Selected Publications:


Yanrong Qian, Xuan Wang, Yi Liu, Yunsheng Li, Robert Colvin, Lingying Tong, Shiyong Wu, Xiaozhuo Chen*. Extracellular ATP-induced intracellular ATP increase in cancer cells is mediated by macropinocytosis and contributes to cancer cell survival and drug resistance. Cancer Letter (2014) (Accepted)


Huiwen Cheng, Lei Wang, Molly Mollica, Anthony T. Re, Shiyong Wu*, and Li Zuo*. Nitric oxide in cancer metastasis. (Review) Cancer Letter (2014) (Accepted)


Lingying Tong and Shiyong Wu*. ROS and p53 in Regulation of UVB-induced hdm2 Alternative Splicing. Photochem. & Photobio. (2014) Jul 2. [Epub ahead of print] PubMed


Ye Yuan, Michelle L Duff, Dawn L Sammons*, Shiyong Wu. Retrospective chart review of skin cancer presence in the wide excisions. World J Clin Cases (2014) March 16; 2(3): 52-56. PubMed


Shin Hee Lee, Huiwen Cheng, Ye Yuan, and Shiyong Wu*. Regulation of ionizing radiation-induced adhesion of breast cancer cells to fibronectin by alpha5beta1 integrin. Radiation Research (2014) Jun;181(6):650-8. PubMed


Weiwei Yuan, Xuelin Zhang, Yu Xu, Shasha Li, Yide Hu*, and Shiyong Wu*. Role Of HOXB7 In Regulation Of Progression And Metastasis Of Human Lung Adenocarcinoma. Mol. Carcinogenesis 53:49–57 (2014). PubMed

Oliver L. Carpenter and Shiyong Wu*. Regulation of MSK-1-mediated NF-kB Activation Upon UVB Irradiation. Photochem. & Photobio. (2014). 90: 155-61. PubMed.


Huiwen Cheng, Shin Hee Lee and Shiyong Wu*. Effects Of LNAC On Adhesive Strength Between Breast Cancer Cell and Extracellular Matrix Proteins Upon Ionizing Radiation. Life Sciences (2013) 13;93(21):798-803 PubMed


Ye Yuan, Shin Hee Lee and Shiyong Wu*. The Role Of ROS In Ionizing Radiation-Induced VLA-4 Mediated Adhesion Of RAW264.7 Cells To VCAM-1 Under Flow Conditions. Radiation Research (2013) 179, 62–68. PubMed


Lu W and Wu S*. Mechanism for Dynamic Regulation of iNOS Expression After UVB-Irradiation. Mol. Carcinogenesis (2013) 52(8):627-33. PubMed


Huiwen Cheng, Molly Y. Mollica, Shin Hee Lee, Lei Wang, Carlos A. Velázquez-Martínez* and Shiyong Wu*. Effects of Nitric Oxide-Releasing Nonsteroidal Anti-inflammatory Drugs (NONO-NSAIDs) on Melanoma Cell Adhesion. Toxicol Appl Pharmacol. (2012) Oct 15;264(2):161-6. PubMed


Liu Y, Cao Y, Zhang W, Bergmeier SC, Qian Y, Akbar H, Colvin RA, Ding J, Tong L, Wu S, Hines JV, and Chen X*. A small molecule inhibitor of glucose transporter 1 down-regulates glycolysis, induces cell cycle arrest, and inhibits cancer cell growth in vitro and in vivo.  Mol. Cancer Therapeutics (2012) Aug;11(8):1672-82. PubMed


George KS, Elyassaki W, Wu Q and Wu S*. The Role of Cholesterol In Ultraviolet Light B-Induced Apoptosis. Photochem Photobio (2012) 88: 1191–1197. PubMed


Wu Q and Wu S*. Lipid Rafts Association of Prohibitin And Its Role in Ultraviolet B Light -Induced Apoptosis.  Exp. Dermatology (2012) Aug; 21(8):640-2. PubMed


George KS and Wu S*. Lipid Raft: A Floating Island Of Death or Survival. (Invited Review) Toxicol Appl Pharmacol. (2012) 259(3): 311-319. PubMed


Tong L, Heim RA and Wu S*. Nitric Oxide: A Regulator of Eukaryotic Initiation Factor 2 Kinases. Free Radical Biology & Medicine (2011) 50: 1717–1725. Abstract


Wu S*. Targeting expression or function of Plk1 in CTCL, that is a question. Cell Cycle (2011) 10(10) 1526. PubMed.


