Ohio University

Brian Clark

Brian Clark Profile Picture
Professor, Physiology & Neuroscience; Harold E. Clybourne, D.O., Endowed Research Chair
Irvine Hall 236
Biomedical Engineering

Research Interests: translational physiology

Journal Article, Academic Journal (87)

  • Tavoian, D., Russ, D., Consitt, L., Clark, B. (2020). Perspective: Pragmatic Exercise Recommendations for Older Adults: The Case for Emphasizing Resistance Training.. Frontiers in physiology; 11: 799.
  • McGrath, R., Cawthon, P., Cesari, M., Al Snih, S., Clark, B. (2020). Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study.. Journal of the American Geriatrics Society.
  • McGrath, R., Vincent, B., Hackney, K., Robinson-Lane, S., Downer, B., Clark, B. (2020). The Longitudinal Associations of Handgrip Strength and Cognitive Function in Aging Americans.. 5. Journal of the American Medical Directors Association; 21: 634-639.e1.
  • McGrath, R., Vincent, B., Peterson, M., Jurivich, D., Dahl, L., Hackney, K., Clark, B. (2020). Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis.. 5. Journal of the American Medical Directors Association; 21: 621-626.e2.
  • Wernbom, M., Schoenfeld, B., Paulsen, G., Bjørnsen, T., Cumming, K., Aagaard, P., Clark, B., Raastad, T. (2020). Commentary: Can Blood Flow Restricted Exercise Cause Muscle Damage? Commentary on Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety.. Frontiers in physiology; 11: 243.
  • Shaughnessy, K., Hackney, K., Clark, B., Kraemer, W., Terbizan, D., Bailey, R., McGrath, R. (2020). A Narrative Review of Handgrip Strength and Cognitive Functioning: Bringing a New Characteristic to Muscle Memory.. 4. Journal of Alzheimer's disease : JAD; 73: 1265-1278.
  • McGrath, R., Hackney, K., Ratamess, N., Vincent, B., Clark, B., Kraemer, W. (2020). Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans.. 1. Advances in geriatric medicine and research; 2.
  • Tavoian, D., Russ, D., Law, T., Simon, J., Chase, P., Guseman, E., Clark, B. (2019). A Randomized Clinical Trial Comparing Three Different Exercise Strategies for Optimizing Aerobic Capacity and Skeletal Muscle Performance in Older Adults: Protocol for the DART Study.. Frontiers in medicine; 6: 236.
  • Oki, K., Clark, L., Amano, S., Clark, B. (2019). Effect of Anodal Transcranial Direct Current Stimulation of the Motor Cortex on Elbow Flexor Muscle Strength in the Very Old.. 4. Journal of geriatric physical therapy (2001); 42: 243-248.
  • Arnold, W., Clark, B. (2019). Faster, higher, farther: outpacing age-related motor neuron losses.. 19. The Journal of physiology; 597: 4867-4868.
  • Chen, H., Han, Y., Jahan, I., Wu, S., Clark, B., Wiseman, J. (2019). Extracts of maca (Lepidium meyenii) root induce increased glucose uptake by inhibiting mitochondrial function in an adipocyte cell line. Journal of Herbal Medicine; http://www.ncbi.nlm.nih.gov/pubmed/?term=The+Effect+of+Endothelial+Cells+on+UVB-induced+DNA+Damage+and+Transformation+of+Keratinocytes+In+3D+Polycaprolactone+Scaffold+Co-culture+System.
  • Oki , K., Clark , L., Amani , S., Clark, B. (2019). Effect of anodal transcranial direct current stimulation of the motor cortex on elbow flexor strength in the very old.
  • Clark, B., Manini, T., Wages, N., Simon, J., Clark, L. (2019). Voluntary vs Electrically Stimulated Activation in Age-Related Muscle Weakness.. 9. JAMA network open; 2: e1912052.
  • Tavoian, D., Ampomah, K., Amano, S., Law, T., Clark, B. (2019). Changes in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated.. 1. Scientific reports; 9: 10028.
  • Lau, H., Mat Ludin, A., Shahar, S., Badrasawi, M., Clark, B. (2019). Factors associated with motoric cognitive risk syndrome among low-income older adults in Malaysia.. Suppl 4. BMC public health; 19: 462.
