I am interested in the pathogenesis of a multitude of autoimmune-inflammatory diseases including both type I and type II diabetes, a variety of human cancers (i.e. thyroid, pancreatic, prostate, breast, colon, and malignant melanoma), colitis, toxic shock, and atherosclerosis.  Specifically, my current focus is on Toll-Like Receptors and their involvement in the pathogenesis and progression of the aforementioned diseases.

Complete Curriculum Vitae (PDF)

Selected Publications

• McCall, K.D., Schmerr, M.J., Thuma, J.R., James, C.B.L., Courreges, M.C., Benencia, F., Malgor, R., Schwartz, F.L. (2013) Phenylmethimazole Suppresses dsRNA-Induced Cytotoxicity and inflammatory Cytokines in Murine Pancreatic Beta Cells and Blocks Viral Acceleration of Type 1 Diabetes in NOD Mice. Molecules. 18: 3841-3858, doi:10.3390/molecules18043841.
  

• Slyvka, Y, Nowak, F.V., Wooten, M., McCall, K.D., Malgor, R., Wood, A.S., Inman, S.R. (2013) Urate Transporter 1 (URAT1) Protein Levels and Localization in Type 2 Diabetic and Non-diabetic Zucker Rat Kidneys. Open Journal of Endocrine and Metabolic Diseases.  Accepted. 

• Courreges, M.C., Kantake, N., Goetz, D., Schwartz, F.L., McCall, K.D. (2012) Phenylmethimazole Blocks dsRNA-Induced IRF3 Nuclear Translocation and Homodimerization. Molecules. 17: 12365-12377, doi:10.3390/molecules171012365. 

• Bhatt, P.M, Lewis, C.J., House, D.L., McCall, K.D., Goetz, D.J., Malgor, R. (2012) Oxidized LDL increases Wnt5a mRNA expression in human monocyte-derived macrophages. The Open Circulation & Vascular Journal. 5:1
  
• McCall, K.D., Benencia, F., Malgor, R., Schwartz, A.L., Kohn, L.D., Schwartz, F.L. (2011) Toll-Like Receptors as Novel Therapeutic Targets for the Treatment of Pancreatic Cancer (Book Chapter). Pancreatic Cancer - Molecular Mechanism and Targets, ISBN 978-953-51-0410-0: 361-398.
  

• McCall, K.D., Holliday, D., Dickerson, E., Wallace, B., Schwartz, A., Schwartz, C., Lewis, C.J., Kohn, L.D., Schwartz, F. (2010) Phenylmethimazole Blocks Palmitate-Mediated Induction of Inflammatory Cytokine Pathways in 3T3L1 Adipocytes and RAW264.7 Macrophages. J Endocrinology. 207:
  343-353.

For more publications please link to PubMed.

Awards and Honors

2013    Outstanding Woman in Innovation Award, TechGrowth Ohio

2012    Distinguished Osteopathic Commitment Award for "Outstanding Research Mentor",
             Ohio University Heritage College of Osteopathic Medicine

2011    Nominated for Distinguished Osteopathic Commitment Award,
             Ohio University Heritage College of Osteopathic Medicine

2010    Nominated for Distinguished Osteopathic Commitment Award,
             Ohio University Heritage College of Osteopathic Medicine

Related Links

Heritage College of Osteopathic Medicine
Biomedical Engineering