Summer Undergraduate Research Fellowship
Tentative Dates - June 3 - July 13, 2018
The application for SURF 2018 will be available on October 1, 2017. The application deadline is February 1, 2018.
Apply in October Participants in the SURF program work in an active research laboratory under the guidance of a faculty member with the goal of exposing students to the challenges, excitement and satisfaction of research.
Selection is based on academic records and the appropriateness of the applicant’s scientific interests. Students about to begin their senior year of college studies are preferred, but promising juniors and recent graduates will be considered.
Participants are provided with room, board, a modest living allowance and up to $350 travel reimbursement. Six undergraduate credit hours in biology are also available tuition-free to all program participants. In addition, those program participants who meet minimum requirements for admission to the Heritage College, including having taken the MCAT, will be offered an opportunity to interview during the summer.
**Important note to those who may have already applied to our medical school through AACOMAS. You will need to use the same email address for your SURF application as you did on your AACOMAS application.
The button above will take you to our application log in screen. Select the New Applicant Registration link at the bottom to set up your account. Once your account has been set up, you can select the link to apply to SURF.
Once you are in the application portal, you will be able to complete the application at your own pace and you may save and come back to the form as needed. The portal will also be the place to check on the status of your application.
SURF 2017 Faculty Mentors
You will be able to select up to five faculty mentors below with whom you would like to work. Please rank them in order of preference on your application essay.
Research mentors and projects may be subject to change.
Ronan Carroll, Ph.D.
Control of toxin production and secretion in Staphylococcus aureusand methicillin resistant S. aureus (MRSA). Identification and characterization of small RNAs and their role in S. aureusinfection.
Brian Clark, Ph.D.
The overall goal of my research is to develop effective and implementable interventions that increase muscle function (e.g., muscle strength, motor control, fatigue-resistance) and physical performance in older adults, and/or patients with orthopedic and neurologic disabilities for preventative and rehabilitation medicine. I have expertise and experience with basic and applied science human physiology experiments as well as randomized controlled trials (including phase 1 and 2 trials). As such, my work is in the area of ‘translational physiology’, as it sits at the intersection of the bench and bedside. Within this scope my laboratory maintains programmatic efforts in two focused areas: 1) the causes of low back pain and non-surgical strategies to alleviate low back pain, and 2) the causes of impaired muscle function (e.g., muscle weakness, fatigue, unsteadiness) in the elderly and interventional strategies to enhance muscle and physical function in elders. The research across these foci has an overarching aim of developing interventions that remove barriers to independent physical mobility and ultimately reduce disability.
Robert Colvin, Ph.D.
Our current research is focused on delineating the molecular mechanisms underlying the neurodegeneration that occurs in a variety of disorders such as cerebral ischemia and Alzheimer's Disease. Zinc is quite abundant in the brain. It is an essential trace element required as a co-factor for several metalloproteins (e.g., transcription factors, metalloenzymes), but may also have signaling functions too. Like most other things in life, too much zinc is not good for cell survival. High levels of zinc inside cells, kill them, so there are several cellular mechanisms for maintaining intracellular zinc concentrations within a narrow range. One important mechanism is zinc transporters, but very little is known about these proteins. Elevations of intracellular zinc may contribute to glutamate excitotoxicity (a mechanism of neuron death in stroke) and play a role in Alzheimer's disease pathology. We are using several different techniques to study zinc transport. These include direct measurement of the zinc transport function in primary cell culture and various imaging techniques using fluorescent dyes.
Karen Coschigano, Ph.D.
The main research focus of my laboratory is the identification of genes, proteins and regulatory pathways involved in the development of diabetic nephropathy, or kidney damage, with an emphasis on the roles of growth hormone, STAT5 and inflammation. My group uses mouse models, cell culture and gene expression assays including real-time RT/PCR, western blot and immunohistochemical analyses. We are also using bioinformatics to evaluate gene expression.
Janet Duerr, Ph.D.
Our research uses a model organism, the nematode Caenorhabditis elegans, to examine the development and function of the nervous system. C. elegans is a small animal which uses many of genes found in humans to regulate the 302 neurons in its very simple nervous system. We use genetics (including transgenic animals), molecular biology, cell biology, microscopy, and behavioral assays to examine two major questions. One, how is neurotransmission by monoamines (e.g., serotonin and dopamine) regulated by specific genes and drugs? In particular, what are the effects of monoamine oxidase inhibitors (prescribed drugs that increase levels of dopamine and serotonin) on the development and function of neurons? Two, how do epigenetic changes such as histone modifications regulate the development function of the nervous system? In particular, what are the effects of histone demethylases on neuronal function? We expect that understanding changes in this simple animal will increase our understanding of much more complex regulation in humans.
