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Douglas Goetz

Professor, Chemical and Biomolecular Engineering
Chemical and Biomolecular Engineering, Biomedical Engineering
Stocker Center 163
Phone: 740.593.1494

Before joining Ohio University in 1999, Dr. Goetz taught biomedical engineering at the University of Memphis. He served as a post-doctoral research fellow at Harvard Medical School and Brigham and Women's Hospital in Boston, and as a process engineer with Eli Lilly and Company.

Research Interests: Biomedical Engineering, Drug Delivery, Cell Adhesion, Biochemistry

All Degrees Earned: Ph.D. Cornell University

Conference Proceeding (7)

  • Bhatt, P., Lewis, C., House, D., Goetz, D., Malgor, R. (2010). Upregulation of Wnt5a transcripts in human monocytes treated with ox-LDL. Conference abstracts for the 2010 Biomedical Engineering Society Annual Meeting.
  • Malgor, R., Lewis, C., Keller, C., Kohn, L., Silver, M., Goetz, D. (2010). Wnt5a expression in human atherosclerotic plaques is elevated in macrophage-rich and complicated plaques. 2. ATHEROSCLEROSIS SUPPLEMENTS; 11: 135-135.
  • Tees, D., Sundd, P., Choi, Y., Goetz, D., Pai, A., Rogers, S. (2010). Neutrophil motion, adhesion and activation in an in vitro micropipette model of a lung capillary. Proceedings of the 3rd Joint US-European Fluids Engineering Summer Meeting and 8th International Conference on Nanochannels, Microchannels and Minichannels, August 1-5, 2010, Montreal, Canada: American Society of Mechanical Engineers; FEDSM-ICNMM2010-30177: 1-11.
  • Sundd, P., Choi, Y., Goetz, D., Tees, D. (2008). Neutrophil motion on P-selectin/ICAM-1 in an in vitro model of a lung capillary. State College, PA: Biorheology; 45: 126-126.
  • Sakhalkar, H., Dalal, M., Salem, A., Ansari, R., Fu, J., Kiani, M., Kurjiaka, D., Hanes, J., Shakesheff, K., Goetz, D. (2003). Leukocyte-Inspired Biodegradable Particles that Selectively and Avidly Adhere to Inflamed Endothelium In Vitro and In Vivo. Proceedings of the National Academy of Sciences; 100: 15985-15900.
  • Young, V., Ridgway, D., Prudich, M., Goetz, D., Stuart, B. (2001). Criterion-Based Grading for Learing and Assessment in Unit Operations Laboratory. Albuquerque, NM: 2001 ASEE Annual Conference.
  • Young, V., Ridgway, D., Prudich, M., Goetz, D., Stuart, B. (2001). Criterion-Based Grading for Learning and Assessment in Unit Operations Laboratory. Albuquerque, NM: Session 3213, American Society for Engineering Education 2001 National Meeting.

Journal Article, Academic Journal (44)

  • Noori, M., O'Brien, J., Champa, Z., Deosarkar, S., Lanier, O., Qi, C., Burdick, M., Schwartz, F., Bergmeier, S., McCall, K., Goetz, D. (2017). Phenylmethimazole and a Thiazole Derivative of Phenylmethimazole Inhibit IL-6 Expression by Triple Negative Breast Cancer Cells. European Journal of Pharmacology; 803: 130-137.
  • Carlson, G., Martin, E., Shirure, V., Malgor, R., Resto, V., Goetz, D., Burdick, M. (2017). Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. 3. PLoS ONE; 12: e0173747.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple Modifications to Methimazole that Enhance its Inhibitory Effect on Tumor Necrosis Factor-alpha-Induced Vascular Cell Adhesion Molecule-1 Expression by Human Endothelial Cells. European Journal of Pharmacology; 751: 59-66.
  • Shirure, V., Liu, T., Delgadillo, L., Cuckler, C., Tees, D., Benencia, F., Goetz, D., Burdick, M. (2015). CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions. 1. American Journal of Physiology-Cell Physiology; 308: C68-78.
  • Deosarkar, S., Bhatt, P., Gillespie, J., Goetz, D., McCall, K. (2014). Inhibition of LPS-Induced TLR4 Signaling Products in Murine Macrophages by Phenylmethimazole: An Assay Methodology for Screening Potential Phenylmethimazole Analogs. Drug Development Research; 75: 497-509.
  • Malgor, R., Bhatt, P., Connelly, B., Jacoby, D., Feldman, K., Silver, M., Nakazawa, M., McCall, K., Goetz, D. (2014). Wnt5a, TLR2 and TLR4 are Elevated in Advanced Human Atherosclerotic Lesions. Inflammation Research; 63: 277-285.
  • Bhatt, P., Lewis, C., House, D., Keller, C., Kohn, L., Silver, M., McCall, K., Goetz, D., Malgor, R. (2012). Increased Wnt5a mRNA Expression in Advanced Atherossclerotic Lesions, and Oxidized LDL Treated Human Monocyte-Derived Macrophages. 1. The Open Circulation and Vascular Journal; 5: 1-7.
  • Courreges, C., Kantake, N., Goetz, D., Frank, S., Kelly, M. (2012). Phenylmethimazole Blocks dsRNA-induced IRF3 Nucelar Translocation and Homodimerization. 10. Molecules; 17: 12365-12377.
  • Kummitha, C., Shirure, V., Delgadillo, L., Deosarkar, S., Tees, D., Burdick, M., Goetz, D. (2012). HECA-452 is a non-function blocking antibody for sialyl lewisx microsphere adhesion to endothelial expressed E-selectin under flow conditions. 1-2. Journal of Immunological Methods; 384: 43-50.
  • Burdick, M., Henson, K., Delgadillo, L., Choi, Y., Goetz, D., Tees, D., Benencia, F. (2012). Expression of E-selectin ligands on circulating tumor cells: Cross-regulation with cancer stem cell regulatory pathways?. Frontiers In Oncology; 2: 103 (11 pages).
  • Kummitha, C., Shirure, V., Delgadillo, L., Deosarkar, S., Tees, D., Burdick, M., Goetz, D. (2012). HECA-452 is a Non-Function Blocking Antibody for Sialyl Lewis-x Microsphere Adhesion to Endothelial Expressed E-selectin Under Flow Conditions. 1-2. Journal of Immunological Methods; 384: 43-50.
  • Deosarkar, S., Bhatt, P., Lewis, C., Goetz, D. (2011). Detection of Inflamed Endothelial Cells in Whole Blood Using Quantitative Real-Time PCR: A Potential Diagnostic/Prognostic Assay for Atherosclerosis.. 10. Annals of Biomedical Engineering; 39: 2627-2636.
  • Bhatt, P., Lewis, C., House, D., Goetz, D., Malgor, R. (2011). Oxidized LDL increases Wnt5a mRNA expression in human monocyte-derived macrophages.
  • Narayanaswamy, N., Faik, A., Goetz, D., Gu, T. (2011). Supercritical Carbon Dioxide Pretreatment of Corn Stover and Switchgrass for Lignocellulosic Ethanol Production. Bioresource Technology ; 102: 6995-7000.
  • Kummitha, C., Mayle, K., Christman, M., Deosarkar, S., Schwartz, A., McCall, K., Kohn, L., Malgor, R., Goetz, D. (2010). A sandwich ELISA for the Detection of Wnt5a. 1-2. Journal of Immunological Methods; 352: 38-44.
  • Benavides, U., Gonzalez-Murguiondo, M., Harii, N., Lewis, C., Sakhalkar, H., Deosarkar, S., Kurjiaka, D., Dagia, N., Goetz, D., Kohn, L. (2010). Phenyl methimazole suppresses dextran sulfate sodium-induced murine colitis. 1. European Journal of Pharmacology; 643: 129-138.
  • Schwartz, A., Malgor, R., Dickerson, E., Weeraratna, A., Slominski, A., Wortsman, J., Hari, N., Kohn, A., Moon, R., Schwartz, F., Goetz, D., Kohn, L., McCall, K. (2009). Phenylmethimazole Decreases Toll-Like Receptor 3 and Noncanonical Wnt5a Expression in Pancreatic Cancer and Melanoma Together with Tumor Cell Growth and Migration. Clin Cancer Res.
  • Sundd, P., Zou, X., Goetz, D., Tees, D. (2008). Leukocyte Adhesion in Capillary-Sized, P-selectin Coated Micropipettes. 2. Microcir.; 15: 109-22.
  • Deosarkar, S., Malgor, R., Fu, J., Kohn, L., Hanes, J., Goetz, D. (2008). Polymeric Particles Conjugated with a Ligand to VCAM-1 Exhibit Selective, Avid and Focal Adhesion to Sites of Atherosclerosis. 2. Biotech. and Bioeng.; 101: 400-7.
  • Christman, M., Goetz, D., Dickerson, E., McCall, K., Lewis, C., Benencia, F., Silver, M., Kohn, L., Malgor, R. (2008). Wnt5a is Expressed in Murine and Human Atherosclerotic Lesions. 6. Am. J. Phy. Heart Circ. Phys.; 294: H2864-70.
  • Hamm, A., Goetz, D., Klibanov, A., Lawrence, M. (2007). Microparticle Adhesive Dynamics and Rolling Mediated by Selectin Specific Antibodies under Flow. 3. Biotech. and Bioeng.; 96: 596-607.
