Duran-Ortiz S, Funk K, Ibarra D, Kruse C, Mathes S, McHugh T, Brittain A, Berryman DE, List EO, Okada S, Kopchick JJ. (2019). Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma. Cancers (Basel), 11(9). PMID: 31547367.

Young JA, Jensen EA, Stevens A, Duran-Ortiz S, List EO, Berryman DE, Kopchick JJ. (2019). Characterization of an intestine-specific GH receptor knockout (IntGHRKO) mouse. Growth Horm IGF Res, 46-47:5-15. PMID: 31078722.

Duran-Ortiz S, Berryman D.E, Kopchick J.J. (2019). Growth hormone impact on adipose tissue and aging. Current Opinion in Endocrine and Metabolic Research, 5 45-57.

List E.O, Berryman D.E, Buchman M,  Parker C,  Funk J,  Bell S,  Duran-Ortiz S,  Qian Y,  Young J.A, Wilson C, Slyby J, McKenna S, Jensen E.A , Kopchick J. J. (2019). Adipocyte-Specific GH Receptor-Null (AdGHRKO) Mice Have Enhanced Insulin Sensitivity With Reduced Liver Triglycerides. Endocrinology, 160: 68-80. PMID: 30462209.

Duran-Ortiz S, Bell S, Kopchick JJ. (2018). Standardizing protocols dealing with growth hormone receptor gene disruption in mice using the Cre-lox system. Growth Horm IGF Res, 43:52-57. PMID: 30195091.

Householder LA, Comisford R, Duran-Ortiz S, Lee K, Troike K, Wilson C, Jara A, Harberson M, List EO, Kopchick JJ, Berryman DE. (2018). Increased fibrosis: A novel means by which GH influences white adipose tissue function. Growth Horm IGF Res, 39:45-53. PMID: 29279183.

Duran-Ortiz S, Noboa V, Kopchick JJ. (2018). Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues. Growth Horm IGF Res, 38:3-7. PMID: 29198419.

Duran-Ortiz S, Brittain AL, Kopchick JJ. (2017). The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies. Clin Proteomics, 29;14:24. PMID: 28670222.

Junnila RK, Duran-Ortiz S, Suer O, Sustarsic EG, Berryman DE, List EO, Kopchick JJ. (2016). Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females. Endocrinology, 157(12):4502-4513. PMID: 27732088.

Jara A, Liu X, Sim D, Benner CM, Duran-Ortiz S, Qian Y, List EO, Berryman DE, Kim JK, Kopchick JJ. (2016). Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice. Endocrinology, 157(5):1929-41. PMID: 27035649.

Benencia, F., Harshman, S., Duran-Ortiz, S.*, Lubbers, E. R., List, E. O., Householder, L., Al-Naeeli M.,Liang X.,Welch L.,Kopchick JJ.,Berryman DE. (2015). Male Bovine GH Transgenic Mice Have Decreased Adiposity With an Adipose Depot-Specific Increase in Immune Cell Populations. Endocrinology, 156(5), 1794-1803.*Co-first author. PMID: 25521584.

Yang, T., Householder, L. A., Lubbers, E. R., List, E. O., Troike, K., Vesel, C., Duran-Ortiz S., Kopchick JJ., Berryman, D. E. (2015). Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet. Endocrinology, 156(2), 555-564. PMID: 25406017.