Ohio University

John Kopchick

John Kopchick Profile Picture
Professor, Molecular Biology
Fax: 740.593.4795
Konneker Research Center 206
Biomedical Engineering

Dr. Kopchick, the Milton and Lawrence H. Goll Eminent Scholar, is the university’s 2012 Distinguished Professor. Kopchick is known internationally for his 1989 discovery of a compound that became the basis for a drug that treats acromegaly, a disorder that can cause excessive growth of organs and bones, and can lead to premature death. The treatment has improved thousands of lives and has earned substantial royalties that support Ohio University research programs. In January, the Heritage College of Osteopathic Medicine announced that it would endow a research chair in honor of Kopchick.

Research Interests: Aging, Diabetes, Human Growth, Drug Design

All Degrees Earned: Ph.D., Biomedical Sciences, University of Texas, 1980. M.S., Biology/Chemistry, Indiana University of Pennsylvania, 1975. B.S., Biology, Indiana University of Pennsylvania, 1972.

Journal Article, Academic Journal (156)

  • List, E., Berryman, D., Basu, R., Buchman, M., Funk, K., Kulkarni, P., Duran-Ortiz, S., Qian, Y., Jensen, E., Young, J., Yildirim, G., Yakar, S., Kopchick, J. (2020). The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?. 8. Endocrinology; 161.
  • Young, J., Henry, B., Benencia, F., Bell, S., List, E., Kopchick, J., Berryman, D. (2020). GHR-/- Mice are protected from obesity-related white adipose tissue inflammation.. Journal of neuroendocrinology; e12854.
  • Jensen, E., Young, J., Jackson, Z., Busken, J., List, E., Carroll, R., Kopchick, J., Murphy, E., Berryman, D. (2020). Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice.. 4. Endocrinology; 161.
  • Kopchick, J., Berryman, D., Puri, V., Lee, K., Jorgensen JOL, . (2020). The effects of growth hormone on adipose tissue: old observations, new mechanisms.. 3. Nature reviews. Endocrinology; 16: 135-146.
  • Høyer, K., Høgild, M., List, E., Lee, K., Kissinger, E., Sharma, R., Erik Magnusson, N., Puri, V., Kopchick, J., Jørgensen JOL, ., Jessen, N. (2020). The acute effects of growth hormone in adipose tissue is associated with suppression of antilipolytic signals.. 3. Physiological reports; 8: e14373.
  • Colon, G., Saccon, T., Schneider, A., Cavalcante, M., Huffman, D., Berryman, D., List, E., Ikeno, Y., Musi, N., Bartke, A., Kopchick, J., Kirkland, J., Tchkonia, T., Masternak, M. (2019). The enigmatic role of growth hormone in age-related diseases, cognition, and longevity.. 6. GeroScience; 41: 759-774.
  • List, E., Berryman, D., Jensen, E., Kulkarni, P., McKenna, S., Kopchick, J. (2019). New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice.. 6. Archives of endocrinology and metabolism; 63: 557-567.
  • Hjelholt, A., Lee, K., Arlien-Søborg, M., Pedersen, S., Kopchick, J., Puri, V., Jessen, N., Jørgensen JOL, . (2019). Temporal patterns of lipolytic regulators in adipose tissue after acute growth hormone exposure in human subjects: A randomized controlled crossover trial.. Molecular metabolism; 29: 65-75.
  • Basu, R., Kulkarni, P., Qian, Y., Walsh, C., Arora, P., Davis, E., Duran-Ortiz, S., Funk, K., Ibarra, D., Kruse, C., Mathes, S., McHugh, T., Brittain, A., Berryman, D., List, E., Okada, S., Kopchick, J. (2019). Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma.. 9. Cancers; 11.
  • List, E., Berryman, D., Buchman, M., Jensen, E., Funk, K., Duran-Ortiz, S., Qian, Y., Young, J., Slyby, J., McKenna, S., Kopchick, J. (2019). GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.. 7. Endocrinology; 160: 1743-1756.
  • Swindell, W., Kruse CPS, ., List, E., Berryman, D., Kopchick, J. (2019). ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia.. 1. Journal of translational medicine; 17: 170.
  • List, E., Berryman, D., Buchman, M., Parker, C., Funk, K., Bell, S., Duran-Ortiz, S., Qian, Y., Young, J., Wilson, C., Slyby, J., McKenna, S., Jensen, E., Kopchick, J. (2019). Adipocyte-Specific GH Receptor-Null (AdGHRKO) Mice Have Enhanced Insulin Sensitivity With Reduced Liver Triglycerides.. 1. Endocrinology; 160: 68-80.
  • Young, J., Jensen, E., Stevens, A., Duran-Ortiz, S., List, E., Berryman, D., Kopchick, J. (2019). Characterization of an intestine-specific GH receptor knockout (IntGHRKO) mouse.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 46-47: 5-15.
  • Kruse CPS, ., Cottrill, D., Kopchick, J. (2019). Could calgranulins and advanced glycated end products potentiate acromegaly pathophysiology?. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 46-47: 1-4.
  • Sharma, V., Vestergaard, E., Jessen, N., Kolind-Thomsen, P., Nellemann, B., Nielsen, T., Vendelbo, M., Møller, N., Sharma, R., Lee, K., Kopchick, J., Jørgensen JOL, ., Puri, V. (2019). Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes.. 1. American journal of physiology. Endocrinology and metabolism; 316: E34-E42.
  • Liu, Z., Solesio, M., Schaffler, M., Frikha-Benayed, D., Rosen, C., Werner, H., Kopchick, J., Pavlov, E., Abramov, A., Yakar, S. (2019). Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice.. 1. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; 34: 106-122.
  • Sharma, R., Luong, Q., Sharma, V., Harberson, M., Harper, B., Colborn, A., Berryman, D., Jessen, N., Jørgensen JOL, ., Kopchick, J., Puri, V., Lee, K. (2018). Growth hormone controls lipolysis by regulation of FSP27 expression.. 3. The Journal of endocrinology; 239: 289-301.
