Darlene  Berryman, PhD, RD, LD

Professor, Nutrition


Irvine 220B


Member Type: Investigator  

Research Interest

The unifying theme of my scholarly work is obesity. I am fortunate to be able to address this timely subject from two different perspectives, mainly as a basic scientist but occasionally as a clinician. The majority of my scholarly efforts are to assess the nutritional and hormonal factors that impact adipose (fat) tissue and influence risk of obesity as well as its associated diseases. More specifically, I investigate how growth hormone (GH) levels and diets with various macronutrient profiles impact adipose tissue distribution, metabolism, and function as well as the progression of obesity to overt diabetes. Because GH and diet also have been shown to manipulate longevity, I am interested in how these factors influence aging.

Selected Publications

Lee, K. Y., Sharma, R., Gase, G., Ussar, S., Li, Y., Welch, L., Berryman, D.E., Kispert, A., Bluher, M., & Kahn, C. R. (2017). Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity. Diabetes

Troike, K. M., Henry, B. E., Jensen, E. A., Young, J. A., List, E. O., Kopchick, J. J., & Berryman, D. E. (2017). Impact of Growth Hormone on Regulation of Adipose Tissue. Comprehensive Physiology, 7(3), 819–840.

Hjortebjerg, R., Berryman, D. E., Comisford, R., Frank, S. J., List, E. O., Bjerre, M., … Kopchick, J. J. (2017). Insulin, IGF-1, and GH Receptors are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice with Modified GH Action. Endocrinology

List, E. O., Jensen, E., Kowalski, J., Buchman, M., Berryman, D. E., & Kopchick, J. J. (2016). Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice. Nutrition and Healthy Aging, 4(1), 95–99. 

Junnila, R. K., Duran-Ortiz, S., Suer, O., Sustarsic, E. G., Berryman, D. E., List, E. O., & Kopchick, J. J. (2016). Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females. Endocrinology, 157(12), 4502–4513. 

Brooks, N. E., Hjortebjerg, R., Henry, B. E., List, E. O., Kopchick, J. J., & Berryman, D. E. (2016). Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice. Growth Hormone & IGF Research: Official Journal of the Growth Hormone Research Society and the International IGF Research Society, 30–31, 22–30. 

Berryman, D. E., Henry, B., Hjortebjerg, R., List, E. O., & Kopchick, J. J. (2016). Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinic. Expert Review of Endocrinology & Metabolism, 11(2), 197–207. 

Benencia, F., Harshman, S., Duran-Ortiz, S., Lubbers, E. R., List, E. O., Householder, L., … Berryman, D. E. (2015). Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations. Endocrinology, 156(5), 1794–1803.

Palmer, A. J., Chung, M.-Y., List, E. O., Walker, J., Okada, S., Kopchick, J. J., & Berryman, D. E. (2009). Age-related changes in body composition of bovine growth hormone transgenic mice. Endocrinology, 150(3), 1353–1360. 

Berryman, D. E., List, E. O., Coschigano, K. T., Behar, K., Kim, J. K., & Kopchick, J. J. (2004). Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Hormone & IGF Research: Official Journal of the Growth Hormone Research Society and the International IGF Research Society, 14(4), 309–318.