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Jennifer Hines

Professor
Biomedical Engineering
Biochemistry Research Facility 116
hinesj@ohio.edu
Phone: 740.593.9464

http://www.ohio.edu/chemistry/faculty/hines.php


Research Interests: RNA Drug Discovery, AIDS, Bacterial Infections, Cancer

All Degrees Earned: Ph.D., Medicinal Chemistry, University of Michigan, 1991.

Journal Article, Academic Journal (8)

  • Zhou, S., Means, J., Acquaah-Harrison, G., Bergmeier, S., Hines, J. 1. Characterization of a 1,4-disubstituted 1,2,3-triazole binding to T box antiterminator RNA . Bioorganic and Medicinal Chemistry; 20: 1298-1302.
  • Fang, F., Roberts, D., Zhou, S., Hines, J., Bergmeier, S. 2. A synthesis of 1,4-disubstituted Imidazolidin-2-ones from fused-ring aziridines I.W. Maciagiewicz. Synthesis; 44: 551-560.
  • Fang, F., Vogel, M., Hines, J., Bergmeier, S. 3. Fused ring aziridines as a facile entry into triazole fused tricyclic and bicyclic heterocycles . Org. Biomol. Chemistry; 10: 3080-3091.
  • Liu, Y., Cao, Y., Zhang, W., Bergmeier, S., Qin, Y., Akbar, H., Colvin, R., Ding, J., Tong, L., Wu, S., Hines, J., Chen, X. 4. A small molecule inhibitor of glucose transporter 1 (Glut1) down-regulates glycolysis, induces cell cycle arrest, and inhibits cancer cell growth in vitro and in vivo . Mol. Cancer Ther; 11: 1672-1682.
  • Zhou, S., Acquaah-Harrison, G., Bergmeier, S., Hines, J. Anisotropy studies of tRNA-T box antiterminator RNA complex in the presence of 1,4-disubstituted 1,2,3-triazoles. . Bioorganic and Medicinal Chemistry; 21: 7059-7063.
  • Orac, C., Zhou, S., Means, J., Boehm, D., Bergmeier, S., Hines, J. Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA. 6786-6795. Journal of Medicinal Chemistry; 54.
  • Maciagiewicz, I., Zhou, S., Bergmeier, S., Hines, J. Structure activity studies of RNA-binding oxazolidinone derivatives. . Bioorganic and Medicinal Chemistry Letters; 21: 4524-4527.
  • Bergmeier, S., Hines, J., Zhou, S., Acquaah-Harrison, G. A library of 1,4-disubstituted 1,2,3-triazole analogs of oxazolidinone RNA-binding agents. . 4. J. Comb. Chem. ; 12: 491-496.

Book, Chapter in Scholarly Book (3)

  • Anupam, R., Zhou, S., Hines, J. Electrophoretic Mobility Shift Assay of RNA-RNA Complexes. Methods in Molecular Biology Springer Protocols (Humana Press); 1240: 153-164.
  • Zhou, S., Anupam, R., Hines, J. Fluorescence anisotropy: Analysis of tRNA binding to the T box riboswitch anti terminator RNA. Methods in Molecular Biology Springer Protocols (Humana Press); 1240: 143-152.
  • Liu, J., Zeng, C., Zhou, S., Hines, J. Fluorescence assays for monitoring RNA-ligand interactions and riboswitch-targeted drug discovery screening. Methods in Enzymology (Elsevier); 550.