  • Lozier, N., Kopchick, J., De Lacalle, S. (2018). Relative Contributions of Myostatin and the GH/IGF-1 Axis in Body Composition and Muscle Strength.. Frontiers in physiology; 9: 1418.
  • Buchman, M., Bell, S., Kopchick, J. (2018). Growth Hormone Discovery and Structure.. Suppl 1. Pediatric endocrinology reviews : PER; 16: 2-10.
  • Basu, R., Qian, Y., Kopchick, J. (2018). MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?. 5. European journal of endocrinology; 178: R155-R181.
  • Swindell, W., List, E., Berryman, D., Kopchick, J. (2018). Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue.. 4. Aging; 10: 701-746.
  • Hjortebjerg, R., Berryman, D., Comisford, R., List, E., Oxvig, C., Bjerre, M., Frystyk, J., Kopchick, J. (2018). Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 39: 54-61.
  • Hjortebjerg, R., Berryman, D., Comisford, R., List, E., Oxvig, C., Bjerre, M., Frystyk, J., Kopchick, J. (2018). Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 39: 54-61.
  • Householder, L., Comisford, R., Duran-Ortiz, S., Lee, K., Troike, K., Wilson, C., Jara, A., Harberson, M., List, E., Kopchick, J., Berryman, D. (2018). Increased fibrosis: A novel means by which GH influences white adipose tissue function.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 39: 45-53.
  • Johannsson, G., Bidlingmaier, M., Biller BMK, ., Boguszewski, M., Casanueva, F., Chanson, P., Clayton, P., Choong, C., Clemmons, D., Dattani, M., Frystyk, J., Ho, K., Hoffman, A., Horikawa, R., Juul, A., Kopchick, J., Luo, X., Neggers, S., Netchine, I., Olsson, D., Radovick, S., Rosenfeld, R., Ross, R., Schilbach, K., Solberg, P., Strasburger, C., Trainer, P., Yuen KCJ, ., Wickstrom, K., Jorgensen JOL, . (2018). Growth Hormone Research Society perspective on biomarkers of GH action in children and adults.. 3. Endocrine connections; 7: R126-R134.
  • Fang, Y., Hill, C., Darcy, J., Reyes-Ordoñez, A., Arauz, E., McFadden, S., Zhang, C., Osland, J., Gao, J., Zhang, T., Frank, S., Javors, M., Yuan, R., Kopchick, J., Sun, L., Chen, J., Bartke, A. (2018). Effects of rapamycin on growth hormone receptor knockout mice.. 7. Proceedings of the National Academy of Sciences of the United States of America; 115: E1495-E1503.
  • Duran-Ortiz, S., Noboa, V., Kopchick, J. (2018). Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 38: 3-7.
  • Nelson, C., List, E., Ieremia, M., Constantin, L., Chhabra, Y., Kopchick, J., Waters, M. (2018). Growth hormone activated STAT5 is required for induction of beige fat in vivo.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 42-43: 40-51.
  • Duran-Ortiz, S., Bell, S., Kopchick, J. (2018). Standardizing protocols dealing with growth hormone receptor gene disruption in mice using the Cre-lox system.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 42-43: 52-57.
  • Brittain, A., Basu, R., Qian, Y., Kopchick, J. (2017). Growth Hormone and the Epithelial-to-Mesenchymal Transition.. 10. The Journal of clinical endocrinology and metabolism; 102: 3662-3673.
  • Soendergaard, C., Kvist, P., Thygesen, P., Reslow, M., Nielsen, O., Kopchick, J., Holm, T. (2017). Characterization of Growth Hormone Resistance in Experimental and Ulcerative Colitis.. 10. International journal of molecular sciences; 18.
  • Consitt, L., Saneda, A., Saxena, G., List, E., Kopchick, J. (2017). Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass.. 1. Skeletal muscle; 7: 17.
  • Consitt, L., Saneda, A., Saxena, G., List, E., Kopchick, J. (2017). Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass.. 1. Skeletal muscle; 7: 17.
  • Gesing, A., Wiesenborn, D., Do, A., Menon, V., Schneider, A., Victoria, B., Stout, M., Kopchick, J., Bartke, A., Masternak, M. (2017). A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies.. 8. The journals of gerontology. Series A, Biological sciences and medical sciences; 72: 1054-1061.
  • Liu, Z., Han, T., Fishman, S., Butler, J., Zimmermann, T., Tremblay, F., Harbison, C., Agrawal, N., Kopchick, J., Schaffler, M., Yakar, S. (2017). Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth.. 8. Endocrinology; 158: 2556-2571.
  • Basu, A., McFarlane, H., Kopchick, J. (2017). Spatial learning and memory in male mice with altered growth hormone action.. Hormones and behavior; 93: 18-30.
  • Duran-Ortiz, S., Brittain, A., Kopchick, J. (2017). The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies.. Clinical proteomics; 14: 24.
  • Troike, K., Henry, B., Jensen, E., Young, J., List, E., Kopchick, J., Berryman, D. (2017). Impact of Growth Hormone on Regulation of Adipose Tissue.. 3. Comprehensive Physiology; 7: 819-840.
  • Hine, C., Kim, H., Zhu, Y., Harputlugil, E., Longchamp, A., Matos, M., Ramadoss, P., Bauerle, K., Brace, L., Asara, J., Ozaki, C., Cheng, S., Singha, S., Ahn, K., Kimmelman, A., Fisher, F., Pissios, P., Withers, D., Selman, C., Wang, R., Yen, K., Longo, V., Cohen, P., Bartke, A., Kopchick, J., Miller, R., Hollenberg, A., Mitchell, J. (2017). Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.. 6. Cell metabolism; 25: 1320-1333.e5.
  • Fang, Y., McFadden, S., Darcy, J., Hill, C., Huber, J., Verhulst, S., Kopchick, J., Miller, R., Sun, L., Bartke, A. (2017). Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice.. 3. GeroScience; 39: 347-356.
  • Basu, R., Baumgaertel, N., Wu, S., Kopchick, J. (2017). Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps.. 3. Hormones & cancer; 8: 143-156.
