Yunpeng Wu, MD, PhD
- Medicine (MD), Shanghai Medical University, 1988
- Molecular and Cellular Biology, Ohio University, 1997
- American Board of Internal Medicine, 2007
- Sleep Medicine, ABIM, 2013
- Sleep Disorders, Sleep Related Breathing Disorder, Obstructive Sleep Apnea, Narcolepsy, Restless Leg Syndrome, Hypersomnia, Insomnia, Circadian Rhythm Sleep Disorder, REM Sleep Related Behavior Disorder, Parasomnia, Sleep Walk and Eating Disorder, Positive Airway Pressure Management
- Interpretation of Polysomnography, Actigraphy, Multiple Sleep Latency Test, Maintenance Wakefulness Test, Sleep Log
- Specialized in prevention, diagnosis and management of adult diseases, chronic, acute and critical care, EKG and stress test
The current work is to investigate the impact of Obstructive Sleep Apnea (OSA) and its management in the population of postmenopausal women. The preliminary data suggested that menopause symptoms in physical, sexual and psychosocial domains in patients with OSA were significantly improved after CPAP treatment. Data collection is undergoing in our sleep lab to explore the associations of sleep parameters, four domains of post-menopausal symptoms, and multiple co-morbidities including hypertension, diabetes, cardiac arrhythmia, congestive heart failure, stroke, psychiatric disorder, etc. in the postmenopausal populations in the context of management of OSA. The significant evidences will benefit the improvement of the cares for the postmenopausal women.
The future work will focus on research to explore significant evidences underlying sleep disorders and common morbidities in primary care such as chronic back pain. The aim is to transform the management of comorbidities and improve the outcome in the primary care.
My past work included the identification of the new colon cancer predisposition gene. With international collaboration, genetic linkage analysis, exome sequencing, tumor studies, and functional investigations led to the identification of a truncating germline mutation in RPS20, which encodes a component (S20) of the small ribosomal subunit. Mutations in a gene encoding a ribosomal protein can predispose individuals to microsatellite-stable colon cancer. Please refer to Gastroenterology. 2014 Sep;147(3):595-598.e5. doi: 10.1053/j.gastro.2014.06.009.