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Amir Farnoud

Assistant Professor
Chemical and Biomolecular Engineering, Biomedical Engineering
Stocker Center 161
farnoud@ohio.edu
Phone: 740.593.1426

Dr. Amir Farnoud joined the Department of Chemical and Biomolecular Engineering in August 2015 after performing post-doctoral training at SUNY-Stony Brook. Focused where biology and nanotechnology, meet, his research group aims to understand the complex phenomena that occur when nanomaterials and biological interfaces collide. Specifically, his group studies nanoparticle interactions with the cell plasma membrane, a lipid bilayer that separates the cell from the outer environment. Current research projects are focused on understanding the mechanisms by which nanomaterials induce damage in the cell membrane of mammalian cells, using nanoparticle-membrane interactions for the development of novel disease screening/diagnosis assays, and developing nanocarriers for site-specific delivery of drugs. 


Research Interests: Biological membranes, lipid bilayers, nanotechnology, cell-nanoparticle interactions

All Degrees Earned: Ph.D., Chemical Engineering, University of Iowa, 2013; M.S., Chemical Engineering-Biotechnology, Tarbiat Modares University, 2007; B.S., Chemical Engineering, University of Tehran

Other (1)

Journal Article, Academic Journal (27)

  • Bigdelou, P., Farnoud, A. (2019). Induction of eryptosis using a calcium ionophore. In press.
  • Vahedi, A., Farnoud, A. (2019). Novel experimental modules to introduce students to nanoparticle characterization in a chemical engineering course. 9. 96 : 2029-2035.
  • Colombo, A., Rella, A., Normile, T., Joffe, L., Tavares, P., Araújo, G., Frases, S., Orner, E., Farnoud, A., Fries, B., Sheridan, B., Nimrichter, L., Rodrigues, M., Del Poeta, M. (2019). Cryptococcus neoformans glucuronoxylomannan and sterylglucoside are required for host protection in an animal vaccination model. 2. Washington DC: 10: e02909-18.
  • Khosravi, Z., Sharma, S., Farnoud, A. (2019). Sub-micron polymeric particles accelerate insulin fibrillation by surface adsorption. In press.
  • Mohammadalipour, A., Showalter, C., Muturi, H., Farnoud, A., Najjar, S., Burdick, M. (2019). Cholesterol depletion decreases adhesion of non-small lung cancer cells to E-selectin.
  • Colombo, A., Rella, A., Normile, T., Joffe, L., Tavares, P., Frases, S., Orner, E., de S. Araújo, G., Farnoud, A., Fries, B., Sheridan, B., Nimrichter, L., Rodrigues, M., Del Poeta, M. (2018). Cryptococcus neoformans glucuronoxylomannan and sterylglucoside are required for host protection in an animal vaccination model.
  • Nazemidashtarjandi, S., Farnoud, A. (2018). Membrane outer leaflet is the primary regulator of membrane damage induced by silica nanoparticles in vesicles and erythrocytes.
  • Farnoud, A., Nazemidashtarjandi, S. (2018). Emerging investigator series: Interactions of engineered nanomaterials with the cell plasma membrane; what have we learned from membrane models?. 6: 13-40.
  • Reynolds, N., Mohammadalipour, A., Hall, C., Asghari Adib, A., Farnoud, A., Burdick, M. (2018). Galectin-1 Influences Breast Cancer Cell Adhesion to E-selectin via Ligand Intermediaries. 1. 11: 37-52.
  • Asghari Adib, A., Nazemidashtarjandi, S., Kelly, A., Kruse, A., Cimatu, K., David, A., Farnoud, A. (2017). Engineered silica nanoparticles interact differently with lipid monolayers compared to lipid bilayers (Front Cover Feature). 5: 289-303.
  • Przybyla, R., Jason, W., Rajan, P., Saeed, N., Kaya, S., Farnoud, A. (2017). Electronic Cigarette Vapor Alters the Lateral Structure But Not Tensiometric Properties of Calf Lung Surfactant. 1. 18: 193-206.
