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John Kopchick, Ph.D.

Goll-Ohio Eminent Scholar & Professor

HCOM - Biomedical Sciences / EBI 
Konneker Research Center 206A
740-593-4534 
kopchick@ohio.edu

 

Education:  Ph.D. University of Texas MD Anderson Hospital TX 1980

 

Research Interest

 

 My research focuses on: 

  • Use of a proteomic platform to identify new biomarkers of pre-diabetes, aging, GH doping, and white adipose depot physiology

  • Use of a Growth Hormone receptor antagonist to ascertain Growth Hormone's anti-insulin (diabetogenic) action

  • Function of the Growth Hormone Receptor in liver, adipose, and muscle tissue as it relates to insulin resistance and aging

  • Function of Growth Hormone Binding Protein as it relates to GH's diabetogenic activity.

  •   Complete Curriculum Vitae (PDF)

Selected Publications

 

Soendergaard, C., Kvist, P. H., Thygesen, P., Reslow, M., Nielsen, O. H., Kopchick, J. J., & Holm, T. L. (2017). Characterization of Growth Hormone Resistance in Experimental and Ulcerative Colitis. International Journal of Molecular Sciences, 18(10). https://doi.org/10.3390/ijms18102046

 

Brittain, A. L., Basu, R., Qian, Y., & Kopchick, J. J. (2017). Growth Hormone and the Epithelial-to-Mesenchymal Transition. The Journal of Clinical Endocrinology and Metabolism, 102(10), 3662–3673. https://doi.org/10.1210/jc.2017-01000

 

Consitt, L. A., Saneda, A., Saxena, G., List, E. O., & Kopchick, J. J. (2017). Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass. Skeletal Muscle, 7(1), 17. https://doi.org/10.1186/s13395-017-0133-y

 

Kopchick, J. J., & Johannsson, G. (2017). Meeting Reports: The 25th Anniversary of the Growth Hormone Research Society Lisbon, Portugal, May 20, 2017. Pediatric Endocrinology Reviews : PER, 15(1), 53–56. https://doi.org/10.17458/per.vol15.2017.kj.mr.25anniversaryghsociety

 

Duran-Ortiz, S., Brittain, A. L., & Kopchick, J. J. (2017). The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies. Clinical Proteomics, 14, 24. https://doi.org/10.1186/s12014-017-9160-2

 

Troike, K. M., Henry, B. E., Jensen, E. A., Young, J. A., List, E. O., Kopchick, J. J., & Berryman, D. E. (2017). Impact of Growth Hormone on Regulation of Adipose Tissue. Comprehensive Physiology, 7(3), 819–840. https://doi.org/10.1002/cphy.c160027

 

Cady, G., Landeryou, T., Garratt, M., Kopchick, J. J., Qi, N., Garcia-Galiano, D., … Sadagurski, M. (2017). Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Molecular Metabolism, 6(5), 393–405. https://doi.org/10.1016/j.molmet.2017.03.001

 

Hjortebjerg, R., Berryman, D. E., Comisford, R., Frank, S. J., List, E. O., Bjerre, M., … Kopchick, J. J. (2017). Insulin, IGF-1, and GH Receptors Are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice With Modified GH Action. Endocrinology, 158(5), 1406–1418. https://doi.org/10.1210/en.2017-00084

 

Bennis, M. T., Schneider, A., Victoria, B., Do, A., Wiesenborn, D. S., Spinel, L., Gensing, A., Kopchick, J. J., Siddiqi, S. A., Masternak, M. M. (2017). The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling. GeroScience, 39(1), 51–59. https://doi.org/10.1007/s11357-017-9957-y

 

List, E. O., Jensen, E., Kowalski, J., Buchman, M., Berryman, D. E., & Kopchick, J. J. (2016). Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice. Nutrition and Healthy Aging, 4(1), 95–99. https://doi.org/10.3233/NHA-1614

 

Junnila, R. K., Duran-Ortiz, S., Suer, O., Sustarsic, E. G., Berryman, D. E., List, E. O., & Kopchick, J. J. (2016). Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females. Endocrinology, 157(12), 4502–4513. https://doi.org/10.1210/en.2016-1649

 

Sadagurski, M., Landeryou, T., Cady, G., Kopchick, J. J., List, E. O., Berryman, D. E., … Miller, R. A. (2015). Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice. Aging Cell, 14(6), 1045–1054. https://doi.org/10.1111/acel.12382

 

Stout, M. B., Tchkonia, T., Pirtskhalava, T., Palmer, A. K., List, E. O., Berryman, D. E., Lubbers, E. R., Escande, C., Sponq, A., Masternak, M. M., Oberq, A. L., LeBrasseur, N. K., Miller, R. A., Kopchick, J. J., Bartke, A., Kirkland, J. L. (2014). Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging, 6(7), 575–586. https://doi.org/10.18632/aging.100681

 

List, E. O., Berryman, D. E., Funk, K., Jara, A., Kelder, B., Wang, F., … Kopchick, J. J. (2014). Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology, 155(5), 1793–1805. https://doi.org/10.1210/en.2013-2086

 

List, E. O., Berryman, D. E., Funk, K., Gosney, E. S., Jara, A., Kelder, B., … Kopchick, J. J. (2013). The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice. Molecular Endocrinology (Baltimore, Md.), 27(3), 524–535. https://doi.org/10.1210/me.2012-1330

 

Masternak, M. M., Bartke, A., Wang, F., Spong, A., Gesing, A., Fang, Y., Salmon, A., Hughes, L. F., Liberati, T., Boparai, R., Kopchick, J. J.,  Westbrook, R. (2012). Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell, 11(1), 73–81. https://doi.org/10.1111/j.1474-9726.2011.00763.x

 

For more publication please link to PubMed.

More about Dr. Kopchick HERE

 

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