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Kelly McCall

Kelly McCall
Professor, Endocrinology, Specialty Medicine
ARC 302B
Biomedical Engineering

Research Interests: Diabetes, Autoimmune Disease, Tumor Biology, Innate Immunity

Journal Article, Academic Journal (34)

  • McCall, K., Walter, D., Patton, A., Thuma, J., Courreges de Benencia, M., Palczewski, G., Goetz, D., Bergmeier, S., Schwartz, F. (2023). Anti-Inflammatory and Therapeutic Effects of a Novel Small-Molecule Inhibitor of Inflammation in a Male C57BL/6J Mouse Model of Obesity-Induced NAFLD/MAFLD. 16. Journal of Inflammation Research; 2023: 5339-5366.
  • Ghazanfari, D., Courreges de Benencia, M., Belinski, L., Lloyd, J., Bergmeier, S., McCall, K., Goetz, D. (2022). Mechanistic Insights into SARS-CoV-2 Spike Protein Induction of the Chemokine CXCL10. Submitted.
  • Benner, S., Walter, D., Thuma, J., Courreges, M., James, C., Schwartz, F., McCall, K. (2022). TLR3 is Critical to the Pancreatic Islet Minieu Required for CVB4-Induced Type 1 Diabetes in Female NOD Mice. Pancreas.
  • Ghazanfari, D., Courreges, M., Belinski, L., Bergmeier, S., McCall, K., Goetz, D. (2022). Evidence for investigating GSK-3 inhibitors as potential therapeutics for severe COVID-19. Biochemical and Biophysical Research Communications; 605: 171-176.
  • Walter, D., Thuma, J., Malgor, R., Schwartz, F., McCall, K., Coschigano, K. (2021). Consequences of Both Coxsackievirus B4 and Type 1 Diabetes on Female Non-Obese Diabetic Mouse Kidneys.. 11. Microorganisms; 9.
  • Ghazanfari, D., Noori, M., Bergmeier, S., Hines, J., McCall, K., Goetz, D. (2021). A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism.. Bioorganic & medicinal chemistry; 40: 116179.
  • Kauffman, M., Allen, A., Reynolds, N., Ghazanfari, D., Nazemidashtarjandi, S., Faik, A., Burdick, M., McCall, K., Goetz, D. (2020). Evidence that Knock Down of GSK-3b in Haploid Chronic Myelogenous Leukemia Cells Augments IFN-g Induced Apoptosis and Necrosis. Leukemia Research.
  • Kauffman, M., Nazemidashtarjandi, S., Ghazanfari, D., Allen, A., Reynolds, N., Faik, A., Burdick, M., McCall, K., Goetz, D. (2020). Evidence that knock down of GSK-3β in Chronic Myelogenous Leukemia cells augments IFN-γ-induced apoptosis.. Leukemia Research; 99: 106464.
  • Noori, M., Courreges, M., Bergmeier, S., McCall, K., Goetz, D. (2020). Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor.. European Journal of Pharmacology; 883: 173340.
  • Walter, D., Benner, S., Oaks, R., Thuma, J., Malgor, R., Schwartz, F., Coschigano, K., McCall, K. (2020). Coxsackievirus B4 Exposure Results in Variable Pattern Recognition Response in the Kidneys of Female Non-obese Diabetic Mice Before Establishment of Diabetes.. Viral immunology.
  • McCall, K., Muccioli, M., Benencia, F. (2020). Toll-Like Receptors Signaling in the Tumor Microenvironment.. Advances in experimental medicine and biology; 1223: 81-97.
  • Noori, M., Bhatt, P., Courreges, M., Ghazanfari, D., Cuckler, C., Orac, C., McMills, M., Schwartz, F., Deosarkar, S., Bergmeier, S., McCall, K., Goetz, D. (2019). Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3. Am J Physiol - Cell Physiol; 317: C1289-C1303.
  • Muccioli, M., Nandigam, H., Loftus, T., Singh, M., Venkatesh, A., Wright, J., Pate, M., McCall, K., Benencia, F. (2018). Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues.. 94. Oncotarget; 9: 36666-36683.
  • Patton, A., Church, T., Wilson, C., Thuma, J., Goetz, D., Berryman, D., List, E., Schwartz, F., McCall, K. (2018). Phenylmethimazole abrogates diet-induced inflammation, glucose intolerance and NAFLD.. 3. The Journal of endocrinology; 237: 337-351.
  • Noori, M., O'Brien, J., Champa, Z., Deosarkar, S., Lanier, O., Qi, C., Burdick, M., Schwartz, F., Bergmeier, S., McCall, K., Goetz, D. (2017). Phenylmethimazole and a Thiazole Derivative of Phenylmethimazole Inhibit IL-6 Expression by Triple Negative Breast Cancer Cells. European Journal of Pharmacology; 803: 130-137.
  • Schwartz, A., Dickerson, E., Dagia, N., Malgor, R., McCall, K. (2016). TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration.. 69. Oncotarget; 8: 113295-113302.
