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Biomaterials Lab


Betty Sindelar, PT, PhD

Grover Center W294

About the Facility
The Biomaterials Lab at Ohio University is used in the study of tissue properties, tissue adaptations to loading, and structure/function interactions. A fume hood and wet lab areas are used to process tissues for histologic, morphologic, and immunohistochemical investigations. In particular, collagen and proteoglycan contents of tissues are prepared for assays, electrophoresis, staining and sectioning, and microscopic comparisons.

A Q-Test 10 from MTS Corporation is used to examine the material properties of tissues in compressive and tensile modes. Programs are utilized for viscoelastic material behavior (specifically creep and stress relaxation) as well as load to failure regimes in tension, compression, or bending. A variety of load cells allows for the testing of various size and compositions of structures. Recently the lab has been performing tensile tests of the TMJ capsule, both medial and lateral components. Material property tests are often done in conjunction with associates in other colleges here at OU and at other universities across the country.

In addition, the lab houses an EMG system for the in vivo collection of muscle signals. Fine wire electrodes are custom-made in the lab. Tissue samples are acquired from animal models, generally the pig. Most experiments are focused on the temporomandibular joint (TMJ) and its components.

Imaging studies continue to be another avenue of research. MRIs of TMJ structures are used to help to develop new treatment guidelines for patients with TMJ disc dysfunctions especially anterior disc derangement with reduction. Micro-CT scans are being used with pig TMJ bony structures to examine trabecular pattern and density changes relative to loading changes in vivo.

In addition, the lab has been working with Duane Keller, DMD, examining the effectiveness of a new technique, the Perio Protect MethodTM, for the treatment of periodontal disease.