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Monica Burdick

Monica Burdick
Associate Professor
Stocker Center 189
Biomedical Engineering

Dr. Burdick earned her Ph.D. in Chemical and Biomolecular Engineering from Johns Hopkins in 2003, and her B.S. in Chemical Engineering from the University of Rochester, where she minored in chemistry and economics and earned a certificate in biomedical engineering. Following her Ph.D., she became a post-doctoral research fellow at the Harvard Medical School and Brigham and Women's Hospital in Boston, MA. In her research, Dr. Burdick applies engineering principles such as fluid dynamics to study how cancer cells move through the body, and how metastasis can be countered.

Research Interests: Colon Cancer, Breast Cancer, Metastatis, Cell Adhesion

All Degrees Earned: Ph.D., Chemical and Biomolecular Engineering, Johns Hopkins, 2003 -- BS, Chemical Engineering, University of Rochester, 1998

Journal Article, Academic Journal (37)

  • Nazemidashtarjandi, S., Sharma, V., Puri, V., Farnoud, A., Burdick, M. (2022). Lipid Composition of the Cell Membrane Outer Leaflet Regulates Endocytosis of Nanomaterials through Alterations in Scavenger Receptor Activity. ACS Nano.
  • Kauffman, M., Allen, A., Reynolds, N., Ghazanfari, D., Nazemidashtarjandi, S., Faik, A., Burdick, M., McCall, K., Goetz, D. (2020). Evidence that Knock Down of GSK-3b in Haploid Chronic Myelogenous Leukemia Cells Augments IFN-g Induced Apoptosis and Necrosis. Leukemia Research.
  • Kauffman, M., Nazemidashtarjandi, S., Ghazanfari, D., Allen, A., Reynolds, N., Faik, A., Burdick, M., McCall, K., Goetz, D. (2020). Evidence that knock down of GSK-3β in Chronic Myelogenous Leukemia cells augments IFN-γ-induced apoptosis.. Leukemia Research; 99: 106464.
  • Kheradmandi, M., Ackers, I., Burdick, M., Malgor, R., Farnoud, A. (2020). Targeting dysfunctional vascular endothelial cells using immunoliposomes under flow conditions. Cellular and Molecular Bioengineering; 13: 189-199.
  • Mohammadalipour, A., Showalter, C., Muturi, H., Farnoud, A., Najjar, S., Burdick, M. (2020). Cholesterol depletion decreases adhesion of non-small lung cancer cells to E-selectin. Am J Phys - Cell Physiol.
  • Noori, M., Bodle, S., Showalter, C., Streator, E., Drozek, D., Burdick, M., Goetz, D. (2020). Sticking to the Problem: Engineering Adhesion in Molecular Endoscopic Imaging.. 2. Cellular and molecular bioengineering; 13: 113-124.
  • Martin, E., Malgor, R., Resto, V., Goetz, D., Burdick, M. (2019). Dynamic biochemical tissue analysis detects functional selectin ligands on cancer tissues. 1. 9: 8511.
  • Goldson, T., Turner, K., Huang, Y., Carlson, G., Caggiano, E., Oberhauser, A., Fennewald, S., Burdick, M., Resto, V. (2019). Nucleolin Mediates the Binding of Cancer Cells to L-selectin under Conditions of Lymphodynamic Shear Stress. American Journal of Physiology - Cell Physiology.
  • Noori, M., Streator, E., Carlson, G., Drozek, D., Burdick, M., Goetz, D. (2018). An adhesion based approach for the detection of esophageal cancer.. 12. Integrative Biology; 10: 747-757.
  • Mohammadalipour, A., Burdick, M., Tees, D. (2018). Deformability of breast cancer cells in correlation with surface markers and cell rolling. 4. FASEB Journal; 32: 1806-1817. .
  • Reynolds, N., Mohammadalipour, A., Hall, C., Asghari Adib, A., Farnoud, A., Burdick, M. (2018). Galectin-1 Influences Breast Cancer Cell Adhesion to E-selectin via Ligand Intermediaries. 1. Cellular and Molecular Bioengineering; 11: 37-52.