  • Mahato, N., Montuelle, S., Clark, B. (2019). Assessment of In Vivo Lumbar Inter-Vertebral Motion: Reliability of a Novel Dynamic Weight-Bearing Magnetic Resonance Imaging Technique Using a Side-Bending Task.. 3. Asian spine journal; 13: 377-385.
  • McGrath, R., Clark, B., Erlandson, K., Herrmann, S., Vincent, B., Hall, O., Hackney, K. (2019). Impairments in Individual Autonomous Living Tasks and Time to Self-Care Disability in Middle-Aged and Older Adults.. 6. Journal of the American Medical Directors Association; 20: 730-735.e3.
  • Ampomah, K., Amano, S., Wages, N., Volz, L., Clift, R., Ludin, A., Nakazawa, M., Law, T., Manini, T., Thomas, J., Russ, D., Clark, B. (2019). Blood Flow–restricted Exercise Does Not Induce a Cross-transfer of Effect: An RCT. Medicine & Science in Sports & Exercise; 1. http://Insights.ovid.com/crossref?an=00005768-900000000-96643.
  • McGrath, R., Erlandson, K., Vincent, B., Hackney, K., Herrmann, S., Clark, B. (2019). Decreased Handgrip Strength is Associated With Impairments in Each Autonomous Living Task for Aging Adults in the United States.. 3. The Journal of frailty & aging; 8: 141-145.
  • McGrath, R., Robinson-Lane, S., Cook, S., Clark, B., Herrmann, S., O'Connor, M., Hackney, K. (2019). Handgrip Strength Is Associated with Poorer Cognitive Functioning in Aging Americans.. 4. Journal of Alzheimer's disease : JAD; 70: 1187-1196.
  • Clark, B. (2019). Neuromuscular Changes with Aging and Sarcopenia.. 1. The Journal of frailty & aging; 8: 7-9.
  • Clark, B., Woods, A., Clark, L., Criss, C., Shadmehr, R., Grooms, D. (2019). The Aging Brain & the Dorsal Basal Ganglia: Implications for Age-Related Limitations of Mobility.. Advances in geriatric medicine and research; 1.
  • Clark, B., Russ, D., Nakazawa, M., France, C., Walkowski, S., Law, T., Applegate, M., Mahato, N., Lietkam, S., Odenthal, J., Corcos, D., Hain, S., Sindelar, B., Ploutz-Snyder, R., Thomas, J. (2018). A randomized control trial to determine the effectiveness and physiological effects of spinal manipulation and spinal mobilization compared to each other and a sham condition in patients with chronic low back pain: Study protocol for The RELIEF Study.. Contemporary clinical trials; 70: 41-52.
  • Sheth, K., Iyer, C., Wier, C., Crum, A., Bratasz, A., Kolb, S., Clark, B., Burghes AHM, ., Arnold, W. (2018). Muscle strength and size are associated with motor unit connectivity in aged mice.. Neurobiology of aging; 67: 128-136.
  • Consitt, L., Saxena, G., Slyvka, Y., Clark, B., Friedlander, M., Zhang, Y., Nowak, F. (2018). Paternal high-fat diet enhances offspring whole-body insulin sensitivity and skeletal muscle insulin signaling early in life.. 5. Physiological reports; 6.
  • Clark, B., Berger, J., Berul, C., Jonas, R., Kaltman, J., Lapsa, J., Nath, D., Sherwin, E., Sinha, P., Zurakowski, D., Moak, J. (2018). Risk Factors for Development of Ectopic Atrial Tachycardia in Post-operative Congenital Heart Disease.. 3. Pediatric cardiology; 39: 459-465.
  • Tieland, M., Trouwborst, I., Clark, B. (2018). Skeletal muscle performance and ageing.. 1. Journal of cachexia, sarcopenia and muscle; 9: 3-19.
  • Russ, D., Ross, A., Clark, B., Thomas, J. (2018). The Effects of Task Type on Time to Task Failure During Fatigue: A Modified Sørensen Test.. 1. Journal of motor behavior; 50: 96-103.
  • Consitt, L., Clark, B. (2018). The Vicious Cycle of Myostatin Signaling in Sarcopenic Obesity: Myostatin Role in Skeletal Muscle Growth, Insulin Signaling and Implications for Clinical Trials.. 1. The Journal of frailty & aging; 7: 21-27.
  • Mahato , N., Sybert, D., Law , T., Clark, B. (2017). Effects of Spine Loading in a Patient with Post-decompression Lumbar Disc Hemialtion: Quantifying Olisthesis, Intervertebral Mophology and Dural Canal Dimensions Using an Open Weight-bearing MRI.
  • Arnold, W., Clark, B. (2017). Is aging-related loss of physical function and muscle atrophy driven by motor neuron/unit loss?.
