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Studying mammalian neurovascular development, physiology and pathophysiology

The Nielsen Lab

About the Nielsen Laboratory

Lab research interests include genetic regulation of mammalian neurovascular development, physiology and pathophysiology.

Interdependent development and functions of the mammalian nervous and vascular systems are tightly coordinated. The brain vasculature provides a critical and expansive blood supply to support neuronal metabolism and function, and vascular lesions within the brain are often accompanied by neurological dysfunction. Our lab is interested in understanding how these systems influence one another – e.g., how diverse neural and vascular cell populations respond to cues from one another. The lab currently studies neurovascular regulation in the context of brain arteriovenous malformation (AVM), a human vascular disease characterized by direct delivery of blood from artery to vein (without intervening capillaries), vessel entanglements, and often accompanied by neurological deficit. We are using genetic models of brain AVM to determine molecular and cellular mechanisms that regulate neurovascular development and function – and mechanisms involved in neurovascular pathogenesis – using mouse genetics, molecular and cell biological, and imaging approaches.

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Recent News:

Biological Sciences Ph.D. candidate Subhodip Adhicary defends his dissertation, April 6

5 months 1 week ago

Subhodip Adhicary, portraitFrom the Ohio University Calendar Ph.D Candidate Subhodip Adhicary defends his dissertation, “Impairment in postnatal cerebrovascular remodeling mediated by small GTPases in endothelial Rbpj deficient Brain Arteriovenous Malformation,” on Wednesday, April 6, at 1:30 p.m. His adviser is Dr. Corinne Nielsen, assistant professor of Biological Sciences in the College of […]

The post Biological Sciences Ph.D. candidate Subhodip Adhicary defends his dissertation, April 6 appeared first on Ohio University | College of Arts & Sciences.

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Six HTC Biological Sciences + Neuroscience Seniors Present their Theses in April

1 year 3 months ago

The Ohio University sundialSix Honors Tutorial College biological sciences and neuroscience seniors are presenting their theses this spring in the Biological Sciences Department. To watch the presentation via Teams, contact Dr. Soichi Tanda at tanda@ohio.edu. Hailee Sorensen presents on April 14 at 2 p.m. Title: Investigating the Role of the RNA Chaperone Protein […]

The post Six HTC Biological Sciences + Neuroscience Seniors Present their Theses in April appeared first on Ohio University | College of Arts & Sciences.

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Nielsen Recognized as Honors Tutorial College Distinguished Mentor

3 years 2 months ago

From left, Dr. Corinne Nielsen and Samantha SelhorstWhen the Honors Tutorial College recognized outstanding mentorship at its May 3 graduate reception, one of four Distinguished Mentor awards went to Dr. Corinne Nielsen, Assistant Professor of Biological Sciences. Nielsen was nominated by Samantha Selhorst, a graduating HTC Neurosciences student, who completed senior thesis research in Nielsen’s lab. See […]

The post Nielsen Recognized as Honors Tutorial College Distinguished Mentor appeared first on Ohio University | College of Arts & Sciences.

Bob Colvin