  • Mohammadalipour, A., Burdick, M., Tees, D. (2017). Viscoelasticity measurements reveal rheological differences between stem-like and non-stem-like breast cancer cells. 3. Cellular and Molecular Bioengineering; 10: 235-248.
  • Noori, M., O'Brien, J., Champa, Z., Deosarkar, S., Lanier, O., Qi, C., Burdick, M., Schwartz, F., Bergmeier, S., McCall, K., Goetz, D. (2017). Phenylmethimazole and a Thiazole Derivative of Phenylmethimazole Inhibit IL-6 Expression by Triple Negative Breast Cancer Cells. European Journal of Pharmacology; 803: 130-137.
  • Carlson, G., Martin, E., Shirure, V., Malgor, R., Resto, V., Goetz, D., Burdick, M. (2017). Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. 3. PLoS ONE; 12: e0173747.
  • Yuan, Y., Wu, L., Shen, S., Wu, S., Burdick, M. (2016). Effect of alpha 2, 6 Sialylation on Integrin-mediated Adhesion of Breast Cancer Cells to Fibronectin and Collagen IV. 149. Life Sciences; 138-145.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple Modifications to Methimazole that Enhance its Inhibitory Effect on Tumor Necrosis Factor-alpha-Induced Vascular Cell Adhesion Molecule-1 Expression by Human Endothelial Cells. European Journal of Pharmacology; 751: 59-66.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple modifications to methimazole that enhance its inhibitory effect on tumor necrosis factor-α-induced vascular cell adhesion molecule-1 expression by human endothelial cells.. European journal of pharmacology; 751: 59-66.
  • Shirure, V., Liu, T., Delgadillo, L., Cuckler, C., Tees, D., Benencia, F., Goetz, D., Burdick, M. (2015). CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions. 1. American Journal of Physiology-Cell Physiology; 308: C68-78.
  • Burdick, M., Reynolds, N., Martin, E., Hawes, J., Carlson, G., Cuckler, C., Bates, M., Barthel, S., Dimitroff, C. (2014). Isolation and characterization of chimeric human Fc-expressing proteins using protein A membrane adsorbers and a streamlined workflow. 83. Cambridge, MA: Journal of Visualized Experiments.
  • Carlson, G., Martin, E., Burdick, M. (2013). Simultaneously capturing real-time images in two emission channels using a dual camera emission splitting system: Applications to cell adhesion. 79. Cambridge, MA: Journal of Visualized Experiments; 4: e50604.
  • Barthel, S., Hays, D., Yazawa, E., Opperman, M., Walley, K., Nimrichter, L., Burdick, M., Gillard, B., Siddiqui , J., Foster, B., Moser, M., Pantel, K., Pienta, K., Charles, D. (2013). Molecular determinants of prostate cancer cell bone extravasation: E-selectin ligands, integrins and GTPases. 2. Cancer Research; 73: 942-952.
  • Shirure, V., Reynolds, N., Burdick, M. (2012). Mac-2 Binding Protein is a Novel Eselectin Ligand Expressed by Breast Cancer Cells. 9. PLoS ONE; 7: e44529 (11 pages).
  • Burdick, M., Henson, K., Delgadillo, L., Choi, Y., Goetz, D., Tees, D., Benencia, F. (2012). Expression of E-selectin ligands on circulating tumor cells: Cross-regulation with cancer stem cell regulatory pathways?. Frontiers In Oncology; 2: 103 (11 pages).
  • Kummitha, C., Shirure, V., Delgadillo, L., Deosarkar, S., Tees, D., Burdick, M., Goetz, D. (2012). HECA-452 is a Non-Function Blocking Antibody for Sialyl Lewis-x Microsphere Adhesion to Endothelial Expressed E-selectin Under Flow Conditions. 1-2. Journal of Immunological Methods; 384: 43-50.
  • Merzaban, J., Burdick, M., Gadhoum, S., Dagia, N., Chu, J., Fuhlbrigge, R., Sackstein, R. (2011). Analysis of Glycoprotein E-selectin Ligands on Human and Mouse Marrow Cells Enriched for Hematopoietic Stem/Progenitor Cells. 7. 118: 1174-83.