  • Loucks, A., Clark, B., Bowman, L. (2017). Response to "Clinical Evaluation of Bone Strength and Fracture Risk".. 4. Current osteoporosis reports; 15: 396-397.
  • Mahato, N., Montuelle, S., Goubeaux, C., Cotton, J., Williams, S., Thomas, J., Clark, B. (2017). Quantification of intervertebral displacement with a novel MRI-based modeling technique: Assessing measurement bias and reliability with a porcine spine model.. Magnetic resonance imaging; 38: 77-86.
  • Clark, B., Manini, T. (2017). Can KAATSU Exercise Cause Rhabdomyolysis?. 1. Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine; 27: e1-e2.
  • Mahato , N., Montuelle, S., Cotton, J., Williams, S., Thomas, J., Clark, B. (2016). Development of Morphology-based Modeling Technique for tracking solid-body displacements: Examining the Reliability of a Potential MRI-only approach for joint kinematics Assessment.
  • Manini, T., Clark, B. (2016). Results from a web-based survey to identify dynapenia screening tools and risk factors.
  • Clark, B., Sumihara, K., McCarter, R., Berul, C., Moak, J. (2016). Getting to zero: impact of electroanatomical mapping on fluoroscopy use in pediatric catheter ablation.. 2. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing; 46: 183-9.
  • Oki, K., Mahato, N., Nakazawa, M., Amano, S., France, C., Russ, D., Clark, B. (2016). Preliminary Evidence That Excitatory Transcranial Direct Current Stimulation Extends Time to Task Failure of a Sustained, Submaximal Muscular Contraction in Older Adults.. 8. The journals of gerontology. Series A, Biological sciences and medical sciences; 71: 1109-12.
  • Amano, S., Ludin, A., Clift, R., Nakazawa, M., Law, T., Rush, L., Manini, T., Thomas, J., Russ, D., Clark, B. (2016). Effectiveness of blood flow restricted exercise compared with standard exercise in patients with recurrent low back pain: study protocol for a randomized controlled trial.. Trials; 17: 81.
  • Law, T., Clark, L., Clark, B. (2016). Resistance Exercise to Prevent and Manage Sarcopenia and Dynapenia.. 1. Annual review of gerontology & geriatrics; 36: 205-228.
  • Gau , J., Nakazawa , M., Clark, B., Kao , T. (2015). Association between serum calcium level and fracture risk among hospitalized adults: a case control study.
  • Clark, B., Law, T., Hong , S. (2015). From Brain to Body: the impact of nervous system declines on muscle performance in aging.
  • Clark, B., Taylor, J., Hong, S., Law, T., Russ, D. (2015). Weaker Seniors Exhibit Motor Cortex Hypoexcitability and Impairments in Voluntary Activation.. 9. The journals of gerontology. Series A, Biological sciences and medical sciences; 70: 1112-9.
  • Oki, K., Law, T., Loucks, A., Clark, B. (2015). The effects of testosterone and insulin-like growth factor 1 on motor system form and function.. Experimental gerontology; 64: 81-6.
  • Shanbhag , R., Mahato , N., Clark, B., Choi , J. (2014). Medical Equipment to make Colonoscopy Procedures Safer for Physicians: Control head holder and splatter shield.
  • Clark, B., Mahato, N., Nakazawa, M., Law, T., Thomas, J. (2014). The power of the mind: the cortex as a critical determinant of muscle strength/weakness.. 12. Journal of neurophysiology; 112: 3219-26.
  • Clark, B., Blazyk, J. (2014). Research in the osteopathic medical profession: roadmap to recovery.. 8. The Journal of the American Osteopathic Association; 114: 608-14.
  • Williams, P., Hoffman, R., Clark, B. (2014). Cortical and spinal mechanisms of task failure of sustained submaximal fatiguing contractions.. 3. PloS one; 9: e93284.
  • Kaya, R., Hoffman, R., Clark, B. (2014). Reliability of a modified motor unit number index (MUNIX) technique.. 1. Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology; 24: 18-24.
