Chunmin  Lo, PhD

Assistant Professor

HCOM-Biomedical Sciences

Academic Research Center 302A

740.593.2328

Member Type: Investigator  

Research Interest

My long-term research interests involve the roles of apolipoproteins and other endogenous compounds in the control of energy homeostasis, lipid metabolism and glucose regulation, and pathogenesis of obesity and diabetes.

My research focuses on:

  1. Neural regulation of energy homeostasis and lipid metabolism induced by Apolipoprotein AIV
  2. Modulation of glucose homeostasis and neuroendocrine system by cholecystokinin and other gut peptides
  3. The role of intestinal hormones and hypothalamic neuropeptides induced by nutrients in controlling lipid/glucose metabolism and neurophysiology as well as the relationship with obesity and diabetes

Selected Publications

Zhan, J., Weng, J., Hunt, B. G., Sean Davidson, W., Liu, M., & Lo, C. C. (2018). Apolipoprotein A-IV enhances cholecystokinnin secretion. Physiology & Behavior, 188, 11–17. 

Shen, L., Lo, C. C., Woollett, L. A., & Liu, M. (2017). Apolipoprotein A-IV exerts its anorectic action through a PI3K/Akt signaling pathway in the hypothalamus. Biochemical and Biophysical Research Communications, 494(1–2), 152–157. 

Weng, J., Lou, D., Benoit, S. C., Coschigano, N., Woods, S. C., Tso, P., & Lo, C. C. (2017). Energy homeostasis in apolipoprotein AIV and cholecystokinin-deficient mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 313(5), R535–R548. 

Shen, L., Haas, M., Wang, D. Q.-H., May, A., Lo, C. C., Obici, S., … Liu, M. (2015). Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats. Physiological Reports, 3(9). 

King, A., Yang, Q., Huesman, S., Rider, T., & Lo, C. C. (2015). Lipid transport in cholecystokinin knockout mice. Physiology & Behavior, 151, 198–206. 

Lo, C. C., Davidson, W. S., Hibbard, S. K., Georgievsky, M., Lee, A., Tso, P., & Woods, S. C. (2014). Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats. Endocrinology, 155(5), 1700–1707. 

Lo, C. C., Langhans, W., Georgievsky, M., Arnold, M., Caldwell, J. L., Cheng, S., … Tso, P. (2012). Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake. Endocrinology, 153(12), 5857–5865. 

Lo, C.-M., Obici, S., Dong, H. H., Haas, M., Lou, D., Kim, D. H., … Tso, P. (2011). Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice. Diabetes, 60(7), 2000–2007. 

Lo, C.-M., King, A., Samuelson, L. C., Kindel, T. L., Rider, T., Jandacek, R. J., … Tso, P. (2010). Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity. Gastroenterology, 138(5), 1997–2005. 

Lo, C.-M., Xu, M., Yang, Q., Zheng, S., Carey, K. M., Tubb, M. R., … Tso, P. (2009). Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 296(1), R43-50.