Kelly  McCall, PhD

Associate Professor, Specialty Medicine

HCOM-Specialty Medicine

Academic Research Center 302B

740.593.0926

Member Type: Investigator  

Research Interest

 I am interested in the pathogenesis of a multitude of autoimmune-inflammatory diseases including both type I and type II diabetes, a variety of human cancers (i.e. thyroid, pancreatic, prostate, breast, colon, and malignant melanoma), colitis, toxic shock, and atherosclerosis.  Specifically, my current focus is on Toll-Like Receptors and their involvement in the pathogenesis and progression of the aforementioned diseases.

Selected Publications

Szulawski, R., Nakazawa, M., McCall, K. D., James, C. B. L., & Schwartz, F. L. (2016). Laser capture microdissection tailored to type 1 diabetes mellitus research. BioTechniques, 60(6), 293–298. 

Guo, A., Daniels, N. A., Thuma, J., McCall, K. D., Malgor, R., & Schwartz, F. L. (2015). Diet is critical for prolonged glycemic control after short-term insulin treatment in high-fat diet-induced type 2 diabetic male mice. PloS One, 10(1), e0117556.

McCall, K. D., Thuma, J. R., Courreges, M. C., Benencia, F., James, C. B. L., Malgor, R., … Schwartz, F. L. (2015). Toll-like receptor 3 is critical for coxsackievirus B4-induced type 1 diabetes in female NOD mice. Endocrinology, 156(2), 453–461. 

Deosarkar, S. P., Bhatt, P., Gillespie, J., Goetz, D. J., & McCall, K. D. (2014). Inhibition of LPS-induced TLR4 signaling products in murine macrophages by phenylmethimazole: an assay methodology for screening potential phenylmethimazole analogs. Drug Development Research, 75(8), 497–509. 

Malgor, R., Bhatt, P. M., Connolly, B. A., Jacoby, D. L., Feldmann, K. J., Silver, M. J.,  Nakazawa, M.,  McCall, K. D., & Goetz, D. J. (2014). Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions. Inflammation Research: Official Journal of the European Histamine Research Society... [et Al.], 63(4), 277–285. 

McCall, K. D., Schmerr, M. J., Thuma, J. R., James, C. B. L., Courreges, M. C., Benencia, F., … Schwartz, F. L. (2013). Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice. Molecules (Basel, Switzerland), 18(4), 3841–3858.

McCall, K. D., Holliday, D., Dickerson, E., Wallace, B., Schwartz, A. L., Schwartz, C., … Schwartz, F. L. (2010). Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages. The Journal of Endocrinology, 207(3), 343–353.