  • Szulawski, R., Nakazawa, M., McCall, K., James, C., Schwartz, F. (2016). Laser capture microdissection tailored to type 1 diabetes mellitus research.. 6. BioTechniques; 60: 293-8.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple Modifications to Methimazole that Enhance its Inhibitory Effect on Tumor Necrosis Factor-alpha-Induced Vascular Cell Adhesion Molecule-1 Expression by Human Endothelial Cells. European Journal of Pharmacology; 751: 59-66.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple modifications to methimazole that enhance its inhibitory effect on tumor necrosis factor-α-induced vascular cell adhesion molecule-1 expression by human endothelial cells.. European journal of pharmacology; 751: 59-66.
  • McCall, K., Thuma, J., Courreges, M., Benencia, F., James, C., Malgor, R., Kantake, N., Mudd, W., Denlinger, N., Nolan, B., Wen, L., Schwartz, F. (2015). Toll-like receptor 3 is critical for coxsackievirus B4-induced type 1 diabetes in female NOD mice.. 2. Endocrinology; 156: 453-61.
  • Guo, A., Daniels, N., Thuma, J., McCall, K., Malgor, R., Schwartz, F. (2015). Diet is critical for prolonged glycemic control after short-term insulin treatment in high-fat diet-induced type 2 diabetic male mice.. 1. PloS one; 10: e0117556.
  • Deosarkar, S., Bhatt, P., Gillespie, J., Goetz, D., McCall, K. (2014). Inhibition of LPS-induced TLR4 signaling products in murine macrophages by phenylmethimazole: an assay methodology for screening potential phenylmethimazole analogs.. 8. Drug development research; 75: 497-509.
  • Malgor, R., Bhatt, P., Connolly, B., Jacoby, D., Feldmann, K., Silver, M., Nakazawa, M., McCall, K., Goetz, D. (2014). Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions.. 4. Inflammation research : official journal of the European Histamine Research Society ... [et al.]; 63: 277-85.
  • Slyvka, Y., Nowak, F., Wooten, M., McCall, K., Malgor, R., Wood, A., Inman, S. (2013). Urate Transporter 1 Protein Levels and Localization in Type 2 Diabetic and Non-Diabetic Zucker Rat Kidneys. 1. 3: 63-68.
  • McCall, K., Schmerr, M., Thuma, J., James, C., Courreges, M., Benencia, F., Malgor, R., Schwartz, F. (2013). Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice.. 4. Molecules (Basel, Switzerland); 18: 3841-58.
  • Courreges, M., Kantake, N., Goetz, D., Schwartz, F., McCall, K. (2012). Phenylmethimazole blocks dsRNA-induced IRF3 nuclear translocation and homodimerization.. 10. Molecules (Basel, Switzerland); 17: 12365-77.
  • Benavides, U., Gonzalez-Murguiondo, M., Harii, N., Lewis, C., Schwartz, A., Giuliani, C., Napolitano, G., Dagia, N., Malgor, R., McCall, K., Kohn, L. (2012). Phenylmethimazole inhibits production of proinflammatory mediators and is protective in an experimental model of endotoxic shock*.. 3. Critical care medicine; 40: 886-94.
  • Bhatt, P., Lewis, C., House, D., Keller, C., Kohn, L., Silver, M., McCall, K., Goetz, D., Malgor, R. (2012). Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions, and Oxidized LDL Treated Human Monocyte-Derived Macrophages.. The open circulation & vascular journal; 5: 1-7.
  • McCall, K., Holliday, D., Dickerson, E., Wallace, B., Schwartz, A., Schwartz, C., Lewis, C., Kohn, L., Schwartz, F. (2010). Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages.. 3. The Journal of endocrinology; 207: 343-53.
  • Kummitha, C., Mayle, K., Christman, 2nd, M., Deosarkar, S., Schwartz, A., McCall, K., Kohn, L., Malgor, R., Goetz, D. (2010). A sandwich ELISA for the detection of Wnt5a.. 1-2. Journal of immunological methods; 352: 38-44.
  • Schwartz, A., Malgor, R., Dickerson, E., Weeraratna, A., Slominski, A., Wortsman, J., Harii, N., Kohn, A., Moon, R., Schwartz, F., Goetz, D., Kohn, L., McCall, K. (2009). Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration.. 12. Clinical cancer research : an official journal of the American Association for Cancer Research; 15: 4114-22.
  • Christman, 2nd, M., Goetz, D., Dickerson, E., McCall, K., Lewis, C., Benencia, F., Silver, M., Kohn, L., Malgor, R. (2008). Wnt5a is expressed in murine and human atherosclerotic lesions.. 6. American journal of physiology. Heart and circulatory physiology; 294: H2864-70.
  • McCall, K., Harii, N., Lewis, C., Malgor, R., Kim, W., Saji, M., Kohn, A., Moon, R., Kohn, L. (2007). High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration.. 9. Endocrinology; 148: 4226-37.
  • Kim, W., Lewis, C., McCall, K., Malgor, R., Kohn, A., Moon, R., Kohn, L. (2007). Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms.. 1. The Journal of endocrinology; 193: 93-106.

Book, Chapter in Scholarly Book (1)

  • McCall, K., Benencia, F., Kohn, L., Malgor, R., Schwartz, A., Schwartz, F. (2012). Toll-like Receptors as Novel Therapeutic Targets for the Treatment of Pancreatic Cancer. Sanjay Srivastava.