  • Soendergaard, C., Young, J., Kopchick, J. (2017). Growth Hormone Resistance-Special Focus on Inflammatory Bowel Disease.. 5. International journal of molecular sciences; 18.
  • Hjortebjerg, R., Berryman, D., Comisford, R., Frank, S., List, E., Bjerre, M., Frystyk, J., Kopchick, J. (2017). Insulin, IGF-1, and GH Receptors Are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice With Modified GH Action.. 5. Endocrinology; 158: 1406-1418.
  • Basu, R., Wu, S., Kopchick, J. (2017). Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways.. 13. Oncotarget; 8: 21579-21598.
  • Cady, G., Landeryou, T., Garratt, M., Kopchick, J., Qi, N., Garcia-Galiano, D., Elias, C., Myers, Jr, M., Miller, R., Sandoval, D., Sadagurski, M. (2017). Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons.. 5. Molecular metabolism; 6: 393-405.
  • Hascup, K., Lynn, M., Fitzgerald, P., Randall, S., Kopchick, J., Boger, H., Bartke, A., Hascup, E. (2017). Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging.. 3. The journals of gerontology. Series A, Biological sciences and medical sciences; 72: 329-337.
  • Bennis, M., Schneider, A., Victoria, B., Do, A., Wiesenborn, D., Spinel, L., Gesing, A., Kopchick, J., Siddiqi, S., Masternak, M. (2017). The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling.. 1. GeroScience; 39: 51-59.
  • Junnila, R., Duran-Ortiz, S., Suer, O., Sustarsic, E., Berryman, D., List, E., Kopchick, J. (2016). Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females.. 12. Endocrinology; 157: 4502-4513.
  • List, E., Jensen, E., Kowalski, J., Buchman, M., Berryman, D., Kopchick, J. (2016). Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice.. 1. Nutrition and healthy aging; 4: 95-99.
  • Christiansen, J., Backeljauw, P., Bidlingmaier, M., Biller, B., Boguszewski, M., Casanueva, F., Chanson, P., Chatelain, P., Choong, C., Clemmons, D., Cohen, L., Cohen, P., Frystyk, J., Grimberg, A., Hasegawa, Y., Haymond, M., Ho, K., Hoffman, A., Holly, J., Horikawa, R., Höybye, C., Jorgensen, J., Johannsson, G., Juul, A., Katznelson, L., Kopchick, J., Lee, K., Lee, K., Luo, X., Melmed, S., Miller, B., Misra, M., Popovic, V., Rosenfeld, R., Ross, J., Ross, R., Saenger, P., Strasburger, C., Thorner, M., Werner, H., Yuen, K. (2016). Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations.. 6. European journal of endocrinology; 174: C1-8.
  • Kopchick, J. (2016). Lessons learned from studies with the growth hormone receptor.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 28: 21-5.
  • Jara, A., Liu, X., Sim, D., Benner, C., Duran-Ortiz, S., Qian, Y., List, E., Berryman, D., Kim, J., Kopchick, J. (2016). Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice.. 5. Endocrinology; 157: 1929-41.
  • Bartke, A., List, E., Kopchick, J. (2016). The somatotropic axis and aging: Benefits of endocrine defects.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 27: 41-45.
  • Visser, W., Bombardieri, C., Zevenbergen, C., Barnhoorn, S., Ottaviani, A., van der Pluijm, I., Brandt, R., Kaptein, E., van Heerebeek, R., van Toor, H., Garinis, G., Peeters, R., Medici, M., van Ham, W., Vermeij, W., de Waard, M., de Krijger, R., Boelen, A., Kwakkel, J., Kopchick, J., List, E., Melis, J., Darras, V., Dollé, M., van der Horst, G., Hoeijmakers, J., Visser, T. (2016). Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.. 3. PloS one; 11: e0149941.
  • Hascup, E., Wang, F., Kopchick, J., Bartke, A. (2016). Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging.. 3. The journals of gerontology. Series A, Biological sciences and medical sciences; 71: 281-9.
  • Jørgensen, J., Kopchick, J., Bengtsson, B., Kappelgaard, A. (2016). Jens Sandahl Christiansen, DMSci, FRCPI (1948-2015).. 3. Pediatric endocrinology reviews : PER; 13: 567.
  • Spadaro, O., Goldberg, E., Camell, C., Youm, Y., Kopchick, J., Nguyen, K., Bartke, A., Sun, L., Dixit, V. (2016). Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.. 7. Cell reports; 14: 1571-1580.
  • Allen, D., Backeljauw, P., Bidlingmaier, M., Biller, B., Boguszewski, M., Burman, P., Butler, G., Chihara, K., Christiansen, J., Cianfarani, S., Clayton, P., Clemmons, D., Cohen, P., Darendeliler, F., Deal, C., Dunger, D., Erfurth, E., Fuqua, J., Grimberg, A., Haymond, M., Higham, C., Ho, K., Hoffman, A., Hokken-Koelega, A., Johannsson, G., Juul, A., Kopchick, J., Lee, P., Pollak, M., Radovick, S., Robison, L., Rosenfeld, R., Ross, R., Savendahl, L., Saenger, P., Toft Sorensen, H., Stochholm, K., Strasburger, C., Swerdlow, A., Thorner, M. (2016). GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults.. 2. European journal of endocrinology; 174: P1-9.
  • Young, J., List, E., Kopchick, J. (2016). Deconstructing the Growth Hormone Receptor(GHR): Physical and Metabolic Phenotypes of Tissue-Specific GHR Gene-Disrupted Mice.. Progress in molecular biology and translational science; 138: 27-39.
  • Brooks, N., Hjortebjerg, R., Henry, B., List, E., Kopchick, J., Berryman, D. (2016). Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 30-31: 22-30.
  • Liu, Y., Knop, E., Knop, N., Sullivan, D., List, E., Kopchick, J., Kam, W., Ding, J. (2016). Growth Hormone Influence on the Morphology and Size of the Mouse Meibomian Gland.. Journal of ophthalmology; 2016: 5728071.
  • Comisford, R., Lubbers, E., Householder, L., Suer, O., Tchkonia, T., Kirkland, J., List, E., Kopchick, J., Berryman, D. (2016). Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence.. 2. Gerontology; 62: 163-72.
