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Jixin Chen

Jixin Chen, portrait
Associate Professor
Chemistry 343, Athens Campus

Recent News


B.S., Chemistry, Nankai University, China, 1999
M.S., Chemistry, Nankai University, China, 2002
Ph.D., Chemistry, Texas A&M University, 2010
Postdoc, University of Wisconsin-Madison, 2010-2012
Postdoc, Rice University, 2012-2014


As an experimental physical chemist, the overall goal of my research is to develop and apply techniques and methods to understand the complex behavior of molecules and nanoparticles at surfaces and interfaces, leading to the development of new materials and technologies that will benefit our lives.

I have extensive experience in analytical chemistry, physical chemistry, and biochemistry. More specifically, my strengths are in the development of analytical strategies, and in understanding chemistry at surfaces and interfaces. I received my Bachelor’s and Master’s Degree from Nankai University in Tianjin, China. There, in Naijia Guan’s group, I focused on surface chemistry and kinetics for catalysis, including synthesis, characterization, and application of catalysts. During my Ph.D. studies in Paul Cremer’s and James Batteas’ groups at Texas A&M University, College Station, I was trained in biosensing. I have used plasmonics of noble metal nanostructures and fluorescence of quantum dots as platforms. After I graduated, I continued my training in Robert Hamers’ group at the University of Wisconsin, Madison for two years in surface modification of metal oxides for solar cell applications. In July 2012, I joined the Landes group at Rice University. Since then, I have been conducting research on a few bio-platforms using single-molecule super-resolution imaging and Förster resonance energy transfer (FRET).

Current Research

Development of an analytical technique for conducting super-resolution single-genome optical mapping and single-genome sensing. In many genome sequencing projects, such as the Human Genome Project, optical mapping has been used to construct ordered restriction maps for whole genomes. These maps provide scaffolds for shotgun sequence assembly and validation. Optical mapping was first developed in the 1990s by David Schwartz and his lab at New York University, and has been successfully applied in many genome sequencing projects. My research goal is to develop new optical mapping strategies with super-resolution optical nanoscopy to improve the resolution of optical mapping. Recently at Rice University, I was involved in the development of a super-resolution optical nanoscopy called motion blur point accumulation for imaging in nanoscale topography (mbPAINT), and used it to study ion-exchange chromatography for single protein separation and DNA imaging. I will continue working in the optical mapping project, and start to explore a variety of single-molecule areas, such as molecular tracking and single-molecule FRET. In addition, I will continue to work on the surface modifications of a few materials (e.g. metal, metal oxides, semiconductor, and glass), and molecular interfacial dynamics for applications such as catalysis, separation, biosensing, anticorrosion coating, and biosensing.

Selected Publications

Ming-Ho Liu, Tzu-Chun Chen, Juvinch R Vicente, Chun-Nien Yao, Yu-Chi Yang, Chuan-Pin Chen, Pin-Wen Lin, Yu-Chieh Ho, Jixin Chen, Shu-Yi Lin, Yang-Hsiang Chan, Cyanine-Based Polymer Dots with Long-Wavelength Excitation and Near-Infrared Fluorescence beyond 900 nm for In Vivo Biological Imaging. ACS Appl. Bio Mater. 2020, 3, 6, 3846–3858.

Juvinch R Vicente, Jixin Chen*, Phase Segregation and Photothermal Remixing of Mixed-Halide Lead Perovskites. J. Phys. Chem. Lett. 2020, 11, 5, 1802–1807.

Kristina Shrestha, Juvinch R Vicente, Ali Rafiei Miandashti, Jixin Chen, Hugh H Richardson, Time-resolved temperature-jump measurements and steady-state thermal imaging of nanoscale heat transfer of gold nanostructures on AlGaN:Er3+ thin films. J. Chem. Phys. 152, 034706 (2020). 

Kurt Waldo E. Sy Piecco, Juvinch R. Vicente, Joseph R. Pyle, David C. Ingram, Martin E. Kordesch, Jixin Chen*, Reusable Chemically-Micropatterned Substrates via Sequential Photoinitiated Thiol-Ene Reactions as Template for Perovskite Thin-Film Microarrays. ACS Appl. Electron. Mater. 2019, DOI: 10.1021/acsaelm.9b00457.

Joseph R. Pyle, Kurt Waldo E. Sy Piecco, Juvinch R. Vicente, Jixin Chen*, In-situ Sensing of Reactive Oxygen Species on Dye-Stained Single DNA Molecules under Illumination. Langmuir, 2019, 35, 35, 11308-11314.

William Lum, Dinesh Gautam, Jixin Chen, Laura B. Sagle, Single Molecule Protein Patterning Using Hole Mask Colloidal Lithography. Nanoscale, 2019, 11,16228-16234.

Juvinch R. Vicente, Ali Rafiei Miandashti, Kurt Sy Piecco, Joseph R. Pyle, Martin E. Kordesch, Jixin Chen*, Single-Particle Organolead Halide Perovskite Photoluminescence as a Probe for Surface Reaction Kinetics. ACS Applied Matierals & Interfaces, 2019, 11(19), 18034-18043.

Kurt W. Sy Piecco, Ahmed M. Aboelenen, Joseph R. Pyle, Juvinch R. Vicente, Dinesh Gautam, Jixin Chen*, A Kinetic Model under Light-limited Condition for Photo-Initiatied Thiol-Ene Coupling Reactions. ACS Omega, 2018, 3(10), 14327-14332.

Jeeranan Nonkumwong, Kurt W. Sy Piecco, Uvinduni I. Premadasa, Ahmed M. Adoelenen, Andrew Tangonan, Jixin Chen, Laongnuan Srisombat, Katherine, L. A. Cimatu, Successive Surface Reactions on Hydrophilic Quartz for Modified Magnetic Nanoparticle Attachment Probed by Sum Frequency Generation Spectroscopy. Langmuir, 2018, 34(43), 12680-12693.

Wei-Kai TSai, Chun-I Wang, Chia-Hsien Liao, Tsai-Jhen Kuo, Ming-Ho Liu, Cho-Ping Hsu, Shu-Yi Lin, Chang-Yi Wu, Joseph R. Pyle, Jixin Chen, Yang-Hsiang Chan. Molecular Design of Near-Infrared Fluorescent Pdots for Tumor Targeting: AggregationInduced Emission versus Anti-Aggregation-Caused Quenching. Chemical Science, 2019, 10, 198-207.

Lei Wang, Joseph R. Pyle, Katherine L. A. Cimatu, Jixin Chen,* Ultrafast transient absorption spectra of photoexcited YOYO-1 molecules call for additional investigations of their fluorescence quenching mechanism. J. Photochem. Photobiol. A: Chem., 2018, 367, 411-419.

Gregory J. Deye, Juvinch R. Vicente, Jixin Chen, Jacob W. Ciszek, The Influence of Defects on the Reactivity of Organic Surfaces. J. Phys. Chem. C. 2018, 122(27), 15582-15587.

Juvinch R. Vicente, Jixin Chen,* Perovskite Solar Cells. Encyclopedia of Chemical Processing. 2018, In press.

Joseph R. Pyle, Kurt W.E. Sy Piecco, Juvinch R. Vicente, Jixin Chen,* Optical Genome Mapping. Encyclopedia of Chemical Processing. 2018, In Press.

Joseph R. Pyle, Jixin Chen,* Photobleaching of YOYO-1 in Super-Resolution Single-DNA Fluorescence Imaging. BJNano. 2017, 8, 2296-2306.

Gregory Deye, Juvinch R. Vicente, Shawn M. Dalke, Selma Piranej, Jixin Chen, Jacob W. Ciszek, The Role of Thermal Activation and Molecular Structure on the Reaction of Molecular Surfaces. Langmuir 2017, 33(33), 8140-8146

Chi-Shiang Ke, Chia-Chia Fang, Jia-Ying Yan, Po-Jung Tseng, Joseph R. Pyle, Chuan-Pin Chen, Shu-Yi Lin, Jixin Chen, Xuanjun Zhang, Yang-Hsiang Chan, Molecular Engineering and Design of Semiconducting Polymer Dots with Narrow-Band, Near-Infrared Emission for in Vivo Biological Imaging. ACS Nano 2017, 11(3), 3166-3177

Jixin Chen,* Joseph R Pyle, Kurt Waldo Sy Piecco, Anatoly B Kolomeisky, Christy F Landes, A Two-Step Method for smFRET Data Analysis. J. Phys. Chem. B 2016, 120(29), 7128 - 7132 (SI with MATLAB codes included) (*corresponding author. Work is selected in the Virtual Issue of JPC B on Biophysics.)