  • Raj, S., Nazemidashtarjandi, S., Kim, J., Joffe, L., Zhang, X., Singh, A., Mor, V., Desmarini, D., Djordjevic, J., Raleigh, D., Rodrigues, M., London, E., Del Poeta, M., Farnoud, A. (2017). Changes in glucosylceramide structure affect virulence and membrane biophysical properties of Cryptococcus neoformans. 11. 1859: 2224–2233.
  • Mor, V., Farnoud, A., Singh, A., Rella, A., Tanno, H., Ishii, K., Kawakami, K., Sato, T., Del Poeta, M. (2016). Glucosylceramide administration as a vaccination strategy in mouse models of cryptococcosis. 4. 11: e0153853.
  • Mor, V., Rella, A., Farnoud, A., Singh, A., Munshi, M., Bryan, A., Nasseem, S., Konopka, J., Ojima, I., Bullesbach, E., Del Poeta, M. (2015). Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids. 3. 6: e00647-15.
  • Rella, A., Mor, V., Farnoud, A., Singh, A., Shamseddine, A., Ivanova, E., Carpino, N., Montagna, M., Luberto, C., Del Poeta, M. (2015). Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development. 6: 836-847.
  • Farnoud, A., Bryan, A., Kechichian, T., Luberto, C., Del Poeta, M. (2015). The granuloma response controlling cryptococcosis in mice depends on the SK1-S1P pathway.. 7. 83 : 2705-2713.
  • Rella, A., Farnoud, A., Del Poeta, M. (2015). Plasma membrane lipids and their role in fungal virulence. 61: 63-72.
  • Farnoud, A., Fiegel, J. (2014). Calf lung surfactant recovers surface functionality after exposure to aerosols containing polymeric particles.. In Press.
  • Farnoud, A., Mor, V., Singh, A., Del Poeta, M. (2014). Inositol phosphosphingolipid phospholipase C1 regulates plasma membrane ATPase (Pma1) stability in Cryptococcus neoformans. 558: 3932-3938.
  • Bryan, A., Farnoud, A., Mor, V., Del Poeta, M. (2014). Macrophage cholesterol depletion and its effect on the phagocytosis of Cryptococcus neoformans. 94: e52432.
  • Farnoud, A., Fiegel, J. (2013). Interaction of dipalmitoyl phosphatidylcholine monolayers with a particle-laden subphase.. 117: 12124-12134.
  • Oldham, E., Xie, W., Farnoud, A., Fiegel, J., Lehmler, H. (2012). Disruption of phosphatidylcholine monolayers and bilayers by perfluorobutanesulfonate. 33. 116: 9999-10007.
  • Farnoud, A., Fiegel, J. (2012). Low concentrations of negatively charged sub-micron particles alter the microstructure of DPPC at the air-water interface. 320-327. 415.
  • Yeganeh Sarkandy, S., Shojaosadati, S., Khalilzadeh, R., Sadeghyzade, M., Farnoud, A., Babaeipour, V., Maghsoudi, A. (2010). A novel amino acid supplementation strategy based on a stoichiometric model to enhance human interleukin-2 expression in high cell density E. coli cultures.. 57: 151-156.
  • Babaeipour, V., Shojaosadati, S., Khalilzadeh, R., Maghsoudi, N., Farnoud, A. (2010). Enhancement of human γ-interferon production in recombinant E. coli using batch cultivation. 8. 160: 2366-2386.
  • Yeganeh Sarkandy, S., Farnoud, A., Shojaosadati, S., Khalilzade, R., Ranjbar, B., Babaeipour, V. (2009). Overproduction of human interleukin-2 in recombinant E. coli BL21 high cell density culture by determination and optimization of essential amino acids using a simple stoichiometric model. 54: 31-39.
  • Shojaosadati, S., Varedi-Kolaei, S., Babaeipour, V., Farnoud, A. (2008). Recent advances in high cell density cultivation for production of recombinant protein. 2. Tehran: 6: 63-84.

Book, Chapter in Scholarly Book (1)

  • Farnoud, A., Toledo, A., Konopka, J., Del Poeta, M., London, E. (2015). Raft-like membrane domains in pathogenic microorganisms. Current Topics in Membranes; 75: 233-268.

Patents

  • Farnoud, A. Assays and methods for screening for chronic myeloid leukemia using engineered nanomaterials.. 60563-US-PSP/OU-19002.