  • Shirure, V., Henson, K., Schnaar, R., Nimrichter, L., Burdick, M. (2011). Glycolipids are Major E-selectin Ligands Expressed by Breast Cancer Cells. 3. Biochemical and Biophysical Research Communications; 406: 423-9.
  • Wang, L., Shirure, V., Burdick, M., Wu, S. (2011). UVB-Irradiation Regulates VLA-4-Mediated Melanoma Cell Adhesion To Endothelial VCAM-1 Under Flow Conditions. 1. Mol. Carcinogenesis; 50: 58-65.
  • Nimrichter, L., Burdick, M., Aoki, K., Laroy, W., Fierro, M., Hudson, S., Von Seggern, C., Cotter, R., Bochner, B., Tiemeyer, M., Konstantopoulos, K., Schnaar, R. (2008). E-selectin receptors on human leukocytes. 9. Blood; 112: 3744-3752.
  • Resto, V., Burdick, M., Dagia, N., McCammon, S., Fennewald, S., Sackstein, R. (2008). L-selectin-mediated lymphocyte-cancer cell interactions under low fluid shear conditions. 23. Journal of Biological Chemistry; 283: 15816-15824.
  • Burdick, M., Alves, C., Thomas, S., Pawar, P., Konstantopoulos, K. (2008). The Dual Role of CD44 as a Functional P-selectin and Fibrin Ligand in Colon Carcinoma Cell Adhesion. 4. American Journal of Physiology- Cell Physiology; 294: C907-C916.
  • Burdick, M., Chu, J., Godar, S., Sackstein, R. (2006). HCELL is the Major E- and L-Selectin Ligand Expressed on LS174T Colon Carcinoma Cells. Journal of Biological Chemistry; 281: 13899-13905.
  • Burdick, M., Lim, L., Hudson, S., Konstantopoulos, K., Bochner, B. (2006). Stimulation of Human Endothelium with IL-3 Induces Selective Basophil Accumulation In Vitro. Journal of Immunology; 176: 5346-5353.
  • Hanley, W., Napier, S., Burdick, M., Schnaar, R., Sackstein, R., Konstantopoulos, K. (2006). Variant Isoforms of CD44 are P- and L-selectin Ligands on Colon Carcinoma Cells. Federation of American Societies for Experimental Biology (FASEB) Journal; 20: 337-339.
  • Burdick, M., Konstantopoulos, K. (2004). Platelet-Induced Enhancement of Colon Carcinoma Cell Adhesion to Vascular Endothelium under Flow. 2. American Journal of Physiology- Cell Physiology; 287: C539-C547.
  • Burdick, M., McCaffery, J., Kim, Y., Bochner, B., Konstantopoulos, K. (2003). Colon Carcinoma Cell Glycolipids, Integrins and Other Glycoproteins Mediate Adhesion to HUVECs under Flow. 4. American Journal of Physiology- Cell Physiology; 284: C977-C987.
  • McCarty, O., Jadhav, S., Burdick, M., Bell, W., Konstantopoulos, K. (2002). Fluid Shear Regulates the Kinetics and Molecular Mechanisms of Activation-Dependent Platelet Binding to Colon Carcinoma Cells. 2. Biophysical Journal; 83: 836-848.
  • Tachimoto, H., Burdick, M., Hudson, S., Konstantopoulos, K., Bochner, B. (2000). Chemokines Promote Rapid Detachment of Eosinophils from VCAM-1 In Vitro. Journal of Immunology; 165: 2748-2754.

Patent (1)

  • Burdick, M., Goetz, D., Malgor, R., Shirure, V., Resto, V. Dynamic biochemical tissue analysis. WO/2013/006405 .

Conference Proceeding (1)

  • Burdick, M., McCarty, O., Jadhav, S., Konstantopoulos, K. (2001). Cell-Cell Interactions in Inflammation and Cancer Metastasis. 3. IEEE Engineering in Medicine and Biology; 20: 86-91.

Research Report (2)

  • Burdick, M., Hanley, W., Konstantopoulos, K., Sackstein, R. (2005). CD44 on LS174T Colon Carcinoma Cells Possesses E-selectin Ligand Activity. 13. Cancer Research; 65: 5812-5817.
  • Burdick, M., Schnaar, R., Collins, B., Bochner, B., Konstantopoulos, K. (2001). Glycolipids Support E-selectin-Specific Strong Cell Tethering under Flow. Biochemical and Biophysical Research Communications ; 284: 42-49.