Mario Grijalva, Ph.D.
Tropical Disease Research in Ecuador: Epidemiological, entomological and clinical studies in rural communities of Ecuador. Activities will focus on collection and analysis of biological material in the field (mobile laboratory) and further analysis of samples and data at the Center for Research on Health in Latin America in Quito, Ecuador. This experience entails travel to Ecuador.
John Kopchick, Ph.D.
Molecular basis of aging, growth hormone action, obesity and diabetes.
Kevin Lee, Ph.D.
Defining the Intrinsic Heterogeneity of Adipose Tissue
:The global increase in obesity is a major force driving the epidemic of type 2 diabetes. Over the past decade it has become clear that both obesity and adipose tissue are more complex than originally believed. Recent research from my laboratory has found that adipocytes are heterogeneous in nature, arise from different developmental lineages, and have distinct phenotypic properties.
The central goal of my laboratory is to understand at a molecular and cellular level what accounts for heterogeneity between white adipocyte subpopulations and to study the effect these different adipocyte subpopulations have on systemic metabolism. To this end, we have developed novel cell and mouse models to study adipocyte biology. Knowledge gained from this research will aid in the identification of specific markers and the development of therapeutic approaches to combat the metabolic disorders associated with obesity.
In addition to critical thinking and experimental design, students participating in the laboratory would learn standard molecular biology techniques (gel electrophoresis, PCR, western blot, immunohistochemistry), as well as cell culture, mouse genetics, state of the art confocal microscopy, and lineage tracing analysis.
Chunmin Lo, Ph.D.
My research interest focuses on control of energy intake and expenditure, glucose homeostasis, and lipid transport / metabolism.
I have investigated that cholecystokinin (CCK) and apolipoprotein AIV (ApoAIV) are involved in the regulation of insulin sensitivity, insulin secretion, and glucose homeostasis and lipid metabolism.
I have also studied the effect of ApoAIV and CCK on the control of energy homeostasis and the neuronal activation in the hypothalamus.
I have extensive experience in the study of lipid transport and metabolism, especially in chylomicrons and lipoproteins, and secretion of gut peptides and incretins.
Don Miles, Ph.D.
Responses of ectothermic (“cold-blooded) organisms to climate warming, thermal and biophysical ecology of lizards, Diversity in mating systems and alternative mating strategies, evolution of adaptive phenotypic plasticity as a strategy for coping with fluctuating environments, ecological opportunity, habitat variation and adaptive radiations.
Erin Murphy, Ph.D.
My research focuses on understanding how bacteria control the production of disease-associated factors in response to specific environmental conditions encountered within the human host. We are particularly interested in Shigella dysenteriae and how this disease causing bacterium utilizes regulatory RNA molecules to control the production and/or activity of disease-associated factors. Research in my laboratory utilizes many standard molecular biology techniques including, but not limited to, DNA cloning, gene mutation, Real-time PCR as well as western and northern blot analyses.
Corinne Nielsen, Ph.D.
Genetic regulation of mammalian neurovascular development, physiology and pathophysiology. Identification of mechanisms involved in: 1) brain vascular development/morphogenesis and 2) a neurovascular disease called brain arteriovenous malformation. Experimental approaches include mouse genetics, molecular and cell biology, and microscopy.
Allan Showalter, Ph.D.
Molecular and cellular biology approaches to the structure, biosynthesis and function of plant cell surface proteins, including the use of genetic mutants and transgenics in Arabidopsis. DNA barcoding of medicinal plants to authenticate plant material and detect potential adulterants.
Tomohiko Sugiyama, Ph.D.
We are studying the mechanisms of DNA homologous recombination, DNA repair, and mutagenesis. By using purified proteins and model DNA substrates, we are investigating the details of biochemical processes of DNA repair/recombination. We are also working on the mechanisms of repair error, which cause mutations.
Soichi Tanda, Ph.D.
One of research projects in my lab is to elucidate genetic relationships of Clic5a to genes involved in remodeling actin cytoskeleton in mice. Clic5a is one of essential proteins to link actin bundles to plasma membrane of stereocilia of hair cells in the inner ear. Thus, loss of Clic5a leads to deafness in mice as well as humans. To understand how Clic5a works with other actin cytoskeleton modulators, I am planning to create Clic5a mutants with mutations of these modulators for their genetic interaction. Morphologies of stereoscilia will be examined by staining of actin with confocal microscopy.
Sarah Wyatt, Ph.D.
We use genetic, molecular and bioinformatics analyses to identify components of plant signaling pathways responsible for responses to gravitropism on Earth and the space flight environment.