Parker TA, Cheng HW, Willeford KO and Wu S*. Interleukin-6 Expression In Response To Innate Immune Regulatory Factor Stimulation. Biomedicine & Pharmacotherapy (2011) 65: 90-94. Abstract


Liu W and Wu S*. The Roles of Akt and NOSs In Regulation of VLA-4-Mediated Melanoma Cell Adhesion To Endothelial VCAM-1 After UVB-irradiation. Archives of Biochemistry and Biophysics (2011) 508: 192-197. Abstract


Wang L, Shirure VS, Burdick MM* and Wu S*. UVB-Irradiation Regulates VLA-4-Mediated Melanoma Cell Adhesion To Endothelial VCAM-1 Under Flow Conditions. Mol. Carcinogenesis (2011) 50(1): 58-65. Abstract


Zimmerman AL and Wu S*. MicroRNAs, Cancer and Cancer Stem Cells. (Review) Cancer Letters (2011) 300: 10-19. Abstract


George KS, Wu Q and Wu S*. Effects Of Freezing And Protein Crosslinker On Isolating Membrane Raft Associated Proteins. BioTechniques (2010) 49(5): 837–838. Abstract. PDF Download.


Wu S*. Localization and function of a eukaryotic-initiation-factor-2-associated 67-kDa glycoprotein. World J. Biol. Chem. (2010) 1(10): 313-320. Abstract. PDF Download.


Liu W and Wu S*. Differential Roles of Nitric Oxide Synthases in Regulation of Ultraviolet B Light-induced Apoptosis. Nitric Oxide-Biology and Chemistry (2010), 23(3): 199-205.  Abstract


Wu S* and Tong L. Differential Signaling Circuits In Regulation Of Ultraviolet C Light-Induced Early- And Late-Phase Activation Of NF-kB. (Invited Review) Photochem Photobio. (2010) 86: 995-999. Abstract


Miao Z., Wu S and Chen H*. The Study of Protein Conformation in Solution via Direct Sampling by Desorption Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom. (2010) 21: 1730-1736. Abstract


Wu S*, Wang L, Jacoby A, Jasinski K, Kubant R and Malinski T. Ultraviolet B Light-Induced Nitric Oxide/Peroxynitrite Imbalance in Keratinocytes – Implication in Apoptosis and Necrosis. Photochem Photobio. (2010) 86: 389-396. Abstract.


Wang L, Liu W, Parker SH, and Wu S*. Nitric oxide synthase activation and oxidative stress, but not intracellular zinc dyshomeostasis, regulate ultraviolet B light-induced apoptosis. Life Sciences (2010) 86: 448-454. Abstract.


Wu S* and Carpenter O. L. Coordinative And Dynamic Regulation Of Translation And Transcription By Nitric Oxide And Superoxide Upon Ultraviolet Light Irradiation. Chapter 14 In: Photobiology: Principles, Applications and Effects. Editor: Leon N. Collignon and Claud B. Normand. Nova Science Publishers, Inc. (2010) 251-267. PDF Download


Liu Y, Laszlo CF, Liu Y, Liu W, Chen X, Evans SC and Wu S*. Regulation of G1 Arrest and Apoptosis under Hypoxia by PERK and GCN2-mediated eIF2a Phosphorylation. Neoplasia (2010) 12(1): 61-68. Abstract. PDF Download.


Wang L, Liu Y and Wu S*. The Roles of Nitric Oxide Synthase and eIF2alpha Kinases in Regulation of Cell Cycle Upon UVB-irradiation. Cell Cycle (2010) 9(1): 38-43. Abstract.


Wu S*. New Life for an _Old_ Drink. Cell Cycle (2009) 8(13): 1979-80. View.


Lu W, Laszlo CF, Miao Z, Chen H and Wu S*. The Role of Nitric Oxide Synthase in Regulation of Ultraviolet Light-induced Phosphorylation of the Alpha-subunit of Eukaryotic Initiation Factor 2. J. Biol. Chem. (2009) 284(36): 24281-24288. Abstract.


