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Stephen Bergmeier

Professor, Chemistry and Biochemistry
Biomedical Engineering
CLIP 277
bergmeis@ohio.edu
Phone: 740.597.9649

http://www.ohio.edu/chemistry/faculty/bergmeier.php


Research Interests: Drug Design, Drug Synthesis, Pharmaceutical Engineering

All Degrees Earned: Ph.D., Medicinal Chemistry, University of Michigan, 1990.

Journal Article, Academic Journal (24)

  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. Simple Modifications to Methimazole That Enhance its Anti-inflammatory Activity. European Journal of Pharmacology.
  • Malki, A., Laha, R., Bergmeier, S. Synthesis and cytotoxic activity of MOM-ether analogs of isosteviol. Elsevier; 24: 1184-1187.
  • Zhou, S., Means, J., Acquaah-Harrison, G., Bergmeier, S., Hines, J. 1. Characterization of a 1,4-disubstituted 1,2,3-triazole binding to T box antiterminator RNA . Bioorganic and Medicinal Chemistry; 20: 1298-1302.
  • Fang, F., Roberts, D., Zhou, S., Hines, J., Bergmeier, S. 2. A synthesis of 1,4-disubstituted Imidazolidin-2-ones from fused-ring aziridines I.W. Maciagiewicz. Synthesis; 44: 551-560.
  • Fang, F., Vogel, M., Hines, J., Bergmeier, S. 3. Fused ring aziridines as a facile entry into triazole fused tricyclic and bicyclic heterocycles . Org. Biomol. Chemistry; 10: 3080-3091.
  • Liu, Y., Cao, Y., Zhang, W., Bergmeier, S., Qin, Y., Akbar, H., Colvin, R., Ding, J., Tong, L., Wu, S., Hines, J., Chen, X. 4. A small molecule inhibitor of glucose transporter 1 (Glut1) down-regulates glycolysis, induces cell cycle arrest, and inhibits cancer cell growth in vitro and in vivo . Mol. Cancer Ther; 11: 1672-1682.
  • Bergmeier, S., Wells, G., Huang, J., Katz, S. Studies on the ring opening reactions of 3-oxa-1-azabicyclo[3.1.0]hexan-2-ones. Synthesis of aminomethyl oxazolidinones and aziridinyl ureas. Tetrahedron; 68: 3980-39887.
  • Bergmeier, S. 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors. Bioorganic and Medicinal Chemistry Letters; 22: 1797-1813.
  • Bergmeier, S., Huang, J. An improved synthesis of functionalized cis-dicahydroquinolines using a Baylis- Hillman-type adduct. Heterocycles; 84: 1289-1299.
  • Hurst, W., Krake, S., Bergmeier, S., Payne, M., Miller, K., Stuart, D. Impact of fermentation, drying, roasting and Dutch processing on flavan-3-ol stereochemistry in cacao beans and cocoa ingredients. . Chemistry Central Journal; 5.
  • Bergmeier, S., McMills, M. Synthesis of a functionalized oxabicyclo[2.2.1]-heptene-based chemical library. . Combinatorial Chemistry and High-Througput Synthesis; 15: 81-89.
  • Sumskaya, Y., Swain, P., Bergmeier, S., McMills, M., Priestley, N., Wright, D. Natural feedstocks for diversity-oriented synthesis: macrolide-like scaffolds from nonactate. Arkivoc; 144-166. http://://WOS:000290685400013.
  • Zhou, S., Acquaah-Harrison, G., Bergmeier, S., Hines, J. Anisotropy studies of tRNA-T box antiterminator RNA complex in the presence of 1,4-disubstituted 1,2,3-triazoles. . Bioorganic and Medicinal Chemistry; 21: 7059-7063.
  • Orac, C., Zhou, S., Means, J., Boehm, D., Bergmeier, S., Hines, J. Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA. 6786-6795. Journal of Medicinal Chemistry; 54.
  • Henderson, B., Orac, C., Maciagiewicz, I., Bergmeier, S., McKay, D. 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors. . Bioorganic and Medicinal Chemistry Letters; 21: 1797-1813.
  • Maciagiewicz, I., Zhou, S., Bergmeier, S., Hines, J. Structure activity studies of RNA-binding oxazolidinone derivatives. . Bioorganic and Medicinal Chemistry Letters; 21: 4524-4527.
  • Phillips, J., Smith, A., Kusche, B., Bessette, B., Swain, P., Bergmeier, S., McMills, M., Wright, D., Priestley, N. Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. 19. Bioorganic & Medicinal Chemistry Letters; 20: 5936-5938. http://://WOS:000281735600073.
  • Bergmeier, S., Liu, Y., Cao, Y., Zhang, W., Chen, X. Small compound inhibitors of basal glucose transport inhibit cell proliferation and induce apoptosis in cancer cells via glucose-deprivation-like mechanisms. . Cancer Lett.; 298: 176-185.
  • Bergmeier, S., Krake, S. Inter- and intramolecular reactions of epoxides and aziridines with pi-nucleophiles. . 37. Tetrahedron; 66: 7337-7360.
  • Bergmeier, S., Hines, J., Zhou, S., Acquaah-Harrison, G. A library of 1,4-disubstituted 1,2,3-triazole analogs of oxazolidinone RNA-binding agents. . 4. J. Comb. Chem. ; 12: 491-496.
  • Bergmeier, S., Orac, C. Negative Allosteric Modulators that Target Human α4β2 Neuronal Nicotinic Receptors. . J. Pharmaco. Exp. Ther. ; 334: 761-774.
  • Bergmeier, S., Zhang, W., Chen, X., Liu, Y. Novel inhibitors of basal glucose transport as potential anticancer agents. Bioorg Med Chem Lett. ; 20: 2191-2194.
  • Luesse, S., Wells, G., Nayek, A., Smith, A., Kusche, B., Bergmeier, S., McMills, M., Priestley, N., Wright, D. Natural products in parallel synthesis: Triazole libraries of nonactic acid. 14. Bioorganic & Medicinal Chemistry Letters; 18: 3946-3949. http://://WOS:000257640400025.
  • Nikodinovic, J., Dinges, J., Bergmeier, S., McMills, M., Wright, D., Priestley, N. Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions. 3. Organic Letters; 8: 443-445. http://://WOS:000235120700023.

