The first project that I am involved is deals with the development of animal model of environmentally-induced heritable genetic and epigenetic differences that can be transmitted from father to offspring. The significance of proposed project is to establish a mouse model for parental transgenerational transmission of epigenetic modifications resulting from diet-induced obesity, which will alter offspring to predispose to obesity and metabolic disease, and may result in new therapeutic strategies.

The second project related to investigation of the effect of antioxidant-fortified diet on kidney function using Zucker rat model of diabetic nephropathy. The long-term goal of this project is to understand mechanisms involved in diabetic nephropathy and to provide better treatment.

Selected Publications

• Slyvka Y., Nowak F.V., Hayes T.M., and Inman S.R. 2013 Short-term antioxidant diet prevents hyperfiltration in young male rat kidney subjected to ischemia/reperfusion injury Open Journal of Molecular and Integrative Physiology (in press)

• Slyvka Y., Nowak F. V., Wooten W. Matthew, McCall K. D., Malgor R., Wood A. S. and Inman S. R. "Urate Transporter 1 Protein Levels and Localization in Type 2 Diabetic and Non-Diabetic Zucker Rat Kidneys," Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 1, 2013, pp. 63-68. doi: 10.4236/ojemd.2013.31010.

• Slyvka Y., Wang Z., Yee J., Inman S.R. and Nowak FV. 2011 Antioxidant diet, gender and age affect renal expression of nitric oxide synthases in obese diabetic rats, Nitric Oxide: Biology and Chemistry, 24(1): 50-60.

• Slyvka Y, Inman SR, Malgor R, Jackson EJ, Yee J, Oshogwemoh O, Adame J, Nowak FV. Protective Effects of Antioxidant Fortified Diet on Renal Function and Metabolic Profile in Obese Zucker Rat. Endocrine, 2009: 35(1): 89–100
  

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HCOM-Biomedical Sciences