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Fabian Benencia

Fabian Benencia
Associate Professor, Immunology
Academic & Research Center 202C
Biomedical Engineering

Research Interests: immunity responses in diseases, diabetes, obesity

Journal Article, Academic Journal (38)

  • Ghadieh, H., Abu Helal, R., Muturi, H., Issa, D., Russo, L., Abdallah, S., Najjar, J., Benencia, F., Vazquez, G., Li , W., Najjar, S. (2020). Loss of Hepatic Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Links Nonalcoholic Steatohepatitis to Atherosclerosis.. 11. Hepatology communications; 4: 1591-1609.
  • Young, J., Henry, B., Benencia, F., Bell, S., List, E., Kopchick, J., Berryman, D. (2020). GHR-/- Mice are protected from obesity-related white adipose tissue inflammation.. Journal of neuroendocrinology; e12854.
  • Phillippi, B., Singh, M., Loftus, T., Smith, H., Muccioli, M., Wright, J., Pate, M., Benencia, F. (2020). Effect of laminin environments and tumor factors on the biology of myeloid dendritic cells.. 1. Immunobiology; 225: 151854.
  • McCall, K., Muccioli, M., Benencia, F. (2020). Toll-Like Receptors Signaling in the Tumor Microenvironment.. Advances in experimental medicine and biology; 1223: 81-97.
  • Dangaj, D., Bruand, M., Grimm, A., Ronet, C., Barras, D., Duttagupta, P., Lanitis, E., Duraiswamy, J., Tanyi, J., Benencia, F., Conejo-Garcia, J., Ramay, H., Montone, K., Powell, Jr, D., Gimotty, P., Facciabene, A., Jackson, D., Weber, J., Rodig, S., Hodi, S., Kandalaft, L., Irving, M., Zhang, L., Foukas, P., Rusakiewicz, S., Delorenzi, M., Coukos, G. (2019). Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.. 6. Cancer cell; 35: 885-900.e10.
  • Singh, M., Benencia, F. (2019). Inflammatory processes in obesity: focus on endothelial dysfunction and the role of adipokines as inflammatory mediators.. 4. International reviews of immunology; 38: 157-171.
  • Muccioli, M., Nandigam, H., Loftus, T., Singh, M., Venkatesh, A., Wright, J., Pate, M., McCall, K., Benencia, F. (2018). Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues.. 94. Oncotarget; 9: 36666-36683.
  • Sprague, L., Braidwood, L., Conner, J., Cassady, K., Benencia, F., Cripe, T. (2018). Please stand by: how oncolytic viruses impact bystander cells.. 9. Future virology; 13: 671-680.
  • Venkatesh, A., Nandigam, H., Muccioli, M., Singh, M., Loftus, T., Lewis, D., Pate, M., Benencia, F. (2018). Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells.. 6-7. Immunobiology; 223: 466-476.
  • Woody, A., Figueroa, W., Benencia, F., Zoccola, P. (2017). Stress-Induced Parasympathetic Control and Its Association With Inflammatory Reactivity.. 3. Psychosomatic medicine; 79: 306-310.
  • Singh, M., Loftus, T., Webb, E., Benencia, F. (2016). Minireview: Regulatory T Cells and Ovarian Cancer.. 8. Immunological investigations; 45: 712-720.
  • Woody, A., Figueroa, W., Benencia, F., Zoccola, P. (2016). Trait reflection predicts interleukin-6 response to a social-evaluative stressor.. Brain, behavior, and immunity; 52: 27-31.
  • Casey, S., Amedei, A., Aquilano, K., Azmi, A., Benencia, F., Bhakta, D., Bilsland, A., Boosani, C., Chen, S., Ciriolo, M., Crawford, S., Fujii, H., Georgakilas, A., Guha, G., Halicka, D., Helferich, W., Heneberg, P., Honoki, K., Keith, W., Kerkar, S., Mohammed, S., Niccolai, E., Nowsheen, S., Vasantha Rupasinghe, H., Samadi, A., Singh, N., Talib, W., Venkateswaran, V., Whelan, R., Yang, X., Felsher, D. (2015). Cancer prevention and therapy through the modulation of the tumor microenvironment.. Seminars in cancer biology; 35 Suppl: S199-S223.
