|• Email:||Christine Griffin|
|• Office:||062 Irvine Hall|
|• BIOS 3420:||Principles of Physiology Lab|
Research Interests: |
My dissertation research focused on the regulation of muscle stem cells by odorant receptors (ORs). Cellular and molecular biology techniques were used to elucidate the role of mouse OR23 (MOR23) in regulating the migration and adhesion of differentiated muscle stem cells prior to fusion. In vivo work also suggests that MOR23 regulates the proper regeneration of myofibers. The process of fusion is complex, requiring many receptor-ligand pairs to interact between a differentiated muscle cells and myotubes; these data suggest ORs are important signaling molecules in this system.
My second project focused on the role of chemokine-dependent migration during fusion both in vivo and in vitro. Time-lapse microscopy was used to determine that muscle cells during the process of differentiation and fusion migrate with distinct rates and patterns. Expression patterns from a Real Time RT PCR array suggest that distinct chemokines and chemokine receptors are expressed during differentiation and fusion. Migration experiments determined that CXCR4, the chemokine with the highest steady state levels of mRNA, was necessary for migration of both proliferating muscle cells and terminally differentiated mononucleated muscle cells. Although chemokines are necessary for muscle repair due to their roles in the immune response, these data suggest that chemokines may also regulate muscle cells during differentiation and fusion.Biography:
I joined the Biological Sciences department at Ohio University in August 2012. I teach Principles of Physiology lab, which is great because its my favorite subject. I started physiology work at University of Washington, while earning my B.S. in Zoology. I earned my Ph.D. in Biochemistry, Cell and Developmental Biology at Emory University in the Pavlath lab. While there, I wrote two papers on the role of muscle stem cell migration during skeletal muscle regeneration.Representative Publications: