175 Clippinger Laboratories
|Course Name||Quarter Offered|
|Chem 241: Quantitative Analysis||Fall|
|Chem 728: Separations||Winter|
|Chem 487A: Forensic Chemistry||Spring|
Our research interests are in the understanding, development and application of mass spectrometric instrumentation. As well as gaining fundamental knowledge, these studies aim to extend the capabilities of mass spectrometry to various applications in areas such as proteomics, forensics, environmental monitoring, and homeland security.Our long-term goal is to catalyze the progress of biomedical, analytical and forensic research through the development of mass spectrometric instrumentation. Once the capabilities of the new devices and methods are understood, controlled and optimized, selected applications are sought to demonstrate the benefits of the new instrumentation to the broader scientific community.
We have recently secured NSF funding to construct a new type of mass spectrometer that should be readily miniaturized into a hand portable unit. This device is in the preliminary stages of development, but is a very exciting new area of research for us.
We also have NSF funding to support our developments in ion trap mass spectrometry. Here we are modifying the software of commercial and modified instruments to operate the traps in new and faster ways. We are also in the process of coupling our ion traps with fast and high-resolution separation methods such as fast GC and fast HPLC methods.
One of our other areas of research involves forensic applications of GC-Combustion-Isotope Ratio Mass Spectrometer (GC-C-IRMS).
Current projects include:
See our website for more details about these and other projects in our group.
S. L. Cook, G. P. Jackson, "Characterization of Tyrosine Nitration and Cysteine Nitrosylation Modifications by Metastable Atom-Activation Dissociation Mass Spectrometry"J. Am. Soc. Mass Spectrom. 2011, 22, 221-232.
Z. Muccio, G. P. Jackson, "Simultaneous Identification and Classification of Drugs Using GC with Concurrent Single Quadrupole and Isotope Ratio Mass Spectrometers" J. Forens. Sci. 2011, 56(S1), S203-209.
X. Sun, C. M. Zimmermann, G. P. Jackson, C. E. Bunker, P. B. Harrington, "Classification of Jet Fuels by Fuzzy Rule-Building Expert Systems Applied to Two-Way Data by Fast Gas Chromatography-Fast Scanning Quadrupole Ion Trap Mass Spectrometry" Talanta. 2011, 83, 1260-1268.
S. I. M. Paris, Ü. A. Laskay, Shengwen Liang, O. Pavlyuk, S. Tschirschwitz, P. Lönnecke, M. C. McMills, G. P. Jackson, J. L. Petersen, E. Hey-Hawkins, M. P. Jensen "Manganese(II) Complexes of di-2-Pyridinylmethylene-1,2-diimine di-Schiff Base Ligands: Structures and Reactivity" Inorg. Chim. Acta. 2010, 363(13), 3390-3398.
C. M. Zimmermann, G. P. Jackson, "Gas Chromatography Tandem Mass Spectrometry for Biomarkers of Alcohol Abuse in Human Hair" Ther. Drug Monit. 2010, 32(2), 216-223.
A. Baum, Y. Lu, Z. Muccio, G. P. Jackson, P. B. Harrington, "Differentiation between Origins of Extra Virgin Olive Oils by GC/C/IRMS using Principal Component Analysis, Linear Discriminant Analysis and Hierarchical Cluster Analysis" Spectroscopy 2010, 25(2) 40-47.
S. L. Cook, Ü. A. Laskay, G. P. Jackson, "Metastable Atom-Activated Dissociation Mass Spectrometry (MAD-MS) for the Determination of Phosphorylation Sites and Leucine/Isoleucine Residues" J. Mass Spectrom. 2009, 44, 1211-1223.
G. P. Jackson, "The Status of Forensic Science Degree Programs in the US" Forens. Sci. Pol. Manage. 2009, 1, 2-9.
O. L. Collin, C. M. Zimmermann, G. P. Jackson, "Fast Gas Chromatography Negative Chemical Ionization Mass Spectrometry of Explosive Compounds" Int. J. Mass Spectrom. 2009, 279, 93-99.
Z. Muccio, G. P. Jackson, "Isotope Ratio Mass Spectrometry" (MiniReview) Analyst, 2009, 134, 213-222.
C. A. Zimmermann, Ü. A. Laskay, G. P. Jackson, "Analysis of Suspected Trace Human Remains From an Indoor Concrete Surface" J. Forens. Sci. 2008, 53(6) 1437-1442.
Ü. A. Laskay, G. P. Jackson, "Resonance Excitation and Dynamic Collision Induced Dissociation in Quadrupole Ion Traps Using Higher-Order Excitation Frequencies" Rapid Commun. Mass Spectrom. 2008, 22(15), 2342-2348.
C. A. Zimmermann, Ü. A. Laskay, G. P. Jackson, "Analysis of Suspected Trace Human Remains From an Indoor Concrete Surface" J. Forens. Sci. submitted.
Ü. A. Laskay, O. L. Collin, J. J. Hyland, Brad. Nichol, S. P. Pasilis, D. C. Duckworth, G. P. Jackson, "Dynamic Collision-Induced Dissociation (DCID) a Quadrupole Ion Trap Using a Two-Frequency Excitation Waveform: II. Effects of Excitation Frequency and Scan Rate" J. Am. Soc. Mass Spectrom. 18 2007 2017-2025.
O. L. Collin, M. Beier, G. P. Jackson, "Dynamic Collision-Induced Dissociation (DCID) of Peptide Ions in a Quadrupole Ion Trap Mass Spectrometer" Anal. Chem. 79 2007 5468-5473.
Ü. A. Laskay, J. J. Hyland, G. P. Jackson, "Dynamic Collision-Induced Dissociation (DCID) a Quadrupole Ion Trap Using a Two-Frequency Excitation Waveform: I. Effects of Excitation Amplitude and Phase Angle" J. Am. Soc. Mass Spectrom. 18, 2007 749-761.
O. L. Collin, C. Niegel, K. E. DeRhodes, B. R. McCord, G. P. Jackson, "Fast-GC of Explosive Compounds Using a Pulsed Discharge Electron Capture Detector" J. Forensic Sci. 51(4) 2006 815-818.
G. P. Jackson, J. J. Hyland, Ü. A. Laskay, "Energetics and Efficiencies of Collision-Induced Dissociation Achieved During Mass Acquisition in a Quadrupole Ion Trap Mass Spectrometer," Rapid Commun. Mass Spectrom. 19, 2005 3555-3563.
G. P. Jackson, D. C. Duckworth, "Electrospray Mass Spectrometry of Undiluted Ionic Liquids," Chem Comm. 5 2004 522-523
G. P. Jackson, F. L. King, D. C. Duckworth, "Efficient Polyatomic Interference Reduction in Plasma-Source Mass Spectrometry Via Collision Induced Dissociation," J. Anal. Atom. Spectrosc. 18(9) 2003 1026-1032.
G. P. Jackson, F. L. King, "Bulk Plasma Properties in the Pulsed Glow Discharge," Spectrochimica Acta, Part B., 58 (8) 2003 1417-1433.
G. P. Jackson, R. G. Haire, D. C. Duckworth, "A New Glow Discharge Source with Enhanced Ion Extraction for Small Non-Conductive Samples and Atmospheric Sampling," J. Anal. Atom. Spectrosc., 18(6) 2003 665-669.