Research Interests: |
My research is aimed at understanding how maternal adversity and early life stress affects neurobehavioural outcomes in the mother and offspring. In particular we investigate how maternal depression, stress, and antidepressant medication exposure affects neuroplasticity in the hippocampus and key components of the hypothalamic-pituitary-adrenal axis. Current projects are investigating
- the effects of stress on neurogenesis and neuron morphology in the maternal brain,
- the effect of the antidepressant medications, such as Prozac, on hippocampal neurogenesis in the mother and offspring, and
- the effect of early life stress and antidepressant exposure on offspring reproductive behaviors.
B.Sc. Biopsychology (2000), University of British Columbia, Canada
M.A. Psychology (2003), Department of Psychology, Program in Neuroscience, University of Toronto, Canada
Ph.D. Neuroscience (2007), Program in Neuroscience, Department of Psychology, University of British Columbia, Canada
Postdoctoral Fellow (2007-2008), Interdisciplinary Women's Reproductive Health Strategic Training Program
Child & Family Research Institute, University of British Columbia, Canada
Postdoctoral Fellow (2008-2011), School of Mental Health and Neuroscience, Maastricht University, The Netherlands
Chargé de recherche (2010-2014), Fonds de la Recherche Scientifique (FRS-FNRS), Belgium
GIGA-Neurosciences, University of Liège, Belgium
- Rayen I, Steinbusch HW, Charlier TD, Pawluski JL. (2013). Developmental fluoxetine exposure and prenatal stress alter sexual differentiation of the brain and reproductive behavior in male rat offspring. Psychoneuroendocrinology doi:pii: S0306-4530(13)00012-7. 10.1016/j.psyneuen.2013.01.007. [Epub ahead of print]
- Pawluski JL, Rayen I, Niessen NA, Kristensen S, van Donkelaar EL, Balthazart J, Steinbusch HW, Charlier TD. (2012).Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspring. Neuroscience 220:131-41.
- Pawluski JL, Brain UM, Underhill CM, Hammond GL, Oberlander TF.Prenatal SSRI exposure alters neonatal corticosteroid binding globulin, infant cortisol levels, and emerging HPA function. (2012). Psychoneuroendocrinology 37(7):1019-28.
- Pawluski JL. (2012). Perinatal selective serotonin reuptake inhibitor exposure: impact on brain development and neural plasticity. Neuroendocrinology. 95(1):39-46.
- Pawluski JL, van den Hove DL, Rayen I, Prickaerts J, Steinbusch HW. (2011). Stress and the pregnant female: Impact on hippocampal cell proliferation, but not affective-like behaviors. Horm Behav. 59(4):572-80.