  • Sakhalkar, H., Hanes, J., Fu, J., Benavides, U., Malgor, R., Borruso, C., Kohn, L., Kurjiaka, D., Goetz, D. (2005). Enhanced Adhesion of Ligand-Conjugated Biodegradable Particles to Colitic Venules. FASEB J.; 19: 792-794.
  • Zou, X., Shinde Patil, V., Dagia, N., Smith, L., Wargo, M., Interliggi, K., Lloyd, C., Tees, D., Walcheck, B., Lawrence, M., Goetz, D. (2005). PSGL-1 Derived from Human Neutrophils is a High Efficiency Ligand for Endothelial Expressed E-selectin under Flow. Am. J. Phys. – Cell Phys.; 289: C415-424.
  • Yuan, H., Goetz, D., Gaber, M., Issekutz, A., Merchant, T., Kiani, M. (2005). Radiation-Induced Up-regulation of Adhesion Molecules in Brain Microvasculature and their Modulation by Dexamethasone. Radiat Res.; 163: 544-51.
  • Harii, N., Lewis, C., Vasko, V., McCall, K., Benavides-Peralta, U., Ringel, M., Saji, M., Giuliani, C., Napolitano, G., Goetz, D., Kohn, L. (2005). Thyrocytes Express a Functional Toll-like receptor 3 (TLR3): Overexpression Can Be Induced by Viral Infection, Reversed by Pheylmethimazole, and Is Associated with Hashimoto’s Autoimmune Thyroiditis. Mol. Endo.; 19: 1231-1250.
  • Kohn, L., Schwartz, F., Silver, M., Goetz, D. (2005). Toll-like Receptors in Nonimmune Cells and Environmental Induction of the Pathologic Expression of Innate Immunity and Autoimmune Inflammatory Diseases: A New Therapeutic Opportunity. Spring; 3-11.
  • Yun, Y., Goetz, D., Yellen, P., Chen, W. (2004). Hyaluronan Microspheres for Sustained Gene Delivery and Site Specific Targeting. Biomaterials; 25: 147-157.
  • Dagia, N., Harii, N., Meli, A., Sun, X., Lewis, C., Kohn, L., Goetz, D. (2004). Phenyl Methimazole Inhibits TNF-α-Induced VCAM-1 Expression in an IFN Regulatory Factor-1-Dependent Manner and Reduces Monocytic Cell Adhesion to Endothelial Cells. J. Immunol.; 173: 2041-2049.
  • Dagia, N., Goetz, D. (2003). A Proteasome Inhibitor Reduces Concurrent, Sequential and Long-term IL-1 and TNF-α-induced ECAM Expression and Adhesion. Am J. Physiol.; 285: C813-C822.
  • Tees, D., Goetz, D. (2003). Leukocyte Adhesion: An Exquisite Balance of Hydrodynamic and Molecular Forces. News in Physiological Sciences; 18: 186-190.
  • Kiani, M., Yuan, H., Chen, X., Smith, L., Gaber, M., Goetz, D. (2002). Targeting Microparticles to Select Tissues via Radiation-Induced Upregulation of Endothelial Cell Adhesion Molecules. Pharm. Res.; 19: 1317-1322.
  • Burch, E., Shinde Patil, V., Camphausen, R., Kiani, M., Goetz, D. (2002). The N-terminal Peptide of PSGL-1 Can Mediate Adhesion to Trauma-Activated Endothelium via P-selectin in Vivo. Blood; 100: 531-538.
  • Prabhakarpandian, B., Goetz, D., Swerlick, R., Chen, X., Kiani, M. (2001). Expression and Functional Significance of Adhesion Molecules on Cultured Endothelial Cells in Response to Ionizing Radiation. 5. Microcirc.; 8: 355-364.
  • Blackwell, J., Dagia, N., Dickerson, J., Berg, E., Goetz, D. (2001). Ligand Coated Nanosphere Adhesion to E- and P-selectin under Static and Flow Conditions. 6. Annals of Biomedical Engineering; 29: 523-533.
  • Dickerson, J., Blackwell, J., Ou, J., Shinde Patil, V., Goetz, D. (2001). Limited Adhesion of Biodegradable Microspheres to E- and P-selectin under Flow. Biotechnology and Bioengineering; 73: 500-509.
  • Shinde Patil, V., Campbell, C., Yuan, Y., Slack, S., Goetz, D. (2001). Particle Diameter Influences Adhesion Under Flow. Biophys J.; 80: 1733-1743.
  • Crutchfield, K., Shinde Patil, V., Campbell, C., Parkos, C., Allport, J., Goetz, D. (2000). CD11b/CD18-coated microspheres attach to E-selectin under Flow. J. Leuk. Biol.; 67: 196-205.
  • Lim, Y., Wakelin, M., Henault, L., Goetz, D., Yednock, T., Cabanas, C., Sanchez-Madrid, F., Lichtman, A., Luscinskas, F. (2000). 41 Integrin Activation is Necessary for High Efficiency T Cell Subset Interactions with VCAM-1 under Flow. Microcirc.; 7: 201-214.
  • Goetz, D., Greif, D., Ding, H., Camphausen, R., Howes, S., Comess, K., Snapp, K., Kansas, G., Luscinskas, F. (1997). Isolated P-selectin Glycoprotein Ligand-1 Dynamic Adhesion to P- and E-selectin. J. Cell Biol.; 137: 509-519.
  • Goetz, D., Ding, H., Atkinson, W., Vachino, G., Camphausen, R., Cumming, D., Luscinskas, F. (1996). A Human Colon Carcinoma Cell Line Exhibits Adhesive Interactions with P-selectin under Fluid Flow via a PSGL-1 Independent Mechanism. Am. J. Path; 149: 1661-1673.
  • Goetz, D., Brandley, B., Hammer, D. (1996). An E-selectin-IgG Chimera Supports Sialylated Moiety Dependent Adhesion of Human Carcinoma Cells under Fluid Flow. Annals of Biomed. Eng.; 24: 87-98.
  • Goetz, D., El-Sabban, M., Hammer, D., Pauli, B. (1996). Lu-ECAM-1 Mediated Adhesion of Melanoma Cells to Endothelium under Conditions of Flow. Int. J. Cancer; 65: 192-199.
  • Brunk, D., Goetz, D., Hammer, D. (1996). Sialyl-Lewisx/E-selectin-Mediated Rolling in a Cell-Free System. Biophys. J.; 71: 2902-2908.
  • Goetz, D., El-Sabban, M., Pauli, B., Hammer, D. (1994). Dynamics of Neutrophil Rolling Over Stimulated Endothelium in Vitro. Biophys. J.; 66: 2202-2209.

