IACUC Policy 015: Use of Non-Pharmaceutical Grade Compounds in Live Vertebrate Animals

1. Purpose: The purpose of this policy is to ensure the responsible and ethical use of non-pharmaceutical grade compounds in live vertebrate animals in accordance with federal guidelines and Ohio University’s PHS Assurance.

2. Scope: This policy applies to all research personnel proposing the use of non-pharmaceutical grade chemical compounds in live vertebrate animals. Such use requires prior review and approval by the IACUC, with scientific justification and/or documentation of unavailability of pharmaceutical-grade alternatives.

3. Policy: Pharmaceutical grade medications are standard for use, even in acute procedures, when they are available.  Non-pharmaceutical grade chemical compounds should only be used after review and approval by the IACUC.  Justification must be provided for use, including scientific necessity and/or lack of availability for a pharmaceutical-grade medication.  For more specifics, see the Guide, Eighth Edition, page 31.