Ph.D. in Molecular and Cellular Biology/Biological Sciences
I am a Ph.D. student investigating the influence of Notch signaling on the metastatic dissemination of breast cancer cells through the blood. Specifically, I study how Notch signaling alters the expression of E-selectin ligands on the surface of breast cancer cells.
To perform this study I utilize molecular methods (qRT-PCR, Western blotting, flow cytometry) in combination with analysis of flow chamber models that mimic physiological stresses of breast cancer cells traveling through the bloodstream. E-selectin ligands promote the attachment of metastatic breast cancer cells to distant sites for inducement of secondary tumor formation.
Consequently, understanding how these ligands are regulated in breast cancer may lead to the development of novel breast cancer drug therapies.