Mathematical Modeling and Scale-up of Liquid Chromatography


A book written by Tingyue Gu, Dept. of Chemical Engineering, Ohio University
Published by Springer Verlag, Berlin-New York, 1995. (ISBN 3-540-58884-1)
Available from Amazon.com and other book dealers. Currently out of print. Springer will start printing again only after they accumulate enough back orders. 

2nd edition is being written. This edition will add cored beads and ion-exchange. Detailed application examples will be given. It will be publish in late 2014 or early 2015.

Corrections are listed below.

Abstract

Liquid chromatography is no longer limited to chemical analysis. It has become an indispensable tool for the preparative- and large-scale purifications of proteins and other fine chemicals. So far, the scale-up of liquid chromatography relies mostly on trial and error and a few scaling rules that are more of a rule-of-thumb nature.

This book provides numerical solutions to a series of general multicomponent rate models for liquid chromatography. The models consider dispersion, interfacial film mass transfer, intraparticle diffusion, and nonlinear multicomponent isotherm, or the second order kinetics. The models can be used to simulate various chromatographic operations. They provide more realistic descriptions of preparative- and large-scale liquid chromatography than the equilibrium theory and plate models because various mass transfer mechanisms are included.

The applications of the Fortran 77 codes for the models are explained. Parameter estimation for the models is discussed. The codes should be helpful in both the understanding of the dynamics of liquid chromatography and its scale-up. The codes are available to readers upon request by a letter, or preferably an electronic mail.

August 1994
Tingyue Gu
 

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Corrections:
On p. 14,  in Eq. (3-24), [AKBi] should be [AKBi][cbi].
On p. 27, in the middle, "However, for the column inlet" should be "However, for the column exit"
On p. 33, in Table 4.1, the two 10's for eta should both be 5. Bed voidage and particle porosity should both be 0.45, not 0.4.
On p. 83, in Table 8.1, Cinf for Figures 8.1 and 8.2 should be 3, not 0.3.
 

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