  • Boguszewski, C., Boguszewski, M., Kopchick, J. (2016). Growth hormone, insulin-like growth factor system and carcinogenesis.. 4. Endokrynologia Polska; 67: 414-26.
  • Jara, A., Kopchick, J. (2016). Young at Heart.. 1. Endocrinology; 157: 44-5.
  • Sadagurski, M., Landeryou, T., Cady, G., Kopchick, J., List, E., Berryman, D., Bartke, A., Miller, R. (2015). Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice.. 6. Aging cell; 14: 1045-54.
  • Stout, M., Swindell, W., Zhi, X., Rohde, K., List, E., Berryman, D., Kopchick, J., Gesing, A., Fang, Y., Masternak, M. (2015). Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice.. 29. Oncotarget; 6: 26702-15.
  • Cordoba-Chacon, J., Majumdar, N., List, E., Diaz-Ruiz, A., Frank, S., Manzano, A., Bartrons, R., Puchowicz, M., Kopchick, J., Kineman, R. (2015). Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice.. 9. Diabetes; 64: 3093-103.
  • Longo, V., Antebi, A., Bartke, A., Barzilai, N., Brown-Borg, H., Caruso, C., Curiel, T., de Cabo, R., Franceschi, C., Gems, D., Ingram, D., Johnson, T., Kennedy, B., Kenyon, C., Klein, S., Kopchick, J., Lepperdinger, G., Madeo, F., Mirisola, M., Mitchell, J., Passarino, G., Rudolph, K., Sedivy, J., Shadel, G., Sinclair, D., Spindler, S., Suh, Y., Vijg, J., Vinciguerra, M., Fontana, L. (2015). Interventions to Slow Aging in Humans: Are We Ready?. 4. Aging cell; 14: 497-510.
  • López-Villar, E., Martos-Moreno, G., Chowen, J., Okada, S., Kopchick, J., Argente, J. (2015). A proteomic approach to obesity and type 2 diabetes.. 7. Journal of cellular and molecular medicine; 19: 1455-70.
  • Olarescu, N., Berryman, D., Householder, L., Lubbers, E., List, E., Benencia, F., Kopchick, J., Bollerslev, J. (2015). GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells.. 1. The Journal of endocrinology; 226: 13-23.
  • List, E., Berryman, D., Ikeno, Y., Hubbard, G., Funk, K., Comisford, R., Young, J., Stout, M., Tchkonia, T., Masternak, M., Bartke, A., Kirkland, J., Miller, R., Kopchick, J. (2015). Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.. 7. Aging; 7: 500-12.
  • Arum, O., Dawson, J., Smith, Jr, D., Kopchick, J., Allison, D., Bartke, A. (2015). Do altered energy metabolism or spontaneous locomotion 'mediate' decelerated senescence?. 3. Aging cell; 14: 483-90.
  • Benencia, F., Harshman, S., Duran-Ortiz, S., Lubbers, E., List, E., Householder, L., Al-Naeeli, M., Liang, X., Welch, L., Kopchick, J., Berryman, D. (2015). Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations.. 5. Endocrinology; 156: 1794-803.
  • Bartke, A., Kopchick, J. (2015). The forgotten lactogenic activity of growth hormone: important implications for rodent studies.. 5. Endocrinology; 156: 1620-2.
  • Lim, S., Marenzana, M., Hopkinson, M., List, E., Kopchick, J., Pereira, M., Javaheri, B., Roux, J., Chavassieux, P., Korbonits, M., Chenu, C. (2015). Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength.. 4. Endocrinology; 156: 1362-71.
  • Zawada, I., Masternak, M., List, E., Stout, M., Berryman, D., Lewinski, A., Kopchick, J., Bartke, A., Karbownik-Lewinska, M., Gesing, A. (2015). Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.. 3. Aging; 7: 195-204.
  • Christensen, B., Ludvigsen, M., Nellemann, B., Kopchick, J., Honoré, B., Jørgensen, J. (2015). Serum proteomic changes after randomized prolonged erythropoietin treatment and/or endurance training: detection of novel biomarkers.. 2. PloS one; 10: e0117119.
  • Yang, T., Householder, L., Lubbers, E., List, E., Troike, K., Vesel, C., Duran-Ortiz, S., Kopchick, J., Berryman, D. (2015). Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet.. 2. Endocrinology; 156: 555-64.
  • Dominick, G., Berryman, D., List, E., Kopchick, J., Li , X., Miller, R., Garcia, G. (2015). Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice.. 2. Endocrinology; 156: 565-75.
  • Gesing, A., Wang, F., List, E., Berryman, D., Masternak, M., Lewinski, A., Karbownik-Lewinska, M., Kopchick, J., Bartke, A. (2015). Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent.. 1. The journals of gerontology. Series A, Biological sciences and medical sciences; 70: 44-52.
  • Brown-Borg, H., Rakoczy, S., Wonderlich, J., Rojanathammanee, L., Kopchick, J., Armstrong, V., Raasakka, D. (2014). Growth hormone signaling is necessary for lifespan extension by dietary methionine.. 6. Aging cell; 13: 1019-27.
  • Arum, O., Boparai, R., Saleh, J., Wang, F., Dirks, A., Turner, J., Kopchick, J., Liu, J., Khardori, R., Bartke, A. (2014). Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging.. 6. Aging cell; 13: 981-1000.
  • Baquedano, E., Ruiz-Lopez, A., Sustarsic, E., Herpy, J., List, E., Chowen, J., Frago, L., Kopchick, J., Argente, J. (2014). The absence of GH signaling affects the susceptibility to high-fat diet-induced hypothalamic inflammation in male mice.. 12. Endocrinology; 155: 4856-67.
  • Stout, M., Tchkonia, T., Pirtskhalava, T., Palmer, A., List, E., Berryman, D., Lubbers, E., Escande, C., Spong, A., Masternak, M., Oberg, A., LeBrasseur, N., Miller, R., Kopchick, J., Bartke, A., Kirkland, J. (2014). Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.. 7. Aging; 6: 575-86.
