Craig  Nunemaker, PhD

Associate Professor

HCOM-Biomedical Sciences

Academic Center 302C


Member Type: Investigator  

Research Interest

My research focuses on identifying and characterizing the early warning signs of beta-cell decline that precede the onset type 2 diabetes. My work has provided proof-of-principle that circulation levels of proinflammatory cytokines caused by obesity are sufficient to trigger beta-cell failure in diabetes-prone individuals. Current efforts focus on identifying novel genes and pathways involved in beta-cell stress responses related to chronic low-grade inflammation.

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Selected Publications

Nunemaker, C. S., & Li, C. (2017). Can NMDA Receptors Get β-Cells Toxically Excited? Endocrinology, 158(11), 3709–3710. 

Scarl, R. T., Lawrence, C. M., Gordon, H. M., & Nunemaker, C. S. (2017). STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper. The Journal of Endocrinology, 234(3), R123–R134.

Gordon, H. M., Majithia, N., MacDonald, P. E., Fox, J. E. M., Sharma, P. R., Byrne, F. L., … Nunemaker, C. S. (2017). STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation. Endocrine, 56(3), 528–537. 

Nunemaker, C. S., & Benninger, R. K. P. (2016). Zinc Transport Gets Its Zing Back: Double-Knockout of ZnT7 and ZnT8 Reveals the Importance of Zinc Transporters to Insulin Secretion. Endocrinology, 157(12), 4542–4544. 

Whitticar, N. B., Strahler, E. W., Rajan, P., Kaya, S., & Nunemaker, C. S. (2016). An Automated Perifusion System for Modifying Cell Culture Conditions over Time. Biological Procedures Online, 18, 19. 

Nunemaker, C. S. (2016). Considerations for Defining Cytokine Dose, Duration, and Milieu That Are Appropriate for Modeling Chronic Low-Grade Inflammation in Type 2 Diabetes. Journal of Diabetes Research, 2016, 2846570. 

Corbin, K. L., Waters, C. D., Shaffer, B. K., Verrilli, G. M., & Nunemaker, C. S. (2016). Islet Hypersensitivity to Glucose Is Associated With Disrupted Oscillations and Increased Impact of Proinflammatory Cytokines in Islets From Diabetes-Prone Male Mice. Endocrinology, 157(5), 1826–1838. 

Sharma, P. R., Mackey, A. J., Dejene, E. A., Ramadan, J. W., Langefeld, C. D., Palmer, N. D., … Nunemaker, C. S. (2015). An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes. Endocrinology, 156(9), 3147–3156. 

Qureshi, F. M., Dejene, E. A., Corbin, K. L., & Nunemaker, C. S. (2015). Stress-induced dissociations between intracellular calcium signaling and insulin secretion in pancreatic islets. Cell Calcium, 57(5–6), 366–375. 

O’Neill, C. M., Lu, C., Corbin, K. L., Sharma, P. R., Dula, S. B., Carter, J. D., … Nunemaker, C. S. (2013). Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology, 154(9), 3077–3088.