Tadeusz Malinski

Recent News

Education

Ph.D. obtained from Poznan University of Technology

Research

• Nanomedicine
• Development of nanosensors, genetically encoded probes and imaging systems for cellular and subcellular analysis
• Application of nanosensors, imaging systems and probes for an early medical diagnosis and targeted therapy of cardiovascular and neurodegenerative diseases
• Nanobiotechnology
• Nanosensors and nanodevices for nanomedical applications
• Group Website

We are pursuing studies in three related areas. A major interest of the laboratory is to understand the regulatory role of nitric oxide, superoxide and peroxynitrate in the cardiovascular system. Dr. Malinski studies the events occurring at the level of the receptors and the signaling pathways regulating heart beat performance and blood flow in the arteries. A specially designed sensors (diameter less than one micrometer), implantable in a single cell or neurons are used for these studies. A pathology of the cardiovascular system (arteriosclerosis, diabetes, hypertension and aging) are studied and the approaches taken involve bioanalytical measurements, molecular biology as well as physiological monitoring in experimental models.

Another objective of the laboratory is to develop and to test novel strategies for drug and gene delivery and new strategies for organ preservation for transplants. We are interested in targeting specifically the cells of the vessel wall which are critical in the pathogenesis of arteriosclerosis, septic shock, cardiac dysfunction and cancer metastasis. The intent of this strategy is to prevent dysfunction of endothelium or to restore the function of damaged endothelium which is critical in the regulation of blood flow. Finally, this laboratory is studying intra-neuronal nitric oxide signaling in the brain. In particular, we are interested in the kinetics of nitric oxide release in the brain during ischemia/reperfusion and hypobaric hypoxia. These studies are also pursuing the role of the L-arginine/NO pathway in the pathology of brain function (Parkinson's and Alzheimer's diseases), molecular basis of nitric oxide action, and then to develop strategies for mollification of brain damaged caused by stroke, Parkinson's or Alzheimer's diseases.

Continued areas of interest include also development of new electrically conductive polymeric materials and new generation of lithium ion batteries for hybryde vehicles and nanobatteries for medial applications.

Courses Taught

• CHEM 7260 Electroanalytical Chemistry
• CHEM 5800 Advanced Analytical Chemistry

Selected Publications

1. Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics. Eroglu E, Gottschalk B, Charoensin S, Blass S, Bischof H, Rost R, Madreiter-Sokolowski CT, Pelzmann B, Bernhart E, Sattler W, Hallström S, Malinski T, Waldeck-Weiermair M, Graier WF, Malli R. Nature Commun. 2016 4;7:10623.

2. Amlodipine increased endothelial nitric oxide and decreased nitroxidative stress disproportionately to blood pressure changes. Mason RP, Jacob RF, Corbalan JJ, Kaliszan R, Malinski T. Am J Hypertens. 2014 27(3):482-8.

3. Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects. Corbalan JJ, Medina C, Jacoby A, Malinski T, Radomski MW. Int J Nanomedicine. 2011;6:2821-35

4. Effect of enhanced glycemic control with saxagliptin on endothelial nitric oxide release and CD40 levels in obese rats. Mason RP, Jacob RF, Kubant R, Walter MF, Bellamine A, Jacoby A, Mizuno Y, Malinski T. J Atheroscler Thromb. 2011;18(9):774-83.

5. Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces. Stern E, Jay SM, Demento SL, Murelli RP, Reed MA, Malinski T, Spiegel DA, Mooney DJ, Fahmy TM. Adv Funct Mater. 2009 13;19(18):2888-2895.

6. Ultraviolet B light-induced nitric oxide/peroxynitrite imbalance in keratinocytes--implications for apoptosis and necrosis. Wu S, Wang L, Jacoby AM, Jasinski K, Kubant R, Malinski T. Photochem Photobiol. 2010;86(2):389-96.

7. Leptin-induced endothelial dysfunction in obesity. Korda M, Kubant R, Patton S, Malinski T. Am J Physiol Heart Circ Physiol. 2008;295(4):H1514-21.

8. Effect of beta-blockers on endothelial function during biological aging: a nanotechnological approach. Funovic P, Korda M, Kubant R, Barlag RE, Jacob RF, Mason RP, Malinski T. J Cardiovasc Pharmacol. 2008;51(2):208-15

9. S-nitroso human serum albumin reduces ischaemia/reperfusion injury in the pig heart after unprotected warm ischaemia. Hallström S, Franz M, Gasser H, Vodrazka M, Semsroth S, Losert UM, Haisjackl M, Podesser BK, Malinski T. Cardiovasc Res. 2008;77(3):506-14

10. Electropolymerization on microelectrodes: functionalization technique for selective protein and DNA conjugation. Stern E, Jay S, Bertram J, Boese B, Kretzschmar I, Turner-Evans D, Dietz C, LaVan DA, Malinski T, Fahmy T, Reed MA. Anal Chem. 2006 78(18):6340-6.