Helpful Links

Navigate OHIO

Connect With Us

Ohio University
1 Ohio University
Athens OH 45701
Directions
Contact Ohio University
College of Arts and Sciences
Heritage College of Osteopathic Medicine
Russ College of Engineering and Technology
Faculty
Ohio Expert
mccall
Ohio Expert

Kelly McCall

Professor, Associate Chair
Athens Campus
Biomedical Engineering
Diabetes Institute
Molecular and Cellular Biology
Specialty Medicine
740.593.0926
Academic and Research Center

Education

  • Molecular & Cellular Biology (PhD), Ohio University, 2003
  • Biological Sciences (BS), Ohio University, 1997

Areas of Expertise

  • Atherosclerosis
  • Autoimmune diseases
  • Autoimmunity
  • Cancer
  • Chronic inflammation
  • Chronic inflammatory diseases
  • Diabetes mellitus, Type 1 and 2
  • Interferon regulatory factor-3
  • Mouse models of disease
  • Novel therapeutics
  • Nonalcoholic fatty liver disease
  • Obesity
  • Phenylmethimazole (C10)
  • Toll-like receptors
  • Wnt5a
OHIO Expert

The Ohio University Experts Directory is a searchable listing of faculty members who are knowledgeable in specific topical areas. These experts have provided their contact information and this directory serves to provide a way to learn about the broad range of expertise at Ohio University and also to connect with an expert about any particular topic of interest.

View Expert Directory

Biography

I study molecular pathways involved in autoimmune/inflammatory diseases (AIDs) & utilize this knowledge to develop novel therapeutics. My work established aberrant toll-like receptor (TLR) expression & signaling in non-immune cells is a key mediator of AIDs; work that initiated a paradigm shift.

ResearchGate
National Center for Biotechnology Information (NCBI)

Journal Article, Academic Journal (35)

