Computational Models of Fatigue Damage in Bone, and Mechanotransduction

Bone injuries can occur due to trauma, and failure and damage can occur from repetitive use. At its most basic level, bone physiology and response to injury and wear is determined by the forces and stresses exerted on the bone. Understanding the relationship between the mechanical factors and damage provides insights into ways to minimize musculoskeletal problems and develop prosthetic devices. John R. Cotton, assistant professor of mechanical engineering, combines finite element methods with mechanical engineering analysis to develop computational models of fatigue damage and biological response in bone. He uses these models to analyze clinical injuries, repair techniques, and the design of biomechanical implants. In a related area, Cotton’s group has been successful in modeling the mechanotransduction of receptor cells in the inner ear. He plans to conduct similar research into simulating mechanoreceptors within bone.