Xiaozhuo  Chen, PhD

Associate Professor, Microbiology

HCOM-Biomedical Sciences / EBI

Konneker Research Center 109

740.593.9699

Member Type: Investigator  

Research Interest

My research focuses on glucose transport and glucose metabolism in cancer and diabetes; signal transduction of insulin mediated pathways in diabetes and insulin resistance; role of adipogenisis in obesity and type 2 diabetes; anit-diabetic and anticancer compounds from natural and synthetic sources; basal glucose transport and apoptosis in cancer cells.

 

Selected Publications

Qian, Y., Wang, X., Li, Y., Cao, Y., & Chen, X. (2016). Extracellular ATP a New Player in Cancer Metabolism: NSCLC Cells Internalize ATP In Vitro and In Vivo Using Multiple Endocytic Mechanisms. Molecular Cancer Research: MCR, 14(11), 1087–1096.

Granchi, C., Qian, Y., Lee, H. Y., Paterni, I., Pasero, C., Iegre, J., Carlson, K. E., Tuccinardi, T., Chen, X.,  … Minutolo, F. (2015). Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells. ChemMedChem, 10(11), 1892–1900. 

Liu, X., Malki, A., Cao, Y., Li, Y., Qian, Y., Wang, X., & Chen, X. (2015). Glucose- and Triglyceride-lowering Dietary Penta-O-galloyl-α-D-Glucose Reduces Expression of PPARγ and C/EBPα, Induces p21-Mediated G1 Phase Cell Cycle Arrest, and Inhibits Adipogenesis in 3T3-L1 Preadipocytes. Experimental and Clinical Endocrinology & Diabetes: Official Journal, German Society of Endocrinology [and] German Diabetes Association, 123(5), 308–316. 

Cao, Y., Himmeldirk, K. B., Qian, Y., Ren, Y., Malki, A., & Chen, X. (2014). Biological and biomedical functions of Penta-O-galloyl-D-glucose and its derivatives. Journal of Natural Medicines, 68(3), 465–472.

Cao, Y., Li, Y., Kim, J., Ren, Y., Himmeldirk, K., Liu, Y., … Chen, X. (2013). Orally efficacious novel small molecule 6-chloro-6-deoxy-1,2,3,4-tetra-O-galloyl-α-D-glucopyranose selectively and potently stimulates insulin receptor and alleviates diabetes. Journal of Molecular Endocrinology, 51(1), 15–26. 

Liu, Y., Cao, Y., Zhang, W., Bergmeier, S., Qian, Y., Akbar, H., … Chen, X. (2012). A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Molecular Cancer Therapeutics, 11(8), 1672–1682.