  • Mehrani, R., Mondal, J., Ghazanfari, D., Goetz, D., McCall, K., Bergmeier, S., Sharma, S. (2024). Capturing the Effects of Single Atom Substitutions on the Inhibition Efficiency of Glycogen Synthase Kinase-3β Inhibitors via Markov State Modeling and Experiments. 14. J Chem Theory Comput; 20: 6278-6286.
  • McCall, K., Walter, D., Patton, A., Thuma, J., Courreges de Benencia, M., Palczewski, G., Goetz, D., Bergmeier, S., Schwartz, F. (2023). Anti-Inflammatory and Therapeutic Effects of a Novel Small-Molecule Inhibitor of Inflammation in a Male C57BL/6J Mouse Model of Obesity-Induced NAFLD/MAFLD. 16. Journal of Inflammation Research; 2023: 5339-5366.
  • Ghazanfari, D., Courreges de Benencia, M., Belinski, L., Lloyd, J., Bergmeier, S., McCall, K., Goetz, D. (2022). Mechanistic Insights into SARS-CoV-2 Spike Protein Induction of the Chemokine CXCL10. Submitted.
  • Benner, S., Walter, D., Thuma, J., Courreges, M., James, C., Schwartz, F., McCall, K. (2022). TLR3 is Critical to the Pancreatic Islet Minieu Required for CVB4-Induced Type 1 Diabetes in Female NOD Mice. Pancreas.
  • Ghazanfari, D., Courreges, M., Belinski, L., Bergmeier, S., McCall, K., Goetz, D. (2022). Evidence for investigating GSK-3 inhibitors as potential therapeutics for severe COVID-19. Biochemical and Biophysical Research Communications; 605: 171-176.
  • Walter, D., Thuma, J., Malgor, R., Schwartz, F., McCall, K., Coschigano, K. (2021). Consequences of Both Coxsackievirus B4 and Type 1 Diabetes on Female Non-Obese Diabetic Mouse Kidneys.. 11. Microorganisms; 9.
  • Ghazanfari, D., Noori, M., Bergmeier, S., Hines, J., McCall, K., Goetz, D. (2021). A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism.. Bioorganic & medicinal chemistry; 40: 116179.
  • Kauffman, M., Allen, A., Reynolds, N., Ghazanfari, D., Nazemidashtarjandi, S., Faik, A., Burdick, M., McCall, K., Goetz, D. (2020). Evidence that Knock Down of GSK-3b in Haploid Chronic Myelogenous Leukemia Cells Augments IFN-g Induced Apoptosis and Necrosis. Leukemia Research.
  • Kauffman, M., Nazemidashtarjandi, S., Ghazanfari, D., Allen, A., Reynolds, N., Faik, A., Burdick, M., McCall, K., Goetz, D. (2020). Evidence that knock down of GSK-3β in Chronic Myelogenous Leukemia cells augments IFN-γ-induced apoptosis.. Leukemia Research; 99: 106464.
  • Noori, M., Courreges, M., Bergmeier, S., McCall, K., Goetz, D. (2020). Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor.. European Journal of Pharmacology; 883: 173340.
  • Walter, D., Benner, S., Oaks, R., Thuma, J., Malgor, R., Schwartz, F., Coschigano, K., McCall, K. (2020). Coxsackievirus B4 Exposure Results in Variable Pattern Recognition Response in the Kidneys of Female Non-obese Diabetic Mice Before Establishment of Diabetes.. Viral immunology.
  • McCall, K., Muccioli, M., Benencia, F. (2020). Toll-Like Receptors Signaling in the Tumor Microenvironment.. Advances in experimental medicine and biology; 1223: 81-97.
  • Noori, M., Bhatt, P., Courreges, M., Ghazanfari, D., Cuckler, C., Orac, C., McMills, M., Schwartz, F., Deosarkar, S., Bergmeier, S., McCall, K., Goetz, D. (2019). Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3. Am J Physiol - Cell Physiol; 317: C1289-C1303.
  • Muccioli, M., Nandigam, H., Loftus, T., Singh, M., Venkatesh, A., Wright, J., Pate, M., McCall, K., Benencia, F. (2018). Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues.. 94. Oncotarget; 9: 36666-36683.
  • Patton, A., Church, T., Wilson, C., Thuma, J., Goetz, D., Berryman, D., List, E., Schwartz, F., McCall, K. (2018). Phenylmethimazole abrogates diet-induced inflammation, glucose intolerance and NAFLD.. 3. The Journal of endocrinology; 237: 337-351.
  • Noori, M., O'Brien, J., Champa, Z., Deosarkar, S., Lanier, O., Qi, C., Burdick, M., Schwartz, F., Bergmeier, S., McCall, K., Goetz, D. (2017). Phenylmethimazole and a Thiazole Derivative of Phenylmethimazole Inhibit IL-6 Expression by Triple Negative Breast Cancer Cells. European Journal of Pharmacology; 803: 130-137. https://www.sciencedirect.com/science/article/pii/S0014299917302182?via%3Dihub.
  • Schwartz, A., Dickerson, E., Dagia, N., Malgor, R., McCall, K. (2016). TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration.. 69. Oncotarget; 8: 113295-113302.