  • Cheng, C., Adams, G., Perin, L., Wei, M., Zhou, X., Lam, B., Da Sacco, S., Mirisola, M., Quinn, D., Dorff, T., Kopchick, J., Longo, V. (2014). Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.. 6. Cell stem cell; 14: 810-23.
  • Arum, O., Saleh, J., Boparai, R., Kopchick, J., Khardori, R., Bartke, A. (2014). Preservation of blood glucose homeostasis in slow-senescing somatotrophism-deficient mice subjected to intermittent fasting begun at middle or old age.. 3. Age (Dordrecht, Netherlands); 36: 9651.
  • List, E., Berryman, D., Funk, K., Jara, A., Kelder, B., Wang, F., Stout, M., Zhi, X., Sun, L., White, T., LeBrasseur, N., Pirtskhalava, T., Tchkonia, T., Jensen, E., Zhang, W., Masternak, M., Kirkland, J., Miller, R., Bartke, A., Kopchick, J. (2014). Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles.. 5. Endocrinology; 155: 1793-805.
  • Kopchick, J., List, E., Kelder, B., Gosney, E., Berryman, D. (2014). Evaluation of growth hormone (GH) action in mice: discovery of GH receptor antagonists and clinical indications.. 1-2. Molecular and cellular endocrinology; 386: 34-45.
  • Jara, A., Benner, C., Sim, D., Liu, X., List, E., Householder, L., Berryman, D., Kopchick, J. (2014). Elevated systolic blood pressure in male GH transgenic mice is age dependent.. 3. Endocrinology; 155: 975-86.
  • Hong, S., Longo, K., Gosney, E., Kopchick, J. (2014). Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model.. 3. The journals of gerontology. Series A, Biological sciences and medical sciences; 69: 274-81.
  • Berryman, D., Lubbers, E., Magon, V., List, E., Kopchick, J. (2014). A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age.. 2. The journals of gerontology. Series A, Biological sciences and medical sciences; 69: 131-41.
  • Nielsen, R., Clausen, N., Schjerling, P., Larsen, J., Martinussen, T., List, E., Kopchick, J., Kjaer, M., Heinemeier, K. (2014). Chronic alterations in growth hormone/insulin-like growth factor-I signaling lead to changes in mouse tendon structure.. Matrix biology : journal of the International Society for Matrix Biology; 34: 96-104.
  • Arum, O., Rickman, D., Kopchick, J., Bartke, A. (2014). The slow-aging growth hormone receptor/binding protein gene-disrupted (GHR-KO) mouse is protected from aging-resultant neuromusculoskeletal frailty.. 1. Age (Dordrecht, Netherlands); 36: 117-27.
  • Sackmann-Sala, L., Berryman, D., Lubbers, E., Zhang, H., Vesel, C., Troike, K., Gosney, E., List, E., Kopchick, J. (2014). Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice.. 1. The journals of gerontology. Series A, Biological sciences and medical sciences; 69: 34-43.
  • Schneider, A., Zhi, X., Bartke, A., Kopchick, J., Masternak, M. (2014). Effect of growth hormone receptor gene disruption and PMA treatment on the expression of genes involved in primordial follicle activation in mice ovaries.. 4. Age (Dordrecht, Netherlands); 36: 9701.
  • Martos-Moreno, G., Sackmann-Sala, L., Barrios, V., Berrymann, D., Okada, S., Argente, J., Kopchick, J. (2014). Proteomic analysis allows for early detection of potential markers of metabolic impairment in very young obese children.. 1. International journal of pediatric endocrinology; 2014: 9.
  • Sustarsic, E., Junnila, R., Kopchick, J. (2013). Human metastatic melanoma cell lines express high levels of growth hormone receptor and respond to GH treatment.. 1. Biochemical and biophysical research communications; 441: 144-50.
  • Li , X., Bartke, A., Berryman, D., Funk, K., Kopchick, J., List, E., Sun, L., Miller, R. (2013). Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes.. 8. American journal of physiology. Endocrinology and metabolism; 305: E942-50.
  • Piotrowska, K., Borkowska, S., Wiszniewska, B., Laszczyńska, M., Słuczanowska-Głabowska, S., Havens, A., Kopchick, J., Bartke, A., Taichman, R., Kucia, M., Ratajczak, M. (2013). The effect of low and high plasma levels of insulin-like growth factor-1 (IGF-1) on the morphology of major organs: studies of Laron dwarf and bovine growth hormone transgenic (bGHTg) mice.. 10. Histology and histopathology; 28: 1325-36.
  • Słuczanowska-Głąbowska, S., Laszczyńska, M., Piotrowska, K., Głąbowski, W., Rumianowski, B., Masternak, M., Arum, O., Kucia, M., Kopchick, J., Bartke, A., Ratajczak, M. (2013). The effect of calorie restriction on the presence of apoptotic ovarian cells in normal wild type mice and low-plasma-IGF-1 Laron dwarf mice.. 1. Journal of ovarian research; 6: 67.
  • List, E., Berryman, D., Wright-Piekarski, J., Jara, A., Funk, K., Kopchick, J. (2013). The effects of weight cycling on lifespan in male C57BL/6J mice.. 8. International journal of obesity (2005); 37: 1088-94.
  • Gesing, A., Masternak, M., Lewinski, A., Karbownik-Lewinska, M., Kopchick, J., Bartke, A. (2013). Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.. 6. The journals of gerontology. Series A, Biological sciences and medical sciences; 68: 639-51.
  • Junnila, R., List, E., Berryman, D., Murrey, J., Kopchick, J. (2013). The GH/IGF-1 axis in ageing and longevity.. 6. Nature reviews. Endocrinology; 9: 366-376.
  • Kucia, M., Masternak, M., Liu, R., Shin, D., Ratajczak, J., Mierzejewska, K., Spong, A., Kopchick, J., Bartke, A., Ratajczak, M. (2013). The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs).. 2. Age (Dordrecht, Netherlands); 35: 315-30.
  • Martos-Moreno, G., Kopchick, J., Argente, J. (2013). [Adipokines in healthy and obese children].. 3. Anales de pediatria (Barcelona, Spain : 2003); 78: 189.e1-189.e15.
