Home>Faculty>Profile

Leslie Consitt, PhD

Assistant Professor, Physiology

Biomedical Sciences, HCOM

consitt@ohio.edu

 

Ph.D., 2005, Exercise Physiology, University of North Carolina

Complete Curriculum Vitae (PDF)

Research Interest

     The overall aim of my research is to investigate the development and treatment of metabolic diseases associated with excess nutritional lipid intake and/or physical inactivity.  I am particularly focused on elucidating the cellular mechanisms controlling skeletal muscle glucose and lipid metabolism and how impairments in these mechanisms contribute to insulin resistance in conditions such as obesity, diabetes, and aging. I use a combination of human, animal, and cell culture models to identify cellular mechanisms that contribute to skeletal muscle insulin resistance and use interventions such as exercise and diet modification to help correct cellular impairments.

 

Selected Publications

• Boyle, K.E., J.P. Canham, L.A. Consitt, D. Zheng, T.R. Koves, T.P. Gavin, D. Holbert, P.D. Neufer, O. Ilkayeva, D.M. Muoio, and J.A. Houmard.  A High-Fat Diet Elicits Differential Responses in Genes Coordinating Oxidative Metabolism in Skeletal Muscle of Lean and Obese Individuals. J Clin Endocrinol Metab. 96(3): 775-81, 2011.
  

• Consitt, L.A., J.A. Bell, M. Hulver, T.R. Koves, D.M. Muoio, G.L. Dohm and J.A. Houmard.  PGC-1α overexpression increases lipid oxidation in myocytes from extremely obese individuals. Diabetes. 59(6): 1407-15, 2010.

• Bell, J.A., M.A. Reed, L.A. Consitt, O.J. Martin, K.R. Haynie, M.W. Hulver, D.M. Muoio, and G.L. Dohm.  Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression.  J Clin Endocrinol Metab. 95(7): 3400-10, 2010.
  

• Consitt, L.A., J.A. Bell, and J.A. Houmard.  Intramuscular Lipid Metabolism, Insulin Action, and Obesity.  IUBMB Life. 61(1): 47-55, 2009.  

• