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Tingyue Gu

Professor, Chemical and Biomolecular Engineering
Chemical and Biomolecular Engineering, Biomedical Engineering, Institute for Corrosion and Multiphase Technology
STKR 167B
gu@ohio.edu
Phone: 740.593.1499

http://www.ohio.edu/people/gu

Before joining the Ohio University faculty in 1992, Dr. Gu worked in the Biotechnology Group in the Corporate Research Department of Miller Brewing Company. He was involved in development of a pilot-scale process for production of a rare and naturally occurring recombinant protein.

Dr. Gu is internationally known for his work on chromatography modeling and scale-up. He is the author of a chromatography simulation package called "Chromulator" that has been used by many dozens of university researchers in over thirty countries, and several major pharmaceutical and biotech companies.

Dr. Gu has carried out research in protein purification, fungal and bacterial fermentation. In recently years, he started research in microbiologically influenced corrosion (MIC) in the oil and gas industry. He is specifically interested in MIC mechanism, biofilm ecology, MIC in underdeposit pitting attacks involving sand, biocide dosing and degradation modeling, reservoir souring modeling, and modeling and prediction of MIC in pipelines. He is a consultant for the oil and gas industry for MIC problems. He is an Executive Editor of Journal of Microbial & Biochemical Technology. He is an editorial board member of Bioprocess & Biosystems Engineering and journal of Chemistry. His latest inventions include a new type of online biofilm sensor, a drop-in disposable MIC-e-cell biofilm/MIC sensor and a new green biocide cocktail containing a naturally occurring quorum-quenching chemical against tough biofilms. The cocktail is environmentally friendly for applications in oil and gas pipelines and in hydraulic fracturing ("fracking") fluids.

Research Details: Dr. Gu is interested in the following research areas: Microbiologically influenced corrosion, microbial fuel cells, biofilm treatment, cellulosic biomass utilization, fermentation, and bioseparations (including chromatography scale-up and media development).
Research Topics
Chemical and Biomolecular Engineering
Microbiologically Influenced Corrosion
Biofilm mitigation
Microbial fuel cells
Bioelectrochemistry
Fermentation and bioseparations

Dr. Gu is also interested in cellulosic biomass utilization and microbial fuel cells for waste treatment. He models bio-electrochemical processes in biofilms and mass transfer in porous media with and without reactions. He develops software on the Windows platform for academic and industrial applications.


Research Interests: Microbiologically Influenced Corrosion, Biofilm Mitigation, Microbial Fuel Cells, Bioelectrochemistry,

All Degrees Earned: Ph.D., Chemical Engineering, Purdue University, August 1990 BS, Chemical Engineering, Zhejiang University, May 1985

Book, Chapter in Scholarly Book-Revised (1)

  • Gu, T. Radial flow chromatography in Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology. New York: Wiley; 1630-1641.

Journal Article, Academic Journal (41)

  • Zhang, P., Xu, D., Li, Y., Yang, K., Gu, T. Electron Mediators Accelerate the Microbiologically Influenced Corrosion of 304 Stainless Steel. Bioelectrochemistry; 101: 14–21.
  • Nan, L., Xu, D., Gu, T., Song, X., Yang, K. Microbiological influenced corrosion resistance characteristics of a 304L-Cu stainless steel against Escherichia coli. Materials Science & Engineering C: Materials for biological applications; 48: 228-234.
  • Xia, J., Yang, C., Xu, D., Sun, D., Nan, L., Sun, Z., Li, Q., Gu, T., Yang, K. Laboratory Investigation of Microbiologically Influenced Corrosion (MIC) Resistance of a Novel Cu-bearing 2205 Duplex Stainless Steel in the Presence of an Aerobic Marine Pseudomonas aeruginosa Biofilm. Biofouling; 31: 481-492.
  • Mehay, A., Gu, T. A General Rate Model of Ion-Exchange Chromatography for Investigating Ion-Exchange Behavior and Scale-up. Journal of Microbial & Biochemical Technology.
  • Xu, D., Li, Y., Gu, T. D-methionine as a biofilm dispersal signaling molecule enhanced tetrakis hydroxymethyl phosphonium sulfate mitigation of Desulfovibrio vulgaris biofilm and biocorrosion pitting. New York: Materials and Corrosion, Wiley; 65: 837–845 . http://onlinelibrary.wiley.com/doi/10.1002/maco.201206894/full.
  • Gu, T. Theoretical Modeling of The Possibility of Acid Producing Bacteria Causing Fast Pitting Biocorrosion . Los Angeles, CA: Journal of Microbial & Biochemical Technology; 6: 67-73.
  • Gu, T. Carbon Source Starvation Triggered More Aggressive Corrosion Against Carbon Steel by the Desulfovibrio vulgaris Biofilm. International Biodeterioration & Biodegradation.
  • Zheng , B., Li, K., Liu, H., Gu, T. Effects of Magnetic Fields on Microbiologically Influenced Corrosion. Industrial & Engineering Chemistry Research.
  • Luo, J., Ma, G., Zhou, W., Su, Z., Gu, T. Comparison of Fully-Porous Beads and Cored Beads in Size Exclusion Chromatography for Protein Purification . Chemical Engineering Science; 102: 99-105. http://www.sciencedirect.com/science/article/pii/S000925091300537X.
  • Chi, M., He, H., Wang, H., Zhou, M., Gu, T. Graphite Felt Anode Modified by Electropolymerization of Nano-Polypyrrole to Improve Microbial Fuel Cell (MFC) Production of Bioelectricity. Journal of Microbial & Biochemical Technology; S12-004: 1-4.
  • Xu, D., Huang, W., Ruschau, G., Hornemann, J., Wen, J., Gu, T. Laboratory Investigation of MIC Threat Due to Hydrotest Using Untreated Seawater and Subsequent Exposure to Pipeline Fluids with and without SRB Spiking. Elsevier: Engineering Failure Analysis; 28: 149-159.
  • Xu, D., Li, Y., Song, F., Gu, T. Laboratory Investigation of Microbiologically Influenced Corrosion of C1018 Carbon Steel by Nitrate Reducing Bacterium Bacillus licheniformis. Corrosin Science; 77: 385–390.
  • Zhou, M., Yang, J., Wang, H., Jin, T., Xu, D., Gu, T. Microbial Fuel Cells (MFCs) and Microbial Electrolysis Cells (MECs) for the Production of Bioelectricity and Biomaterials. M. Zhou, J Yang, H. Wang, T. Jin, D. Xu, : Environmental Technology; 34: 1915-1928.
  • Gu, T., Iyer, G., Cheng, . Parameter Estimation And Rate Model Simulation Of Partial Breakthrough Of Bovine Serum Albumin On A Column Packed With Large Q Sepharose Anion-Exchange Particles. . Separation and Purification Technology; 116: 319-326.
  • Gu, T., Held, M., Faik, A., , . Supercritical CO2 and Ionic Liquids for the Pretreatment of Lignocellulosic Biomass in Bioethanol Production. 34. Environmental Technology; 1735-1749.
  • Zhou, M., Gu, T. The Next Breakthrough in Microbial Fuel Cells and Microbial Electrolysis Cells for Bioenergy and Bioproducts. Journal of Microbial & Biochemical Technology; S12-003: 1-4.
  • Wen, J., Xu, D., Gu, T., Raad, I. A green triple biocide cocktail consisting of a biocide, EDDS and methanol for the mitigation of planktonic and sessile SRB. World Journal of Microbiology and Biotechnology; 28: 431-435.
  • Xu, D., Li, Y., Gu, T. A synergistic D-tyrosine and tetrakis hydroxymethyl phosphonium sulfate biocide combination for the mitigation of an SRB biofilm. World Journal of Microbiology and Biotechnology; 28: 3067-3074.
  • Xu, D., Wen, J., Gu, T., Raad, I. Biocide Cocktail Consisting of Glutaraldehyde, Ethylene Diamine Disuccinate (EDDS), and Methanol for the Mitigation of Souring and Biocorrosion. Corrosion; 68: 994-1002.
