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Kelly McCall, PhD

Assistant Professor, Specialty Medicine

Biomedical Engineering

Biomedical Sciences, HCOM

mccallk@ohio.edu

Ph.D., 2003, Molecular and Cellular Biology, Ohio University

Complete Curriculum Vitae (PDF)

 

Research Interests

I am interested in the pathogenesis of a multitude of autoimmune-inflammatory diseases including both type I and type II diabetes, a variety of human cancers (i.e. thyroid, pancreatic, prostate, breast, colon, and malignant melanoma), colitis, toxic shock, and atherosclerosis.  Specifically, my current focus is on Toll-Like Receptors and their involvement in the pathogenesis and progression of the aforementioned diseases.

Selected Publications

• McCall, K.D., Benencia, F., Malgor, R., Schwartz, A.L., Kohn, L.D., Schwartz, F.L. (2011) Toll-Like Receptors as Novel Therapeutic Targets for the Treatment of Pancreatic Cancer. Pancreatic Cancer (Book Chapter). Accepted.

• Benavides, U., Gonzalez-Murguiondo, M., Harii, N., Lewis, C.J., Schwartz, A.L., Giuliani, C., Napolitano, G., Dagia, N.M., Malgor, R., McCall, K.D., Kohn, L.D. (2011) Phenylmethimazole Inhibits Production of Pro-Inflammatory Mediators and is Protective in an Experimental Model of Endotoxic Shock. Critical Care Medicine. Accepted.

• McCall, K.D., Holliday, D., Dickerson, E., Wallace, B., Schwartz, A., Schwartz, C., Lewis, C.J., Kohn, L.D., Schwartz, F. (2010) Phenylmethimazole Blocks Palmitate-Mediated Induction of Inflammatory Cytokine Pathways in 3T3L1 Adipocytes and RAW264.7 Macrophages. J Endocrinology. 207: 343-353.

• Schwartz, A, Malgor, R., Dickerson, E., Weeraratna, A., Slominski, A., Wortsman, J.,Harii, N., Kohn, A.D., Moon, R.T., Schwartz, F., Goetz, D., Kohn, L.D., McCall, K.D.(2009) Phenylmethimazole Decreases Toll-Like Receptor-3 and Non-Canonical Wnt5a Expression in Pancreatic Cancer & Melanoma Together with Tumor Cell Growth & Migration. Clinical Cancer Research. 15(12): 4114-4122.

• McCall, K.D., Harii, N., Lewis, C.J., Malgor, R., Kim, W.B., Saji, M., Kohn, A.D., Moon,R.T., Kohn, L.D. (2007) High Basal Levels of Functional Toll-like Receptor 3 (TLR3) and Noncanonical Wnt5a Are Expressed in Papillary Thyroid Cancer (PTC) and Are Coordinately Decreased by Phenylmethimazole Together with Cell Proliferation and Migration. Endocrinology 148(9): 4226-4237.

• Harii, N., Lewis, C.J., Vasko, V., McCall, K., Benavides-Peralta, U., Sun, X., Ringel, M.D., Saji, M., Kohn, L.D. (2005) Thyrocytes express a functional toll-like receptor 3(TLR3): Overexpression can be induced by viral infection and reversed by Phenylmethimizole and is associated with Hashimoto’s Autoimmune Thyroiditis. Molecular Endocrinology 19(5): 1231-1250.