  • Martos-Moreno, G., Sackmann-Sala, L., Berryman, D., Blome, D., Argente, J., Kopchick, J. (2013). [Anatomical heterogeneity in the proteome of human subcutaneous adipose tissue].. 3. Anales de pediatria (Barcelona, Spain : 2003); 78: 140-8.
  • List, E., Berryman, D., Funk, K., Gosney, E., Jara, A., Kelder, B., Wang, X., Kutz, L., Troike, K., Lozier, N., Mikula, V., Lubbers, E., Zhang, H., Vesel, C., Junnila, R., Frank, S., Masternak, M., Bartke, A., Kopchick, J. (2013). The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice.. 3. Molecular endocrinology (Baltimore, Md.); 27: 524-35.
  • Lubbers, E., List, E., Jara, A., Sackman-Sala, L., Cordoba-Chacon, J., Gahete, M., Kineman, R., Boparai, R., Bartke, A., Kopchick, J., Berryman, D. (2013). Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?. 3. The Journal of endocrinology; 216: 363-74.
  • Ding, J., Sackmann-Sala, L., Kopchick, J. (2013). Mouse models of growth hormone action and aging: a proteomic perspective.. 3-4. Proteomics; 13: 674-85.
  • Luca, G., Calvitti, M., Mancuso, F., Falabella, G., Arato, I., Bellucci, C., List, E., Bellezza, E., Angeli, G., Lilli, C., Bodo, M., Becchetti, E., Kopchick, J., Cameron, D., Baroni, T., Calafiore, R. (2013). Reversal of experimental Laron Syndrome by xenotransplantation of microencapsulated porcine Sertoli cells.. 1. Journal of controlled release : official journal of the Controlled Release Society; 165: 75-81.
  • Junnila, R., Kopchick, J. (2013). Significance of the disulphide bonds of human growth hormone.. 4. Endokrynologia Polska; 64: 300-5.
  • Giani, J., Miquet, J., Muñoz, M., Burghi, V., Toblli, J., Masternak, M., Kopchick, J., Bartke, A., Turyn, D., Dominici, F. (2012). Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice.. 6. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 22: 224-33.
  • Burgos-Ramos, E., Sackmann-Sala, L., Baquedano, E., Cruz-Topete, D., Barrios, V., Argente, J., Kopchick, J. (2012). Central leptin and insulin administration modulates serum cytokine- and lipoprotein-related markers.. 11. Metabolism: clinical and experimental; 61: 1646-57.
  • Sackmann-Sala, L., Berryman, D., Lubbers, E., Vesel, C., Troike, K., List, E., Munn, R., Ikeno, Y., Kopchick, J. (2012). Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice.. 5. Age (Dordrecht, Netherlands); 34: 1225-37.
  • Ding, J., Berryman, D., Jara, A., Kopchick, J. (2012). Age- and sex-associated plasma proteomic changes in growth hormone receptor gene-disrupted mice.. 8. The journals of gerontology. Series A, Biological sciences and medical sciences; 67: 830-40.
  • Słuczanowska-Głąbowska, S., Laszczyńska, M., Piotrowska, K., Głąbowski, W., Kopchick, J., Bartke, A., Kucia, M., Ratajczak, M. (2012). Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1.. Journal of ovarian research; 5: 18.
  • Masternak, M., Bartke, A., Wang, F., Spong, A., Gesing, A., Fang, Y., Salmon, A., Hughes, L., Liberati, T., Boparai, R., Kopchick, J., Westbrook, R. (2012). Metabolic effects of intra-abdominal fat in GHRKO mice.. 1. Aging cell; 11: 73-81.
  • Christensen, B., Lundby, C., Jessen, N., Nielsen, T., Vestergaard, P., Møller, N., Pilegaard, H., Pedersen, S., Kopchick, J., Jørgensen, J. (2012). Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects.. 2. PloS one; 7: e31857.
  • Sackmann-Sala, L., Berryman, D., Munn, R., Lubbers, E., Kopchick, J. (2012). Heterogeneity among white adipose tissue depots in male C57BL/6J mice.. 1. Obesity (Silver Spring, Md.); 20: 101-11.
  • Ding, J., Berryman, D., Kopchick, J. (2011). Plasma proteomic profiles of bovine growth hormone transgenic mice as they age.. 6. Transgenic research; 20: 1305-20.
  • Liang, R., Khanna, A., Muthusamy, S., Li , N., Sarojini, H., Kopchick, J., Masternak, M., Bartke, A., Wang, E. (2011). Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice.. 6. Aging cell; 10: 1080-8.
  • Ding, J., List, E., Bower, B., Kopchick, J. (2011). Differential effects of growth hormone versus insulin-like growth factor-I on the mouse plasma proteome.. 10. Endocrinology; 152: 3791-802.
  • Longo, K., Govek, E., Nolan, A., McDonagh, T., Charoenthongtrakul, S., Giuliana, D., Morgan, K., Hixon, J., Zhou, C., Kelder, B., Kopchick, J., Saunders, J., Navia, M., Curtis, R., DiStefano, P., Geddes, B. (2011). Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity.. 1. The Journal of pharmacology and experimental therapeutics; 339: 115-24.
  • Ding, J., Okada, S., Jørgensen, J., Kopchick, J. (2011). Novel serum protein biomarkers indicative of growth hormone doping in healthy human subjects.. 17. Proteomics; 11: 3565-71.
  • Ding, J., Kopchick, J. (2011). Plasma biomarkers of mouse aging.. 3. Age (Dordrecht, Netherlands); 33: 291-307.
  • Martin, B., List, E., Kopchick, J., Sauvé, Y., Harvey, S. (2011). Selective inner retinal dysfunction in growth hormone transgenic mice.. 4. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 21: 219-27.
  • Zerrad-Saadi, A., Lambert-Blot, M., Mitchell, C., Bretes, H., de Collin l'Hortet, A., Baud, V., Chereau, F., Sotiropoulos, A., Kopchick, J., Liao, L., Xu, J., Gilgenkrantz, H., Guidotti, J. (2011). GH receptor plays a major role in liver regeneration through the control of EGFR and ERK1/2 activation.. 7. Endocrinology; 152: 2731-41.
