John  Kopchick, PhD

Goll-Ohio Eminent Scholar, Professor, Molecular Biology

HCOM / EBI

Konneker Research Center 206A

740.593.4534

Member Type: Investigator  

Research Interest

 My research focuses on: 

  • Use of a proteomic platform to identify new biomarkers of pre-diabetes, aging, GH doping, and white adipose depot physiology

  • Use of a Growth Hormone receptor antagonist to ascertain Growth Hormone's anti-insulin (diabetogenic) action

  • Function of the Growth Hormone Receptor in liver, adipose, and muscle tissue as it relates to insulin resistance and aging

  • Function of Growth Hormone Binding Protein as it relates to GH's diabetogenic activity.

Selected Publications

Soendergaard, C., Kvist, P. H., Thygesen, P., Reslow, M., Nielsen, O. H., Kopchick, J. J., & Holm, T. L. (2017). Characterization of Growth Hormone Resistance in Experimental and Ulcerative Colitis. International Journal of Molecular Sciences, 18(10).

Brittain, A. L., Basu, R., Qian, Y., & Kopchick, J. J. (2017). Growth Hormone and the Epithelial-to-Mesenchymal Transition. The Journal of Clinical Endocrinology and Metabolism, 102(10), 3662–3673. 

Consitt, L. A., Saneda, A., Saxena, G., List, E. O., & Kopchick, J. J. (2017). Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass. Skeletal Muscle, 7(1), 17.

Kopchick, J. J., & Johannsson, G. (2017). Meeting Reports: The 25th Anniversary of the Growth Hormone Research Society Lisbon, Portugal, May 20, 2017. Pediatric Endocrinology Reviews : PER, 15(1), 53–56.

Duran-Ortiz, S., Brittain, A. L., & Kopchick, J. J. (2017). The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies. Clinical Proteomics, 14, 24. 

Troike, K. M., Henry, B. E., Jensen, E. A., Young, J. A., List, E. O., Kopchick, J. J., & Berryman, D. E. (2017). Impact of Growth Hormone on Regulation of Adipose Tissue. Comprehensive Physiology, 7(3), 819–840. 

Cady, G., Landeryou, T., Garratt, M., Kopchick, J. J., Qi, N., Garcia-Galiano, D., … Sadagurski, M. (2017). Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Molecular Metabolism, 6(5), 393–405. 

Hjortebjerg, R., Berryman, D. E., Comisford, R., Frank, S. J., List, E. O., Bjerre, M., … Kopchick, J. J. (2017). Insulin, IGF-1, and GH Receptors Are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice With Modified GH Action. Endocrinology, 158(5), 1406–1418. 

Bennis, M. T., Schneider, A., Victoria, B., Do, A., Wiesenborn, D. S., Spinel, L., Gensing, A., Kopchick, J. J., Siddiqi, S. A., Masternak, M. M. (2017). The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling. GeroScience, 39(1), 51–59. 

List, E. O., Jensen, E., Kowalski, J., Buchman, M., Berryman, D. E., & Kopchick, J. J. (2016). Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice. Nutrition and Healthy Aging, 4(1), 95–99.

Junnila, R. K., Duran-Ortiz, S., Suer, O., Sustarsic, E. G., Berryman, D. E., List, E. O., & Kopchick, J. J. (2016). Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females. Endocrinology, 157(12), 4502–4513.

Sadagurski, M., Landeryou, T., Cady, G., Kopchick, J. J., List, E. O., Berryman, D. E., … Miller, R. A. (2015). Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice. Aging Cell, 14(6), 1045–1054. 

Stout, M. B., Tchkonia, T., Pirtskhalava, T., Palmer, A. K., List, E. O., Berryman, D. E., Lubbers, E. R., Escande, C., Sponq, A., Masternak, M. M., Oberq, A. L., LeBrasseur, N. K., Miller, R. A., Kopchick, J. J., Bartke, A., Kirkland, J. L. (2014). Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging, 6(7), 575–586. 

List, E. O., Berryman, D. E., Funk, K., Jara, A., Kelder, B., Wang, F., … Kopchick, J. J. (2014). Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology, 155(5), 1793–1805. 

List, E. O., Berryman, D. E., Funk, K., Gosney, E. S., Jara, A., Kelder, B., … Kopchick, J. J. (2013). The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Molecular Endocrinology (Baltimore, Md.), 27(3), 524–535.

Masternak, M. M., Bartke, A., Wang, F., Spong, A., Gesing, A., Fang, Y., Salmon, A., Hughes, L. F., Liberati, T., Boparai, R., Kopchick, J. J.,  Westbrook, R. (2012). Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell, 11(1), 73–81.