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A Diabetes-Free Society

Member Profile

Frank  Schwartz, MD, FACE

Professor, Endocrinology

HCOM-Specialty Medicine

Academic Research Center 331


Member Type: Investigator 

Research Interest

 My research is focused on:

  • The role of pathologic expression and signaling of Toll-Like Receptors (TLR) in the pathogenesis of both type I and type II Diabetes, obesity and atherosclerosis.  We are developing a novel compound (methylmethimazole or C10) which suppresses the TLR signaling pathways and inflammatory cytokines which contribute to the pathogenesis of viral-induced Type I and obesity-induced Type II diabetes making it a potential therapeutic for these and other immune-inflammatory diseases.
  • The role of socioeconomic stress and lack of functional social networks on the prevalence of obesity, insulin resistance, and diabetes-associated complications which contribute to the high prevalence of premature morbidity  and mortality for ASCVD, chronic kidney disease, blindness, and amputation seen in Appalachia, impact of depression on diabetes outcomes, as well as the barriers to adequate and preventative diabetes care in Appalachia
  • Development of Artificial Intelligence (AI) and case-based reasoning software scan large volumes of patient glucose monitoring data, observe recurrent abnormal glucose patterns and then provide intelligent decision support for physicians caring for patients with type I diabetes on insulin pump therapy

Selected Publications

  • Marling, C., Bunescu, R., Shubrook, J. and F. Schwartz (2012). System Overview: The 4 Diabetes Support System, in Workshop Proceedings of the Twentieth International Conference on Case-Based Reasoning, Lyon, France. Ram, A. and N. Wiratunga, eds., Springer, Berlin.
  • Burkley AL, Brown K, Holben DH, Shubrook JH, Schwartz FL. Adult food security and social capital among patients using free and fee-for-service diabetes clinics in rural, Appalachian Ohio. J Am Diet Assoc. 2011; 111 (9) (Suppl 2):A100.
  • Brown KA, Burkley AL, Holben DH, Shubrook JH, Schwartz FL. Diabetes management and food access in individuals with diabetes using free and fee-for-service clinics in rural Appalachian Ohio. J Am Diet Assoc. 2011;111 (9) (Suppl 2):A101.
  • Merrill, J., de Groot, M., Shubrook, JH. , Doyle, T., Kushnick, M., Heckman, B.  & Schwartz, FL. Comorbid Pain in Adults with Type 2 Diabetes Enrolled in a Depression Treatment Program.  Annals of Behavioral Medicine, 41, (Supplement), S77 (2011).
  • Marling, C., Wiley, M., Cooper, T., Bunescu, R., Shubrook, J. and F. Schwartz (2011). "The 4 Diabetes Support System: A Case Study in CBR Research and Development," in Case-Based Reasoning Research and Development: 19th International Conference on Case-Based Reasoning, ICCBR 2011 Proceedings, Ram, A. and N. Wiratunga, eds., Springer, Berlin.
  • Wiley, M., Bunescu, R., Marling, C., Shubrook, J. and F. Schwartz (2011). "Automatic Detection of Excessive Glycemic Variability for Diabetes Management," in Proceedings of the Tenth International Conference on Machine Learning and Applications, IEEE Press, New York, New York.

For more publications please link to PubMed.

Awards and Honors


  • Outstanding Inventive Contributions to Ohio University Intellectual Property, 2004-2005
  • Ohio University Heritage College of Osteopathic Medicine Awards
    *Master Clinical Faculty Award, 1996
    *Outstanding Specialty Physician Award, 1998 & 2006
    *Outstanding  COM & CCE Preceptor
    *Sigma Sigma Phi DOC Awards, 2006, 08, 09,10
    *Outstanding Basic Science Presenter
    *Sigma Sigma Phi DOC Awards, 2006, 09, 10
    *Standard of Excellence Award, Ohio University College of Osteopathic Medicine, 2006
    *Clinical Faculty of the Year, 2008
    *Outstanding Clinical Science Faculty CPC II, 2009, 2010, 2011, 2012
    *Clinical Preceptor of the Year, PCC II, 2010
    *Outstanding Preceptor for Excellence in Cultural Competency Award, 2010

Related Links

OU Heritage College of Medicine
Diabetes Institute Investiator Highlight

Family Medicine Faculty Positions
Diabetes Registry