  • Cruz-Topete, D., Jorgensen, J., Christensen, B., Sackmann-Sala, L., Krusenstjerna-Hafstrøm, T., Jara, A., Okada, S., Kopchick, J. (2011). Identification of new biomarkers of low-dose GH replacement therapy in GH-deficient patients.. 7. The Journal of clinical endocrinology and metabolism; 96: 2089-97.
  • List, E., Sackmann-Sala, L., Berryman, D., Funk, K., Kelder, B., Gosney, E., Okada, S., Ding, J., Cruz-Topete, D., Kopchick, J. (2011). Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.. 3. Endocrine reviews; 32: 356-86.
  • Berryman, D., List, E., Sackmann-Sala, L., Lubbers, E., Munn, R., Kopchick, J. (2011). Growth hormone and adipose tissue: beyond the adipocyte.. 3. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 21: 113-23.
  • Cruz-Topete, D., List, E., Okada, S., Kelder, B., Kopchick, J. (2011). Proteomic changes in the heart of diet-induced pre-diabetic mice.. 5. Journal of proteomics; 74: 716-27.
  • Cruz-Topete, D., Christensen, B., Sackmann-Sala, L., Okada, S., Jorgensen, J., Kopchick, J. (2011). Serum proteome changes in acromegalic patients following transsphenoidal surgery: novel biomarkers of disease activity.. 2. European journal of endocrinology; 164: 157-67.
  • Fukushima, T., Arai, T., Ariga-Nedachi, M., Okajima, H., Ooi, Y., Iijima, Y., Sone, M., Cho, Y., Ando, Y., Kasahara, K., Ozoe, A., Yoshihara, H., Chida, K., Okada, S., Kopchick, J., Asano, T., Hakuno, F., Takahashi, S. (2011). Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.. 3. Biochemical and biophysical research communications; 404: 767-73.
  • Neggers, S., Kopchick, J., Jørgensen, J., van der Lely, A. (2011). Hypothesis: Extra-hepatic acromegaly: a new paradigm?. 1. European journal of endocrinology; 164: 11-6.
  • Xu, J., Okada, S., Tan, L., Goodrum, K., Kopchick, J., Kieliszewski, M. (2010). Human growth hormone expressed in tobacco cells as an arabinogalactan-protein fusion glycoprotein has a prolonged serum life.. 5. Transgenic research; 19: 849-67.
  • Coschigano, K., Wetzel, A., Obichere, N., Sharma, A., Lee, S., Rasch, R., Guigneaux, M., Flyvbjerg, A., Wood, T., Kopchick, J. (2010). Identification of differentially expressed genes in the kidneys of growth hormone transgenic mice.. 5. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 20: 345-55.
  • Coschigano, K., Wetzel, A., Obichere, N., Sharma, A., Lee, S., Rasch, R., Guigneaux, M., Flyvbjerg, A., Wood, T., Kopchick, J. (2010). Identification of differentially expressed genes in the kidneys of growth hormone transgenic mice.. 5. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 20: 345-55.
  • Rouet, V., Bogorad, R., Kayser, C., Kessal, K., Genestie, C., Bardier, A., Grattan, D., Kelder, B., Kopchick, J., Kelly, P., Goffin, V. (2010). Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors.. 34. Proceedings of the National Academy of Sciences of the United States of America; 107: 15199-204.
  • Doi, S., Chilakamarri, G., Mendonca, M., Araujo, M., Nguyen, N., Zuhl, I., List, E., Kopchick, J., Hirata, M., Sellitti, D. (2010). Increased class A scavenger receptor and glomerular lipid precede mesangial matrix expansion in the bGH mouse model.. 4. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 20: 326-32.
  • Okada, S., List, E., Sankaran, S., Kopchick, J. (2010). Plasma Protein Biomarkers Correlated with the Development of Diet-Induced Type 2 Diabetes in Mice.. 1-2. Clinical proteomics; 6: 6-17.
  • Callewaert, F., Venken, K., Kopchick, J., Torcasio, A., van Lenthe, G., Boonen, S., Vanderschueren, D. (2010). Sexual dimorphism in cortical bone size and strength but not density is determined by independent and time-specific actions of sex steroids and IGF-1: evidence from pubertal mouse models.. 3. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research; 25: 617-26.
  • Longo, K., Berryman, D., Kelder, B., Charoenthongtrakul, S., Distefano, P., Geddes, B., Kopchick, J. (2010). Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency.. 1. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 20: 73-9.
  • Berryman, D., List, E., Palmer, A., Chung, M., Wright-Piekarski, J., Lubbers, E., O'Connor, P., Okada, S., Kopchick, J. (2010). Two-year body composition analyses of long-lived GHR null mice.. 1. The journals of gerontology. Series A, Biological sciences and medical sciences; 65: 31-40.
  • Sackmann-Sala, L., Ding, J., Frohman, L., Kopchick, J. (2009). Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.. 6. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 19: 471-7.
  • Izzard, A., Emerson, M., Prehar, S., Neyses, L., Trainer, P., List, E., Kopchick, J., Heagerty, A. (2009). The cardiovascular phenotype of a mouse model of acromegaly.. 5. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 19: 413-9.
  • List, E., Palmer, A., Berryman, D., Bower, B., Kelder, B., Kopchick, J. (2009). Growth hormone improves body composition, fasting blood glucose, glucose tolerance and liver triacylglycerol in a mouse model of diet-induced obesity and type 2 diabetes.. 8. Diabetologia; 52: 1647-55.
  • Ding, J., List, E., Okada, S., Kopchick, J. (2009). Perspective: proteomic approach to detect biomarkers of human growth hormone.. 4. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 19: 399-407.
  • Fan, Y., Menon, R., Cohen, P., Hwang, D., Clemens, T., DiGirolamo, D., Kopchick, J., Le Roith, D., Trucco, M., Sperling, M. (2009). Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.. 30. The Journal of biological chemistry; 284: 19937-44.
