Leslie Consitt, PhD
Assistant Professor, Physiology
Academic Research Center 302E
Member Type: Investigator
The overall aim of my research is to investigate the development and treatment of metabolic diseases associated with excess nutritional lipid intake and/or physical inactivity. I am particularly focused on elucidating the cellular mechanisms controlling skeletal muscle glucose and lipid metabolism and how impairments in these mechanisms contribute to insulin resistance in conditions such as obesity, diabetes, and aging. I use a combination of human, animal, and cell culture models to identify cellular mechanisms that contribute to skeletal muscle insulin resistance and use interventions such as exercise and diet modification to help correct cellular impairments.
Consitt, L. A., Saneda, A., Saxena, G., List, E. O., & Kopchick, J. J. (2017). Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass. Skeletal Muscle, 7(1), 17.
Consitt, L. A., Koves, T. R., Muoio, D. M., Nakazawa, M., Newton, C. A., & Houmard, J. A. (2016). Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction. Biochemical and Biophysical Research Communications, 479(4), 868–874.
Consitt, L. A., Saxena, G., Saneda, A., & Houmard, J. A. (2016). Age-related impairments in skeletal muscle PDH phosphorylation and plasma lactate are indicative of metabolic inflexibility and the effects of exercise training. American Journal of Physiology. Endocrinology and Metabolism, 311(1), E145-156.
Consitt, L. A., Van Meter, J., Newton, C. A., Collier, D. N., Dar, M. S., Wojtaszewski, J. F. P., … Houmard, J. A. (2013). Impairments in site-specific AS160 phosphorylation and effects of exercise training. Diabetes, 62(10), 3437–3447.
Boyle, K. E., Canham, J. P., Consitt, L. A., Zheng, D., Koves, T. R., Gavin, T. P., … Houmard, J. A. (2011). A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. The Journal of Clinical Endocrinology and Metabolism, 96(3), 775–781.
Bell, J. A., Reed, M. A., Consitt, L. A., Martin, O. J., Haynie, K. R., Hulver, M. W., … Dohm, G. L. (2010). Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression. The Journal of Clinical Endocrinology and Metabolism, 95(7), 3400–3410.
Consitt, L. A., Bell, J. A., Koves, T. R., Muoio, D. M., Hulver, M. W., Haynie, K. R., … Houmard, J. A. (2010). Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals. Diabetes, 59(6), 1407–1415.