  • Williams, P., Clark, B., Hoffman , R. (2013). Anodal Transcranial direct current stimulation enhances time to task failure of a sustained submaximal contraction.
  • Clark, B., LePorte, A., Clark , S., Hoffman, R., Quick , A., Wilson , T., Thomas, J. (2013). Characterization of Persistent Mal de Debarquement Syndrome: Effects on balance, psychological traits, and motor cortical excitability.
  • Mika, A., Clark, B., Oleksy, Ł. (2013). The influence of high and low heeled shoes on EMG timing characteristics of the lumbar and hip extensor complex during trunk forward flexion and return task.. 6. Manual therapy; 18: 506-11.
  • Kaya, R., Nakazawa, M., Hoffman, R., Clark, B. (2013). Interrelationship between muscle strength, motor units, and aging.. 9. Experimental gerontology; 48: 920-5.
  • Manini, T., Hong, S., Clark, B. (2013). Aging and muscle: a neuron's perspective.. 1. Current opinion in clinical nutrition and metabolic care; 16: 21-6.
  • Russ, D., Clark, B., Krause , J., Hagerman , F. (2012). Human Skeletal muscle adaptations to sprint-modeled electrical stimulation.
  • Manini, T., Yarrow, J., Buford, T., Clark, B., Conover, C., Borst, S. (2012). Growth hormone responses to acute resistance exercise with vascular restriction in young and old men.. 5. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 22: 167-72.
  • DA Goss, Jr, ., Thomas, J., Walkowski, S., Clark, S., Licciardone, J., Yue, G., Clark, B. (2012). Non-thrust manual therapy reduces erector spinae short-latency stretch reflex asymmetries in patients with chronic low back pain.. 5. Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology; 22: 663-9.
  • Russ, D., Clark, B., Krause, J., Hagerman, F. (2012). Development of a neuromuscular electrical stimulation protocol for sprint training.. 9. Medicine and science in sports and exercise; 44: 1810-9.
  • Clark, B., Thomas, J., Walkowski, S., Howell, J. (2012). The biology of manual therapies.. 9. The Journal of the American Osteopathic Association; 112: 617-29.
  • Tennant, K., Takacs, S., Gau, J., Clark, B., Russ, D. (2012). A preliminary study of symptomatic fatigue in rural older adults.. 4. Aging clinical and experimental research; 24: 324-30.
  • Macke, A., LePorte, A., Clark, B. (2012). Social, societal, and economic burden of mal de debarquement syndrome.. 7. Journal of neurology; 259: 1326-30.
  • Russ, D., Gregg-Cornell, K., Conaway, M., Clark, B. (2012). Evolving concepts on the age-related changes in "muscle quality".. 2. Journal of cachexia, sarcopenia and muscle; 3: 95-109.
  • Mika, A., Oleksy, L., Mika, P., Marchewka, A., Clark, B. (2012). The effect of walking in high- and low-heeled shoes on erector spinae activity and pelvis kinematics during gait.. 5. American journal of physical medicine & rehabilitation; 91: 425-34.
  • Clark, B., Manini, T. (2012). What is dynapenia?. 5. Nutrition (Burbank, Los Angeles County, Calif.); 28: 495-503.
  • Mika, A., Oleksy, Ł., Mika, P., Marchewka, A., Clark, B. (2012). The influence of heel height on lower extremity kinematics and leg muscle activity during gait in young and middle-aged women.. 4. Gait & posture; 35: 677-80.
  • Goss, D., Hoffman, R., Clark, B. (2012). Utilizing transcranial magnetic stimulation to study the human neuromuscular system.. 59. Journal of visualized experiments : JoVE.
  • Manini, T., Clark, B. (2012). Dynapenia and aging: an update.. 1. The journals of gerontology. Series A, Biological sciences and medical sciences; 67: 28-40.
  • Bender, R., Wilson, T., Hoffman , R., Clark, B. (2011). Effects of passive hyperthermia on muscle fatigue, central activation, and cortical excitability.
  • Clark, B. (2011). Hot topic issue of Current Aging Science titled 'Age-related changes in neuromuscular function and physiology': an introduction of perspectives.