Selma Piranej, David A. Turner, Shawn M. Dalke, Haejun Park, Brittni A. Qualizza, Juvinch Vicente, Jixin Chen, Jacob W. Ciszek. Tunable Interfaces on Tetracene and Pentacene Thin-Films via Monolayers. CrystEngComm 2016, 18, 6062-6068

Kisley, L.; Chen, J. X.; Mansur, A. P.; Shuang, B.; Kourentzi, K.; Poongavanam, M.-V.; Chen, W.-H.; Dhamane, S.; Willson, R. C.; Landes, C. F., Unified super-resolution experiments and stochastic theory provide mechanistic insight into protein ion-exchange adsorptive separations. PNAS, 2014, doi: 10.1073/pnas.1318405111 (Reported by NSF Science360, Rice News, Physics News, Phys.org, and etc.)

Shuang, B.; Chen, J. X.; Kisley, L.; Landes, C. F., Troika of single particle tracking programing: SNR enhancement, particle identification, and mapping. Physical Chemistry Chemical Physics, 2013, 16, 624-634.

Chen, J. X.; Bremauntz, A.; Kisley, L.; Shuang, B.; Landes, C. F., Super-Resolution mbPAINT for Optical Localization of Single-Stranded DNA. ACS Applied Materials & Interface, 2013, 5, 9338−9343. (Reported by Rice News, Science Daily, and Novus Light…)

Chen, J.X.; Ruther, R.; Tan, Y.; Bishop, L.; Hamers. R. J., Molecules on ZnO surfaces: Molecular Adsorption on ZnO(10-10) Single Crystal Surfaces: Morphology and Charge Transfer. Langmuir 2012, 28, 10437-10455.

Chen, J. X.; Franking, R.; Ruther, R. E.; Tan, Y. Z.; He, X. Y.; Hogendoorn, S. R.; Hamers, R. J., Formation of Molecular Monolayers on TiO2 Surfaces: A Surface Analogue of the Williamson Ether Synthesis. Langmuir 2011, 27, 6879-6889.

Chan, Y. H.; Chen, J. X.; Liu, Q. S.; Wark, S. E.; Son, D. H.; Batteas, J. D., Ultrasensitive Copper(II) Detection Using Plasmon-Enhanced and Photo-Brightened Luminescence of CdSe Quantum Dots. Analytical chemistry 2010, 82, 3671-3678.

Chen, J. X.; Chan, Y. H.; Yang, T. L.; Wark, S. E.; Son, D. H.; Batteas, J. D., Spatially Selective Optical Tuning of Quantum Dot Thin Film Luminescence. Journal of the American Chemical Society 2009, 131, 18204-18205. (Highlighted in JACS Select, an online collection showcasing significant recent publications in JACS; and Photonics Spectra news, an industrial magazine)

Chen, J. X.; Liao, W. S.; Chen, X.; Yang, T. L.; Wark, S. E.; Son, D. H.; Batteas, J. D.; Cremer, P. S., Evaporation-Induced Assembly of Quantum Dots into Nanorings. ACS Nano 2009, 3, 173-180.

Chen, J. X. (co-first author); Chan, Y. H. (co-first author); Wark, S. E.; Skiles, S. L.; Son, D. H.; Batteas, J. D., Using Patterned Arrays of Metal Nanoparticles to Probe Plasmon Enhanced Luminescence of CdSe Quantum Dots. ACS Nano 2009, 3, 1735-1744.

Shi, J. J.; Chen, J. X.; Cremer, P. S., Sub-100 nm Patterning of Supported Bilayers by Nanoshaving Lithography. Journal of the American Chemical Society 2008, 130, 2718-2719.

Liao, W. S.; Chen, X.; Chen, J. X.; Cremer, P. S., Templating Water Stains for Nanolithography. Nano Letters 2007, 7, 2452-2458.

Zhang, F. X.; Jin, R. C.; Chen, J. X.; Shao, C. Z.; Gao, W. L.; Li, L. D.; Guan, N. J., High Photocatalytic Activity and Selectivity for Nitrogen in Nitrate Reduction on Ag/TiO2 Catalyst with Fine Silver Clusters. Journal of Catalysis 2005, 232, 424-431.

Li, L. D.; Chen, J. X.; Zhang, S. J.; Zhang, F. X.; Guan, N. J.; Wang, T. Y.; Liu, S. L., Selective Catalytic Reduction of Nitrogen Oxides from Exhaust of Lean Burn Engine over in situ Synthesized Cu-ZSM-5/Cordierite. Environmental Science & Technology 2005, 39, 2841-2847.

Gao, W. L.; Guan, N. J.; Chen, J. X.; Guan, X. X.; Jin, R. C.; Zeng, H. S.; Liu, Z. G.; Zhang, F. X., Titania Supported Pd-Cu Bimetallic Catalyst for the Reduction of Nitrate in Drinking Water. Applied Catalysis B: Environmental 2003, 46, 341-351.