  • Kraemer, W., Vingren, J., Schuenke, M., Kopchick, J., Volek, J., Fragala, M., Häkkinen, K., Jen-Ho, ., Thomas, G., Staron, R. (2009). Effect of circulating growth hormone on muscle IGF-I protein concentration in female mice with growth hormone receptor gene disruption.. 3. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 19: 242-4.
  • Swindell, W., Masternak, M., Kopchick, J., Conover, C., Bartke, A., Miller, R. (2009). Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice.. 6. Mechanisms of ageing and development; 130: 393-400.
  • Ikeno, Y., Hubbard, G., Lee, S., Cortez, L., Lew, C., Webb, C., Berryman, D., List, E., Kopchick, J., Bartke, A. (2009). Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice.. 5. The journals of gerontology. Series A, Biological sciences and medical sciences; 64: 522-9.
  • Nass, R., Johannsson, G., Christiansen, J., Kopchick, J., Thorner, M. (2009). The aging population--is there a role for endocrine interventions?. 2. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 19: 89-100.
  • Palmer, A., Chung, M., List, E., Walker, J., Okada, S., Kopchick, J., Berryman, D. (2009). Age-related changes in body composition of bovine growth hormone transgenic mice.. 3. Endocrinology; 150: 1353-60.
  • Bonkowski, M., Dominici, F., Arum, O., Rocha, J., Al Regaiey, K., Westbrook, R., Spong, A., Panici, J., Masternak, M., Kopchick, J., Bartke, A. (2009). Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity.. 2. PloS one; 4: e4567.
  • Stevenson, A., Evans, B., Gevers, E., Elford, C., McLeod, R., Perry, M., El-Kasti, M., Coschigano, K., Kopchick, J., Evans, S., Wells, T. (2009). Does adiposity status influence femoral cortical strength in rodent models of growth hormone deficiency?. 1. American journal of physiology. Endocrinology and metabolism; 296: E147-56.
  • Stevenson, A., Evans, B., Gevers, E., Elford, C., McLeod, R., Perry, M., El-Kasti, M., Coschigano, K., Kopchick, J., Evans, S., Wells, T. (2009). Does adiposity status influence femoral cortical strength in rodent models of growth hormone deficiency?. 1. American journal of physiology. Endocrinology and metabolism; 296: E147-56.

Abstract (9)

  • List, E., Berryman, D., Funk, F., Bell, S., Duran Ortiz, S., Young, J., Jensen, E., Qian, Y., Slyby, J., McKenna, S., Kopchick, J. (2019). Adipocyte-Specific GH Receptor Knockout Mice (AdGHRKO) Have Enhanced Insulin Sensitivity with Reduced Liver Triglycerides and Depot Specific Analyses in These Mice Suggest that GH May Have a More Substantial Effect on Subcutaneous White Adipose Tissue (WAT) Than Other WAT Depots. 1. Journal of the Endocrine Society; 3.
  • Slyby, J., McKenna, S., Mitchell, J., Duran-Ortiz, S., Young, J., Qian, Q., Berryman, D., Kopchick, J., List, E. (2019). Altering Cycle Duration Of A Yoyo-diet Has No Effect On Mortality In Weight Cycled Mice. 1. Journal of the Endocrine Society; 3.
  • Duran-Ortiz, S., List, E., Berryman, D., Bell, S., Funk, F., Basu, R., Qian, Q., Young, J., Kopchick, J. (2019). Characterization of Adult Growth Hormone Receptor Gene-Disrupted Mice. 1. Journal of the Endocrine Society; 3.
  • Geitgey, D., Savin, S., Mahler, I., Yaron-Saminsky, D., List, E., Kopchick, J., Laron, Z., Berryman, D. (2019). Depot-Specific Differences in Adipose Tissue Morphology with Laron Syndrome . 1. Journal of the Endocrine Society; 3.
  • Qian, Q., Basu, R., Mathes, S., Arnett, N., Duran-Ortiz, S., Kruse, C., Brittain, A., Funk, F., Terry, J., Smith, C., Henry, B., Bell, S., List, E., Berryman, D., Kopchick, J. (2019). GH Action Upregulates ABC Transporters And EMT Markers In A Syngeneic Melanoma Mouse Model. 1. Journal of the Endocrine Society; 3.
  • Young, J., Jensen, E., Jackson, Z., Busken, J., Kuhn, J., List, E., Berryman, D., Kopchick, J. (2019). Gross and Microscopic Intestinal Morphology of Bovine Growth Hormone Transgenic Mice Longitudinally. 1. Journal of the Endocrine Society; 3.
  • Jensen, J., Jackson, J., Busken, J., Young, J., Kuhn, J., Carroll, R., List, E., Murphy, E., Kopchick, J., Berryman, D. (2019). Growth Hormone (GH) Impacts the Gut Microbial Profile: the Presence of Unique Bacterial Genera in Mouse Lines with Altered GH Action. 1. 3.
  • Mathes, S., Qian, Q., Basu, R., Arnett, N., Duran-Ortiz, S., Kruse, C., Brittain, A., Funk, F., Terry, J., Smith, C., Bell, S., List, E., Berryman, D., Kopchick, J. (2019). Growth Hormone Receptor (GHR) Antagonism Suppresses Hepatocellular Carcinoma Growth in a Syngeneic Mouse Model . 1. Journal of the Endocrine Society; 3.
  • Funk, F., Qian, Y., List, E., Berryman, D., Kopchick, J. (2019). Reduced Respiration Observed In Isolated Liver Mitochondria Of Long-lived GHR-/- Mice At Early Ages. 1. Journal of the Endocrine Society; 3.

Other (6)

  • Furigo, I., Teixeira PDS, ., de Souza, G., Couto GCL, ., Romero, G., Perelló, M., Frazão, R., Elias, L., Metzger, M., List, E., Kopchick, J., Donato, Jr, J. (2019). Author Correction: Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons.. 1. Nature communications; 10: 980.
  • Kopchick, J., Johannsson, G. (2017). Meeting Reports: The 25th Anniversary of the Growth Hormone Research Society Lisbon, Portugal, May 20, 2017.. 1. Pediatric endocrinology reviews : PER; 15: 53-56.
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