  • Block, K., Gyllenhaal, C., Lowe, L., Amedei, A., Amin ARMR, ., Amin, A., Aquilano, K., Arbiser, J., Arreola, A., Arzumanyan, A., Ashraf, S., Azmi, A., Benencia, F., Bhakta, D., Bilsland, A., Bishayee, A., Blain, S., Block, P., Boosani, C., Carey, T., Carnero, A., Carotenuto, M., Casey, S., Chakrabarti, M., Chaturvedi, R., Chen, G., Chen, H., Chen, S., Chen, Y., Choi, B., Ciriolo, M., Coley, H., Collins, A., Connell, M., Crawford, S., Curran, C., Dabrosin, C., Damia, G., Dasgupta, S., DeBerardinis, R., Decker, W., Dhawan, P., Diehl AME, ., Dong, J., Dou, Q., Drew, J., Elkord, E., El-Rayes, B., Feitelson, M., Felsher, D., Ferguson, L., Fimognari, C., Firestone, G., Frezza, C., Fujii, H., Fuster, M., Generali, D., Georgakilas, A., Gieseler, F., Gilbertson, M., Green, M., Grue, B., Guha, G., Halicka, D., Helferich, W., Heneberg, P., Hentosh, P., Hirschey, M., Hofseth, L., Holcombe, R., Honoki, K., Hsu, H., Huang, G., Jensen, L., Jiang, W., Jones, L., Karpowicz, P., Keith, W., Kerkar, S., Khan, G., Khatami, M., Ko, Y., Kucuk, O., Kulathinal, R., Kumar, N., Kwon, B., Le , A., Lea, M., Lee, H., Lichtor, T., Lin, L., Locasale, J., Lokeshwar, B., Longo, V., Lyssiotis, C., MacKenzie, K., Malhotra, M., Marino, M., Martinez-Chantar, M., Matheu, A., Maxwell, C., McDonnell, E., Meeker, A., Mehrmohamadi, M., Mehta, K., Michelotti, G., Mohammad, R., Mohammed, S., Morre, D., Muralidhar, V., Muqbil, I., Murphy, M., Nagaraju, G., Nahta, R., Niccolai, E., Nowsheen, S., Panis, C., Pantano, F., Parslow, V., Pawelec, G., Pedersen, P., Poore, B., Poudyal, D., Prakash, S., Prince, M., Raffaghello, L., Rathmell, J., Rathmell, W., Ray, S., Reichrath, J., Rezazadeh, S., Ribatti, D., Ricciardiello, L., Robey, R., Rodier, F., Rupasinghe HPV, ., Russo, G., Ryan, E., Samadi, A., Sanchez-Garcia, I., Sanders, A., Santini, D., Sarkar, M., Sasada, T., Saxena, N., Shackelford, R., Shantha Kumara HMC, ., Sharma, D., Shin, D., Sidransky, D., Siegelin, M., Signori, E., Singh, N., Sivanand, S., Sliva, D., Smythe, C., Spagnuolo, C., Stafforini, D., Stagg, J., Subbarayan, P., Sundin, T., Talib, W., Thompson, S., Tran, P., Ungefroren, H., Vander Heiden, M., Venkateswaran, V., Vinay, D., Vlachostergios, P., Wang, Z., Wellen, K., Whelan, R., Yang, E., Yang, H., Yang, X., Yaswen, P., Yedjou, C., Yin, X., Zhu, J., Zollo, M. (2015). Designing a broad-spectrum integrative approach for cancer prevention and treatment.. Seminars in cancer biology; 35 Suppl: S276-S304.
  • Olarescu, N., Berryman, D., Householder, L., Lubbers, E., List, E., Benencia, F., Kopchick, J., Bollerslev, J. (2015). GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells.. 1. The Journal of endocrinology; 226: 13-23.
  • Benencia, F., Harshman, S., Duran-Ortiz, S., Lubbers, E., List, E., Householder, L., Al-Naeeli, M., Liang, X., Welch, L., Kopchick, J., Berryman, D. (2015). Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations.. 5. Endocrinology; 156: 1794-803.
  • McCall, K., Thuma, J., Courreges, M., Benencia, F., James, C., Malgor, R., Kantake, N., Mudd, W., Denlinger, N., Nolan, B., Wen, L., Schwartz, F. (2015). Toll-like receptor 3 is critical for coxsackievirus B4-induced type 1 diabetes in female NOD mice.. 2. Endocrinology; 156: 453-61.
  • Shirure, V., Liu, T., Delgadillo, L., Cuckler, C., Tees, D., Benencia, F., Goetz, D., Burdick, M. (2015). CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions. 1. American Journal of Physiology-Cell Physiology; 308: C68-78.
  • Zoccola, P., Figueroa, W., Rabideau, E., Woody, A., Benencia, F. (2014). Differential effects of poststressor rumination and distraction on cortisol and C-reactive protein.. 12. Health psychology : official journal of the Division of Health Psychology, American Psychological Association; 33: 1606-9.
  • Muccioli, M., Benencia, F. (2014). Toll-like Receptors in Ovarian Cancer as Targets for Immunotherapies.. Frontiers in immunology; 5: 341.
  • Motz, G., Santoro, S., Wang, L., Garrabrant, T., Lastra, R., Hagemann, I., Lal, P., Feldman, M., Benencia, F., Coukos, G. (2014). Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.. 6. Nature medicine; 20: 607-15.
  • Benencia, F., Muccioli, M., Alnaeeli, M. (2014). Perspectives on reprograming cancer-associated dendritic cells for anti-tumor therapies.. Frontiers in oncology; 4: 72.
