Skip to: Main Content Search Navigation Secondary Navigation

Ohio University’s Athens Campus is closed Thursday, March 5 from 4 a.m. to 10 a.m.; normal operations will resume at 10 a.m. Thursday, March 5.

The morning closure hours are intended to allow employees to make their travel plans to work ... More Information
 

Stephen Bergmeier

Professor, Chemistry and Biochemistry
Biomedical Engineering
CLIP 277
bergmeis@ohio.edu
Phone: 740.597.9649

http://www.ohio.edu/chemistry/faculty/bergmeier.php


Research Interests: Drug Design, Drug Synthesis, Pharmaceutical Engineering

All Degrees Earned: Ph.D., Medicinal Chemistry, University of Michigan, 1990.

Journal Article, Academic Journal (25)

  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. Simple Modifications to Methimazole that Enhance its Inhibitory Effect on Tumor Necrosis Factor-alpha-Induced Vascular Cell Adhesion Molecule-1 Expression by Human Endothelial Cells. European Journal of Pharmacology.
  • Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. Simple Modifications to Methimazole That Enhance its Anti-inflammatory Activity. European Journal of Pharmacology.
  • Malki, A., Laha, R., Bergmeier, S. Synthesis and cytotoxic activity of MOM-ether analogs of isosteviol. Elsevier; 24: 1184-1187.
  • Zhou, S., Means, J., Acquaah-Harrison, G., Bergmeier, S., Hines, J. 1. Characterization of a 1,4-disubstituted 1,2,3-triazole binding to T box antiterminator RNA . Bioorganic and Medicinal Chemistry; 20: 1298-1302.
  • Fang, F., Roberts, D., Zhou, S., Hines, J., Bergmeier, S. 2. A synthesis of 1,4-disubstituted Imidazolidin-2-ones from fused-ring aziridines I.W. Maciagiewicz. Synthesis; 44: 551-560.
  • Fang, F., Vogel, M., Hines, J., Bergmeier, S. 3. Fused ring aziridines as a facile entry into triazole fused tricyclic and bicyclic heterocycles . Org. Biomol. Chemistry; 10: 3080-3091.
  • Liu, Y., Cao, Y., Zhang, W., Bergmeier, S., Qin, Y., Akbar, H., Colvin, R., Ding, J., Tong, L., Wu, S., Hines, J., Chen, X. 4. A small molecule inhibitor of glucose transporter 1 (Glut1) down-regulates glycolysis, induces cell cycle arrest, and inhibits cancer cell growth in vitro and in vivo . Mol. Cancer Ther; 11: 1672-1682.
  • Bergmeier, S., Wells, G., Huang, J., Katz, S. Studies on the ring opening reactions of 3-oxa-1-azabicyclo[3.1.0]hexan-2-ones. Synthesis of aminomethyl oxazolidinones and aziridinyl ureas. Tetrahedron; 68: 3980-39887.
  • Bergmeier, S. 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors. Bioorganic and Medicinal Chemistry Letters; 22: 1797-1813.
  • Bergmeier, S., Huang, J. An improved synthesis of functionalized cis-dicahydroquinolines using a Baylis- Hillman-type adduct. Heterocycles; 84: 1289-1299.
  • Hurst, W., Krake, S., Bergmeier, S., Payne, M., Miller, K., Stuart, D. Impact of fermentation, drying, roasting and Dutch processing on flavan-3-ol stereochemistry in cacao beans and cocoa ingredients. . Chemistry Central Journal; 5.
  • Bergmeier, S., McMills, M. Synthesis of a functionalized oxabicyclo[2.2.1]-heptene-based chemical library. . Combinatorial Chemistry and High-Througput Synthesis; 15: 81-89.
  • Sumskaya, Y., Swain, P., Bergmeier, S., McMills, M., Priestley, N., Wright, D. Natural feedstocks for diversity-oriented synthesis: macrolide-like scaffolds from nonactate. Arkivoc; 144-166. http://://WOS:000290685400013.
  • Zhou, S., Acquaah-Harrison, G., Bergmeier, S., Hines, J. Anisotropy studies of tRNA-T box antiterminator RNA complex in the presence of 1,4-disubstituted 1,2,3-triazoles. . Bioorganic and Medicinal Chemistry; 21: 7059-7063.
  • Orac, C., Zhou, S., Means, J., Boehm, D., Bergmeier, S., Hines, J. Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA. 6786-6795. Journal of Medicinal Chemistry; 54.
  • Henderson, B., Orac, C., Maciagiewicz, I., Bergmeier, S., McKay, D. 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors. . Bioorganic and Medicinal Chemistry Letters; 21: 1797-1813.
  • Maciagiewicz, I., Zhou, S., Bergmeier, S., Hines, J. Structure activity studies of RNA-binding oxazolidinone derivatives. . Bioorganic and Medicinal Chemistry Letters; 21: 4524-4527.
  • Phillips, J., Smith, A., Kusche, B., Bessette, B., Swain, P., Bergmeier, S., McMills, M., Wright, D., Priestley, N. Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. 19. Bioorganic & Medicinal Chemistry Letters; 20: 5936-5938. http://://WOS:000281735600073.
  • Bergmeier, S., Liu, Y., Cao, Y., Zhang, W., Chen, X. Small compound inhibitors of basal glucose transport inhibit cell proliferation and induce apoptosis in cancer cells via glucose-deprivation-like mechanisms. . Cancer Lett.; 298: 176-185.
  • Bergmeier, S., Krake, S. Inter- and intramolecular reactions of epoxides and aziridines with pi-nucleophiles. . 37. Tetrahedron; 66: 7337-7360.
  • Bergmeier, S., Hines, J., Zhou, S., Acquaah-Harrison, G. A library of 1,4-disubstituted 1,2,3-triazole analogs of oxazolidinone RNA-binding agents. . 4. J. Comb. Chem. ; 12: 491-496.
  • Bergmeier, S., Orac, C. Negative Allosteric Modulators that Target Human α4β2 Neuronal Nicotinic Receptors. . J. Pharmaco. Exp. Ther. ; 334: 761-774.
  • Bergmeier, S., Zhang, W., Chen, X., Liu, Y. Novel inhibitors of basal glucose transport as potential anticancer agents. Bioorg Med Chem Lett. ; 20: 2191-2194.
  • Luesse, S., Wells, G., Nayek, A., Smith, A., Kusche, B., Bergmeier, S., McMills, M., Priestley, N., Wright, D. Natural products in parallel synthesis: Triazole libraries of nonactic acid. 14. Bioorganic & Medicinal Chemistry Letters; 18: 3946-3949. http://://WOS:000257640400025.
  • Nikodinovic, J., Dinges, J., Bergmeier, S., McMills, M., Wright, D., Priestley, N. Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions. 3. Organic Letters; 8: 443-445. http://://WOS:000235120700023.