Book, Chapter in Scholarly Book (3)

  • Bergmeier, S., , . Three-membered ring systems. Elsevier; 25: 47-70.
  • Bergmeier, S., , . Three-membered ring systems. Progress in Heterocyclic Chemistry; 23: 75-100.
  • Bergmeier, S., Lapinsky, D. Three-membered ring systems. . Progress in Heterocyclic Chemistry; 22: 59-83.

Journal Article, Professional Journal (1)

  • McMills, M., Bergmeier, S. Natural Prtoduct Derivatives with Bactericidal Activity Against Gram-positive Pathogens Including Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecalis. 19. Bioorganic and Medicinal Chemistry Letters/Elsevier; 20: 5936-5938.

Patents

  • Goetz, D., Bergmeier, S., McMills, M., Orac, C., McCall, K., Schwartz, F. Imidazole and thiazole compositions for modifying biological signaling.
  • Goetz, D., Bergmeier, S., McCall, K., Schwartz, F., Deosarkar, S., Bhatt, P. Methods and compositions to modify GSK-3 activity.
  • Bergmeier, S., Goetz, D., McMall, K. A method to modify the activity of GSK-3.
  • Bergmeier, S., Goetz, D., McMall, K. Use of phenylmethyimazole for the prevention and treatment of fatty liver disease.
  • Bergmeier, S., Goetz, D., McMills, M., McMall, K. Compositions that modify biological signaling.