Human Subjects (IRB)

The IRB has been charged with reviewing and monitoring human subjects' research conducted under the auspices of Ohio University. Human subjects research is any project that meets both the federal definitions of "research" and "human subjects." Human subjects research conducted by Ohio University faculty, staff, or students is subject to IRB review or, when appropriate, a determination by the Office of Research Compliance that the research meets the criteria for an exempt category.  

For projects that meet the definition of human subjects research, you must receive an IRB approval or exempt determination before you may begin your research activities.  

Research is defined as a systematic investigation, including research development, testing, and evaluation, designed to develop or contribute to generalizable knowledge.  

Human subject is defined as a living individual about whom an investigator conducting research: 

(i) Obtains information or biospecimens through intervention or interaction with the individual, and uses, studies, or analyzes the information or biospecimens; or 

(ii) Obtains, uses, studies, analyzes, or generates identifiable private information or identifiable biospecimens. 

To submit for IRB review or an exempt determination, please make a new study submission in Cayuse 

If you need additional guidance, please contact us at 

All researchers who conduct human subjects research must complete the required training  

Cayuse Training Sessions

As of February 15, 2024, Cayuse is available for OHIO researchers to submit new IRB protocols. New study protocols are no longer being accepted in LEO. If you'd like to schedule a virtual Cayuse overview session for your department or college, please contact the Office of Research Compliance at

For more information about Cayuse Human Ethics, including frequently asked questions, please visit our Cayuse Human Ethics webpage

View a recording of a Cayuse Informational Session for Researchers. (You will need to log in with your OHIO credentials to view.)

LEO Training Sessions

Pre-recorded training videos are available to assist you in navigating LEO. These three videos are Navigating the IRB Process, Website Overview, and LEO Demonstration. They are intended to help faculty, staff, and students with questions they may have about the IRB review process at Ohio University and the LEO IRB submission system. The videos are available at this link:

If you have questions or need assistance after viewing the videos, please contact the Office of Research Compliance at


Need help? For more information on research involving human subjects, email or call 740-593-0664.