Book, Chapter in Scholarly Book (3)

  • Tees, D., Sundd, P., Goetz, D. (2006). "A Flow Chamber for Capillary Networks: Leukocyte Adhesion in Capillary-Sized Ligand-Coated Micropipettes" in Principles of Cellular Engineering: Understanding the Biomolecular Interface. New York: M.R. King; 213-231.
  • Goetz, D., Greif, D., Shen, J., Luscinskas, F. (1999). "Cell-Cell Adhesive Interactions in an In Vitro Flow Chamber" in Adhesion Protein Protocols. Humana Press; 137-145.
  • Hammer, D., Tempelman, L., Goetz, D. (1994). "Kinetics and Mechanics of Cell Adhesion under Hydrodynamic Flow: Two Cell Systems" in Cellular Mechanics and Cellular Engineering. New York: Springer-Verlag Inc.; 121-144.


  • Goetz, D., McCall, K., Schwartz, F., Malgor, R. Prevention and treatment of non-alcoholic fatty liver disease . 9,750,723.
  • McMills, M., Goetz, D., Bergmeier, S., Orac, C. Imidazole and Thiazole Compositions for Modifying Biological Signaling. 15/326,821.
  • Goetz, D., Kohn, L., Harri, N., Benavides-Peralta, U., Gonzalez-Murguiondo, M., Lewis, C., Napolitano, G., Giuliani, C., Malgor, R., Schwartz, F., McCall, K. Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression (Broadens 9,326972).
  • Goetz, D., Bergmeier, S., McMills, M., Orac, C., McCall, K., Schwartz, F. Imidazole and thiazole compositions for modifying biological signaling.
  • Goetz, D., Bergmeier, S., McCall, K., Schwartz, F., Deosarkar, S., Bhatt, P. Methods and compositions to modify GSK-3 activity.
  • Goetz, D., Bergmeier, S., McCall, K., Schwartz, F. Prevention and treatment of non-alcoholic fatty liver disease (new compounds).
  • Bergmeier, S., Goetz, D., McMall, K. A method to modify the activity of GSK-3.
  • Bergmeier, S., Goetz, D., McMall, K. Use of phenylmethyimazole for the prevention and treatment of fatty liver disease.
  • Bergmeier, S., Goetz, D., McMills, M., McMall, K. Compositions that modify biological signaling.
  • Goetz, D., Kohn, L., Benavides-Peralta, U., Gonzalez-Murguiondo, M., Harii, N., Lewis, C., Napolitano, G., Dagia, N. Methods for the Amelioration of Episodes of Acute and Chronic Ulcerative Colitis. 7,928,132.
  • Burdick, M., Goetz, D., Malgor, R., Shirure, V., Resto, V. Dynamic biochemical tissue analysis. WO/2013/006405 .