  • Manini, T., Vincent , K., Leeuwenburgh, C., Lees, H., Kavazis , A., Borst , S., Clark, B. (2011). Myogenic and proteolytic mRNA expression following blood flow restricted exercise.
  • Goss, D., Thomas, J., Clark, B. (2011). Optimization and reliability of experimental techniques to assess cortical and stretch reflex excitability of the erector spinae muscles.
  • Clark, B., Taylor, J. (2011). Age-related changes in motor cortical properties and voluntary activation of skeletal muscle.. 3. Current aging science; 4: 192-9.
  • Clark, B., Manini, T., Hoffman, R., Williams, P., Guiler, M., Knutson, M., McGlynn, M., Kushnick, M. (2011). Relative safety of 4 weeks of blood flow-restricted resistance exercise in young, healthy adults.. 5. Scandinavian journal of medicine & science in sports; 21: 653-62.
  • Clark, B., DA Goss, Jr, ., Walkowski, S., Hoffman, R., Ross, A., Thomas, J. (2011). Neurophysiologic effects of spinal manipulation in patients with chronic low back pain.. BMC musculoskeletal disorders; 12: 170.
  • Thomas, J., Ross, A., Russ, D., Clark, B. (2011). Time to task failure of trunk extensor muscles differs with load type.. 1. Journal of motor behavior; 43: 27-9.
  • Clark, B., Taylor, J., Hoffman, R., Dearth, D., Thomas, J. (2010). Cast immobilization increases long-interval intracortical inhibition.. 3. Muscle & nerve; 42: 363-72.
  • McGinley, M., Hoffman, R., Russ, D., Thomas, J., Clark, B. (2010). Older adults exhibit more intracortical inhibition and less intracortical facilitation than young adults.. 9. Experimental gerontology; 45: 671-8.
  • Clark, B., Manini, T. (2010). Functional consequences of sarcopenia and dynapenia in the elderly.. 3. Current opinion in clinical nutrition and metabolic care; 13: 271-6.
  • Dearth, D., Umbel, J., Hoffman, R., Russ, D., Wilson, T., Clark, B. (2010). Men and women exhibit a similar time to task failure for a sustained, submaximal elbow extensor contraction.. 6. European journal of applied physiology; 108: 1089-98.
  • Clark, B., Manini, T. (2009). SARCOPENIA =/ DYNAPENIA.
  • Umbel, J., Hoffman, R., Dearth, D., Chleboun, G., Manini, T., Clark, B. (2009). Delayed-onset muscle soreness induced by low-load blood flow-restricted exercise.. 6. European journal of applied physiology; 107: 687-95.
  • Clark, B. (2009). In vivo alterations in skeletal muscle form and function after disuse atrophy.. 10. Medicine and science in sports and exercise; 41: 1869-75.
  • Clark, B., Walkowski, S., Conatser, R., Eland, D., Howell, J. (2009). Muscle functional magnetic resonance imaging and acute low back pain: a pilot study to characterize lumbar muscle activity asymmetries and examine the effects of osteopathic manipulative treatment.. Osteopathic medicine and primary care; 3: 7.
  • Manini, T., Clark, B. (2009). Blood flow restricted exercise and skeletal muscle health.. 2. Exercise and sport sciences reviews; 37: 78-85.
  • Clark, B., Manini, T., Hoffman, R., Russ, D. (2009). Restoration of voluntary muscle strength after 3 weeks of cast immobilization is suppressed in women compared with men.. 1. Archives of physical medicine and rehabilitation; 90: 178-80.
  • Clark, B. (1988). Primeval procreative comet pond.. 3. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life; 18: 209-38.

Book, Chapter in Scholarly Book (1)

  • Wages , N., Clark, B., Criss , C., Grooms , D. (2019). Neural Principles of Human Movement. .

Conference Proceeding (1)

  • Clark, B., Yakushin, S., Dai, M., Zink, R., Liu, C. (2019). The Design of a Virtual Reality App for Mal de Debarquement Syndrome. 110--114.

Other (2)

  • Yue, G., Clark, B., Li , S., Vaillancourt, D. (2017). Understanding Neuromuscular System Plasticity to Improve Motor Function in Health, Disease, and Injury.. Neural plasticity; 2017: 2425180.
  • Clark, B., Quick, A. (2011). Exploring the pathophysiology of mal de debarquement.. 6. Journal of neurology; 258: 1166-8.