Book, Chapter in Scholarly Book (3)

  • Bergmeier, S., , . Three-membered ring systems. Elsevier; 25: 47-70.
  • Bergmeier, S., , . Three-membered ring systems. Progress in Heterocyclic Chemistry; 23: 75-100.
  • Bergmeier, S., Lapinsky, D. Three-membered ring systems. . Progress in Heterocyclic Chemistry; 22: 59-83.

Journal Article, Professional Journal (1)

  • McMills, M., Bergmeier, S. Natural Prtoduct Derivatives with Bactericidal Activity Against Gram-positive Pathogens Including Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecalis. 19. Bioorganic and Medicinal Chemistry Letters/Elsevier; 20: 5936-5938.

Patents

  • Goetz, D., Bergmeier, S., McMills, M., Orac, C., McCall, K., Schwartz, F. Imidazole and thiazole compositions for modifying biological signaling.
  • Goetz, D., Bergmeier, S., McCall, K., Schwartz, F., Deosarkar, S., Bhatt, P. Methods and compositions to modify GSK-3 activity.
  • Bergmeier, S., Goetz, D., McMall, K. A method to modify the activity of GSK-3.
  • Bergmeier, S., Goetz, D., McMall, K. Use of phenylmethyimazole for the prevention and treatment of fatty liver disease.
  • Bergmeier, S., Goetz, D., McMills, M., McMall, K. Compositions that modify biological signaling.