  • Szulawski, R., Nakazawa, M., McCall, K., James, C., Schwartz, F. (2016). Laser capture microdissection tailored to type 1 diabetes mellitus research.. 6. BioTechniques; 60: 293-8.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple Modifications to Methimazole that Enhance its Inhibitory Effect on Tumor Necrosis Factor-alpha-Induced Vascular Cell Adhesion Molecule-1 Expression by Human Endothelial Cells. European Journal of Pharmacology; 751: 59-66.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple modifications to methimazole that enhance its inhibitory effect on tumor necrosis factor-α-induced vascular cell adhesion molecule-1 expression by human endothelial cells.. European journal of pharmacology; 751: 59-66.
  • McCall, K., Thuma, J., Courreges, M., Benencia, F., James, C., Malgor, R., Kantake, N., Mudd, W., Denlinger, N., Nolan, B., Wen, L., Schwartz, F. (2015). Toll-like receptor 3 is critical for coxsackievirus B4-induced type 1 diabetes in female NOD mice.. 2. Endocrinology; 156: 453-61.
  • Guo, A., Daniels, N., Thuma, J., McCall, K., Malgor, R., Schwartz, F. (2015). Diet is critical for prolonged glycemic control after short-term insulin treatment in high-fat diet-induced type 2 diabetic male mice.. 1. PloS one; 10: e0117556.
  • Deosarkar, S., Bhatt, P., Gillespie, J., Goetz, D., McCall, K. (2014). Inhibition of LPS-induced TLR4 signaling products in murine macrophages by phenylmethimazole: an assay methodology for screening potential phenylmethimazole analogs.. 8. Drug development research; 75: 497-509.
  • Malgor, R., Bhatt, P., Connolly, B., Jacoby, D., Feldmann, K., Silver, M., Nakazawa, M., McCall, K., Goetz, D. (2014). Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions.. 4. Inflammation research : official journal of the European Histamine Research Society ... [et al.]; 63: 277-85.
  • Slyvka, Y., Nowak, F., Wooten, M., McCall, K., Malgor, R., Wood, A., Inman, S. (2013). Urate Transporter 1 Protein Levels and Localization in Type 2 Diabetic and Non-Diabetic Zucker Rat Kidneys. 1. 3: 63-68.
  • McCall, K., Schmerr, M., Thuma, J., James, C., Courreges, M., Benencia, F., Malgor, R., Schwartz, F. (2013). Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice.. 4. Molecules (Basel, Switzerland); 18: 3841-58.
  • Courreges, M., Kantake, N., Goetz, D., Schwartz, F., McCall, K. (2012). Phenylmethimazole blocks dsRNA-induced IRF3 nuclear translocation and homodimerization.. 10. Molecules (Basel, Switzerland); 17: 12365-77.
  • Benavides, U., Gonzalez-Murguiondo, M., Harii, N., Lewis, C., Schwartz, A., Giuliani, C., Napolitano, G., Dagia, N., Malgor, R., McCall, K., Kohn, L. (2012). Phenylmethimazole inhibits production of proinflammatory mediators and is protective in an experimental model of endotoxic shock*.. 3. Critical care medicine; 40: 886-94.
  • Bhatt, P., Lewis, C., House, D., Keller, C., Kohn, L., Silver, M., McCall, K., Goetz, D., Malgor, R. (2012). Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions, and Oxidized LDL Treated Human Monocyte-Derived Macrophages.. The open circulation & vascular journal; 5: 1-7.
  • McCall, K., Holliday, D., Dickerson, E., Wallace, B., Schwartz, A., Schwartz, C., Lewis, C., Kohn, L., Schwartz, F. (2010). Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages.. 3. The Journal of endocrinology; 207: 343-53.
  • Kummitha, C., Mayle, K., Christman, 2nd, M., Deosarkar, S., Schwartz, A., McCall, K., Kohn, L., Malgor, R., Goetz, D. (2010). A sandwich ELISA for the detection of Wnt5a.. 1-2. Journal of immunological methods; 352: 38-44.
  • Schwartz, A., Malgor, R., Dickerson, E., Weeraratna, A., Slominski, A., Wortsman, J., Harii, N., Kohn, A., Moon, R., Schwartz, F., Goetz, D., Kohn, L., McCall, K. (2009). Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration.. 12. Clinical cancer research : an official journal of the American Association for Cancer Research; 15: 4114-22.
  • Christman, 2nd, M., Goetz, D., Dickerson, E., McCall, K., Lewis, C., Benencia, F., Silver, M., Kohn, L., Malgor, R. (2008). Wnt5a is expressed in murine and human atherosclerotic lesions.. 6. American journal of physiology. Heart and circulatory physiology; 294: H2864-70.
  • McCall, K., Harii, N., Lewis, C., Malgor, R., Kim, W., Saji, M., Kohn, A., Moon, R., Kohn, L. (2007). High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration.. 9. Endocrinology; 148: 4226-37.
  • Kim, W., Lewis, C., McCall, K., Malgor, R., Kohn, A., Moon, R., Kohn, L. (2007). Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms.. 1. The Journal of endocrinology; 193: 93-106.

Book, Chapter in Scholarly Book (1)

  • McCall, K., Benencia, F., Kohn, L., Malgor, R., Schwartz, A., Schwartz, F. (2012). Toll-like Receptors as Novel Therapeutic Targets for the Treatment of Pancreatic Cancer. Sanjay Srivastava.