  • Xu, D., Wen, J., Fu, W., Gu, T., Raad, I., , . D-amino acids for the enhancement of a binary biocide cocktail consisting of THPS and EDDS against an SRB biofilm. World Journal of Microbiology and Biotechnology; 28: 1641-1646.
  • Wang, J., Gu, T., Zhong, J., , . Enhanced Recovery of Antitumor Ganoderic Acid T from Ganoderma lucidum Mycelia by Novel Chemical Conversion Strategy . Biotechnology and Bioengineering; 109: 754–762.
  • Gu, T. New Understandings of Biocorrosion Mechanisms and their Classifications. Journal of Microbial & Biochemical Technology; 4: 3-6. http://www.omicsonline.org/1948-5948/JMBT-04-e107.digital/JMBT-04-e107.html.
  • Zhou, M., Wang, H., Hassett, D., Gu, T. Recent Advances in Microbial Fuel Cells (MFCs) and Microbial Electrolysis Cells (MECs) For Wastewater Treatment, Bioenergy and Bioproducts. Journal of Chemical Technology & Biotechnology, Wiley; 88: 508-518.
  • Gu, T., Liu, M., Cheng, K., Ramaswamy, S., Wang, C., , . A General Rate Model Approach for the Optimization of the Core Radius Fraction for Multicomponent Elution in Preparative Nonlinear Liquid Chromatography Using Cored Beads. Chemical Engineering Science; 66: 3531–3539.
  • Narayanaswamy, N., Faik, A., Goetz, D., Gu, T., , . Supercritical Carbon Dioxide Pretreatment of Corn Stover and Switchgrass for Lignocellulosic Ethanol Production. Bioresource Technology ; 102: 6995-7000.
  • Gu, T. Chelators enhanced biocide inhibition of planktonic sulfate-reducing bacterial growth. World Journal of Microbiology and Biotechnology; 26: 1053-1057.
  • Gu, T. Enhanced Biosynthetic Gene Expressions and Production of Ganoderic Acids in Static Liquid Culture of Ganoderma lucidum under Phenobarbital Induction. Applied Microbiology and Biotechnology; 86: 1367–1374.
  • Wang, L., Ridgway, D., Gu, T., Moo-Young, M. Kinetic Modeling of Cell Growth and Product Formation in Submerged Culture of Recombinant Aspergillus niger. Chemical Engineering Communications; 196: 481-490.
  • Zhao, K., Wen, J., Gu, T., Kopliku, A., Cruz, I. Mechanistic Modeling of Anaerobic THPS Degradation Under Alkaline Condition in the Presence of Mild Steel. July. Materials Performances; 62-66.
  • Du, Z., Li, H., Gu, T. A state of the art review on microbial fuel cells: A promising technology for wastewater treatment and bioenergy. Biotechnology Advances; 25: 464-482.
  • Gu, T., Zhang, L. Partition Coefficients of Some Antibiotics, Peptides and Amino Acids in Liquid-Liquid Partitioning of the Acetonitrile-Water System At Subzero Temperatures. Chemical Engineering Communications; 194: 828-834.
  • Zhou, W., Gu, T., Su, Z., Ma, G. Synthesis of macroporous poly(glycidyl methacrylate) microspheres by surfactant reverse micelles swelling method. European Polymer Journa; 43: 4493-4502.
  • Zhou, W., Gu, T., Su, Z., Ma, G. Synthesis of macroporous poly(styrene-divinyl benzene) microspheres by surfactant reverse micelles swelling method. Polymer; 48: 1981-1988.
  • Tan, W., Gu, T., Zhong, J. Separation of Targeted Ganoderic Acids from Ganoderma lucidum by Reversed Phase Liquid Chromatography with Ultraviolet and Mass Spectrometry Detections. Biochemical Engineering Journal; 32: 205-210.
  • Gu, T., Tsai, G., Tsao, G. Synthesis of Rigid Cyclodextrin-Containing Polymeric Resins for Adsorption. Journal of Inclusion Phenomena and Macrocyclic Chemistry; 56: 375-379.
  • Wang, L., Ridgway, D., Gu, T., Moo-Young, M. Bioprocess Strategies to Improve Heterologous Protein Production in Filamentous Fungi. Biotechnology Advances; 23: 115-129.
  • Huang, H., Gu, T., Moo-Young, M. Data Acquisition and Control of A 22-L B. Braun Fermenter Using LabVIEW. Chemical Engineering Communications; 192: 137-144.
  • Xu, J., Shpak, E., Gu, T., Moo-Young, M., Kieliszewski, M. Production of Recombinant Plant Gum With Tobacco Cell Culture in Bioreactor and Gum Characterization. Biotech. & Bioeng; 90: 578-588.
  • Gu, T., Zhou, W., Ma, G., Su, Z. Rigid gigaporous chromatographic media and their potential impact on downstream processing. China Particuology; 3: 349-353.
  • Huang, H., Ridgway, D., Gu, T., Moo-Young, M. Enhanced Amylase Production By Bacillus subtilis Using A Dual Exponential Feeding Strategy. Bioprocess and Biosystems Engineering; 27: 63-69.
  • Gu, T., Syu, M. Modeling of Immobilized Cell Columns for Bioconversion and Wastewater Treatment. Biotechnology Progress; 30: 1460-1466.