Laszlo CF, Fayads S, George KS, Carpenter OL, Lu W, Saad AA and Wu S*. _The Roles Of Translation Regulation In Ultraviolet Light-Induced COX 2 Expression_. Life Sciences (2009) 85: 70-76. Abstract.


Laszlo CF and Wu S*. Old Target New Approach: Translation Inhibition an Alternate NF-kappaB Activation Pathway. Mol Cell Biochem. (2009) 328:9–16. Abstract.


Laszlo CF and Wu S*. Mechanism of UV-Induced IkappaBalpha-Independent Activation of NF-kappaB. Photochem Photobio. (2008) 84: 1564–1568. Abstract.


Parker SH, Parker TA, George KS and Wu S*. The Roles Of Translation Initiation Regulation In Ultraviolet Light-Induced Apoptosis. Mol Cell Biochem. (2006) 293(1-2): 173-81. Abstract.


Elyassaki W. and Wu, S*. _Lipidrafts mediates ultra-violet light-induced FAS aggregation in M624 melanoma cells_. Photochem. & Photobio. (2006) 82: 787-792. Abstract.


Parker TA, Willeford KO, Pharr GT, Hebert P, Pruett SB and Wu S * (2005) An Innate Immune Regulatory Factor (IIRF) Prevents Tumorogenesis in a Murine Melanoma Challenge Model. Drug Dev. Res. 2005; 64:213-219. Abstract.


Wu, S.*, Tan, M., Hu, Y., Wang, J. Scheuner, D. and Kaufman, R. J. (2004). Ultraviolet light induces early-phase NFkB activation through translational inhibition of IkB synthesis J. Biol. Chem. 279(33):34898-34902. Abstract.


Wu, S. and Kaufman, R. J.* (2004). Trans-autophosphorylation of PKR in the Absence of dsRNA is not Sufficient for PKR Dimerization or Activation. Biochemistry 43(34):11027-34. Abstract.


Wu, S.,* Hu, Y., Wang, J., Chatterjee, M., Shi, Y. and Kaufman, R. J. (2002) Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum. J. Biol. Chem. 277, 18077-18083. Abstract.


Wu, S., Loke, H. N. and Rehemtulla, A* (2002) Ultraviolet Radiation-Induced Apoptosis Is Mediated by Daxx. Neoplasia 4, 486-492. Abstract.


Chatterjee, M. and Wu, S.* (2001). Involvement of Fas receptor and not tumor necrosis factor-alpha receptor in ultraviolet-induced activation of acid sphingomyelinase. Mol. Carcinogenesis. 30, 47-55. Abstract.


Chatterjee, M. and Wu, S.* (2001). Cell Line Dependent Involvement Of Ceramide In Ultraviolet Light-Induced Apoptosis. Mol. Cell. Biochem. 219, 21-27. Abstract.


Wang, J., Sun, Y., and Wu, S.* (2000). Gamma-irradiation Induces Matrix Metalloproteinase II (MMP 2) Expression in a p53 Dependent Manner. Mol. Carcinogenesis. 4, 252-258. Abstract.


Wu, S., Kumar, K. U. and Kaufman, R. J.* (1998). Identification and importance of the ribosome binding domains of the dsRNA-dependent Protein Kinase (PKR). Biochemistry 29, 13816-13826. Abstract.


Wu, S. and Kaufman, R. J.* (1997). A Model for the Double-stranded (ds) RNA-Dependent Dimerization and Activation of the dsRNA-dependent Protein Kinase (PKR). J. Biol. Chem. 272, 1291-1296. Abstract.


Wu, S. and Kaufman, R. J.* (1996). Double-stranded RNA Binding Is Repuired And Dimeriaztion Is Not Sufficient for the Activation of the dsRNA-dependent Protein Kinase (PKR). J. Biol. Chem. 271, 1756-1763. Abstract.


Wu, S., Rehemtulla, A., Gupta, N. K. and Kaufman, R. J.* (1996). An eIF-2 Associated 67 kDa Glycoprotein (p67) Partially Reverses Protein Synthesis Inhibition by Activated Double-stranded RNA Depentdent Protein Kinase (PKR) in Intact Cells. Biochem. 35, 8275-8250. Abstract.