  • Walkowski, S., Singh, M., Puertas, J., Pate, M., Goodrum, K., Benencia, F. (2014). Osteopathic manipulative therapy induces early plasma cytokine release and mobilization of a population of blood dendritic cells.. 3. PloS one; 9: e90132.
  • Caballero-Campo, P., Buffone, M., Benencia, F., Conejo-GarcĂ­a, J., Rinaudo, P., Gerton, G. (2014). A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.. 1. Journal of cellular physiology; 229: 68-78.
  • McCall, K., Schmerr, M., Thuma, J., James, C., Courreges, M., Benencia, F., Malgor, R., Schwartz, F. (2013). Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice.. 4. Molecules (Basel, Switzerland); 18: 3841-58.
  • Osterbur, J., Sprague, L., Muccioli, M., Pate, M., Mansfield, K., McGinty, J., Li , Y., Li , Y., Shirure, V., Courreges, M., Benencia, F. (2013). Adhesion to substrates induces dendritic cell endothelization and decreases immunological response.. 1. Immunobiology; 218: 64-75.
  • Burdick, M., Henson, K., Delgadillo, L., Choi, Y., Goetz, D., Tees, D., Benencia, F. (2012). Expression of E-selectin ligands on circulating tumor cells: Cross-regulation with cancer stem cell regulatory pathways?. Frontiers In Oncology; 2: 103 (11 pages).
  • Muccioli, M., Longstaff, C., Benencia, F. (2012). Absence of CD4 T-cell help provides a robust CD8 T-cell response while inducing effective memory in a preclinical model of melanoma.. 5. Immunotherapy; 4: 477-81.
  • Benencia, F., Sprague, L., McGinty, J., Pate, M., Muccioli, M. (2012). Dendritic cells the tumor microenvironment and the challenges for an effective antitumor vaccination.. Journal of biomedicine & biotechnology; 2012: 425476.
  • Muccioli, M., Sprague, L., Nandigam, H., Pate, M., Benencia, F. (2012). Toll-like receptors as novel therapeutic targets for ovarian cancer.. ISRN oncology; 2012: 642141.
  • Sprague, L., Muccioli, M., Pate, M., Meles, E., McGinty, J., Nandigam, H., Venkatesh, A., Gu, M., Mansfield, K., Rutowski, A., Omosebi, O., Courreges, M., Benencia, F. (2011). The interplay between surfaces and soluble factors define the immunologic and angiogenic properties of myeloid dendritic cells.. BMC immunology; 12: 35.
  • Muccioli, M., Pate, M., Omosebi, O., Benencia, F. (2011). Generation and labeling of murine bone marrow-derived dendritic cells with Qdot nanocrystals for tracking studies.. 52. Journal of visualized experiments : JoVE.
  • Alagkiozidis, I., Facciabene, A., Tsiatas, M., Carpenito, C., Benencia, F., Adams, S., Jonak, Z., June, C., Powell, Jr, D., Coukos, G. (2011). Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy.. Journal of translational medicine; 9: 77.
  • Chiang, C., Benencia, F., Coukos, G. (2010). Whole tumor antigen vaccines.. 3. Seminars in immunology; 22: 132-43.
  • Franco, L., Feledi, C., Massouh, E., Benencia, F. (2010). Aminoguanidine administered during the induction of oral tolerance alters the systemic response of the tolerised rats.. 1. Cellular immunology; 261: 42-50.
  • Alagkiozidis, I., Facciabene, A., Carpenito, C., Benencia, F., Jonak, Z., Adams, S., Carroll, R., Gimotty, P., Hammond, R., Danet-Desnoyers, G., June, C., Powell, Jr, D., Coukos, G. (2009). Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin and IL-18.. Journal of translational medicine; 7: 104.
  • Christian, N., Benencia, F., Milone, M., Li , G., Frail, P., Therien, M., Coukos, G., Hammer, D. (2009). In vivo dendritic cell tracking using fluorescence lifetime imaging and near-infrared-emissive polymersomes.. 3. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging; 11: 167-77.
  • Christman, 2nd, M., Goetz, D., Dickerson, E., McCall, K., Lewis, C., Benencia, F., Silver, M., Kohn, L., Malgor, R. (2008). Wnt5a is expressed in murine and human atherosclerotic lesions.. 6. American journal of physiology. Heart and circulatory physiology; 294: H2864-70.

Book, Chapter in Scholarly Book (4)

  • Benencia, F. (2014). Antigen-specific mRNA transfection of autologous dendritic cells. Methods in Molecular Biology. Springer, NY: Humana Press; 77-86.
  • McCall, K., Benencia, F., Kohn, L., Malgor, R., Schwartz, A., Schwartz, F. (2012). Toll-Like Receptors as Novel Therapeutic Targets for the Treatment of Pancreatic Cancer. Open Access Publisher.
  • McCall, K., Benencia, F., Kohn, L., Malgor, R., Schwartz, A., Schwartz, F. (2012). Toll-like Receptors as Novel Therapeutic Targets for the Treatment of Pancreatic Cancer. Sanjay Srivastava.
  • Coukos, G., Benencia, F. (2009). Dendritic cells: From inducers of specific T-cell responses to promoters of angiogenesis. Berlin: Springer-Verlag; 231-243.

Other (1)

  • Adams, S., Benencia, F. (2015). Immunotherapy for ovarian cancer: what are the targets of the future?. 9. Future oncology (London, England); 11: 1293-6.

Review (2)

  • Singh, M., Benencia, F. (2015). Minireview: Optimization of Human Dendritic Cells for Antitumor Vaccination.
  • Benencia, F. (2013). RNA vaccines for anti-tumor therapy.