Book, Chapter in Scholarly Book (10)

  • Gu, T., Xu, D., Zhang, P., Li, Y., Lindenberger, A. Microbiologically Influenced Corrosion and Its Impact on Metals and Other Materia. Boca Raton, Florida: CRC Press.
  • Held, M., Jiang, N., Basu, D., Showalter, A., Faik, A. Plant Cell Wall Polysaccharides: Structure and Biosynthesis. Springer.
  • Zhou, M., Yang, J., Wang, H., Jin, T., Hassett, D., Gu, T. Bio-electrochemistry of microbial fuel cells and their potential applications in bioenergy. Elsevier.
  • Luo, J., Cai, M., Gu, T. Pretreatment of Lignocellulosic Biomass Using Green Ionic Liquids . Berlin-New York: Springer.
  • Gu, T. Pretreatment of Lignocellulosic Biomass Using Supercritical Carbon Dioxide As A Green Solvent. Berlin-New York: Springer.
  • Tong, M., Du, Z., Gu, T., , . Converting low-grade biomass to produce energy using bio-fuel cells,Chapter 4 in Eco- and Renewable Energy Materials . Hauppauge, NY: Nova Publishers; 73-97.
  • Zhou, M., Jin, T., Wu, Z., Chi, M., Gu, T. Microbial Fuel Cells for Bioenergy and Bioproducts, Chapter 8 in Bioenergy and Bioproducts edited by K. Gopalakrishnan, J. van Leeuwen, R. Brown. New York: Bioenergy and Bioproducts, Springer-Verlag; 131-172.
  • Guo, K., Hassett, D., Gu, T. Microbial Fuel Cells: Electricity Generation from Organic Wastes by Microbes, Chapter 9 in Microbial Biotechnology: Energy and Environment . Oxon: CAB International; 162-189.
  • Huang, L., Cheng, S., Hassett, D., Gu, T. Wastewater treatment with concomitant bioenergy production using microbial fuel cells, Chapter 14 in: Water Treatment And Pollution Prevention: Advances In Research edited by S. K. Sharma and R. Sanghi. Berlin-New York: Springer Verlag; 405-452.
  • Gu, T. Selection of Biochemical Separation Processes. 8. McGraw-Hill, New York: Perry’s Handbook of Engineering; 20-71 to 20-85.

Book, Scholarly (1)

Book, Scholarly-Revised (1)

  • Gu, T. Mathematical Modeling and Scale-Up of Liquid Chromatography, 2nd Edition with Application Examples. Springer; 200+ pages.

Conference Proceeding (7)

  • Gu, T. Can Acid Producing Bacteria Be Responsible for Very Fast MIC Pitting? . Houston, TX: Corrosion/2012; Paper No. C2012-0001214.
  • Xu, D., Gu, T. Bioenergetics Explains When and Why More Severe MIC Pitting by SRB Can Occur. Houston,, TX: CORROSION/2012; Paper No. 11426.
  • Gu, T., Xu, D., , . Demystifying MIC Mechanisms. Houston, TX: CORROSION/2009; Paper No. 10213.
  • Zhao, k., Gu, T., Cruz, I., Kopliku, A., , . Laboratory Investigation Of MIC In Hydrotesting Using Seawater. Houston, TX: CORROSION/2010; Paper No. 10406.
  • Gu, T., Zhao, K., Nesic, S., , . A Practical Mechanistic Model for MIC Based on a Biocatalytic Cathodic Sulfate Reduction (BCSR) Theory. CORROSION/2009; Paper No. 09390.
  • Zhao, K., Wen, J., Gu, T., Kopliku, A., Cruz, I. Mechanistic Modeling of Anaerobic THPS Degradation In Seawater Under Various Conditions. Houston, TX: CORROSION/2008; Paper No. 08512.
  • Wen, J., Gu, T., Nesic, S. Investigation of The Effects of Fluid Flow On SRB Biofilm. Houston, TX: CORROSION/2007; Paper No. 07516.

Journal Article, Professional Journal (2)

  • Fu, W., Li, Y., Xu, D., Gu, T. Comparing two different types of anaerobic copper biocorrosion by sulfate- and nitrate-reducing bacteria. Materials Performance, June; 66-70.
  • Zhao, K., Gu, T., Cruz, I., Kopliku, A. Laboratory Investigation of Microbiologically Influenced Corrosion In Pipeline Hydrotest Using Seawater. Houston, TX: Materials Performances; 52: 64-69.

Patents

  • Gu, T., , D. COMPOSITIONS AND METHODS FOR TREATING BIOFILMS. US 9,034,812 B2.
  • Gu, T. Methods and Compositions for Applications Related to Microbiologically Influenced Corrosion. GB2492687.
  • Gu, T., , . Methods and Compositions for Applications Related to Microbiologically Influenced Corrosion.
  • Gu, T. METHODS AND COMPOSITIONS FOR DETECTION OF BIOFILMS.