Jonathan Young

Research

Growth hormone (GH) has diverse metabolic functions in addition to promoting growth. My research involves the relationship between GH and adipose tissue as well as GH and the intestine. The adipose portion of my research is focused on GH’s effects on the transcriptome of subcutaneous and visceral adipose depots across species and throughout the spectrum of GH action. The intestinal portion of my research centers around the effects of GH alterations on the gut microbiome and gut morphology.

Selected Publications

Young, J. A., Henry, B. E., Benencia, F., Bell, S., List, E. O., Kopchick, J. J., & Berryman, D. E. (2020). GHR −/− Mice are protected from obesity‐related white adipose tissue inflammation. Journal of Neuroendocrinology. https://doi.org/10.1111/jne.12854

Young, J. A., Jensen, E. A., Stevens, A., Duran-Ortiz, S., List, E. O., Berryman, D. E., & Kopchick, J. J. (2019). Characterization of an intestine-specific GH receptor knockout (IntGHRKO)mouse. Growth Hormone and IGF Research, 46–47, 5–15. https://doi.org/10.1016/j.ghir.2019.05.001

Young, J. A., List, E. O., & Kopchick, J. J. (2016). Deconstructing the Growth Hormone Receptor(GHR): Physical and Metabolic Phenotypes of Tissue-Specific GHR Gene-Disrupted Mice. In F. F. Casanueva (Ed.), Progress in Molecular Biology and Translational Science (Vol. 138, pp. 27–39). Academic Press. https://doi.org/10.1016/bs.pmbts.2015.10.014

Duran‐Ortiz, S., Young, J. A., Jara, A., Jensen, E. A., Basu, R., List, E. O., Qian, Y., Kopchick, J. J., & Berryman, D. E. (2020). Differential gene signature in adipose tissue depots of growth hormone transgenic mice. Journal of Neuroendocrinology. https://doi.org/10.1111/jne.12893

Jensen, E. A., Young, J. A., Jackson, Z., Busken, J., List, E. O., Carroll, R. K., Kopchick, J. J., Murphy, E. R., & Berryman, D. E. (2020). Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice. Endocrinology, 161(4). https://doi.org/10.1210/endocr/bqaa026

Soendergaard, C., Young, J., & Kopchick, J. (2017). Growth Hormone Resistance—Special Focus on Inflammatory Bowel Disease. International Journal of Molecular Sciences, 18(5), 1019. https://doi.org/10.3390/ijms18051019

Troike, K. M., Henry, B. E., Jensen, E. A., Young, J. A., List, E. O., Kopchick, J. J., & Berryman, D. E. (2017). Impact of Growth Hormone on Regulation of Adipose Tissue. In Comprehensive Physiology (Vol. 7, Issue 3, pp. 819–840). John Wiley & Sons, Inc. https://doi.org/10.1002/cphy.c160027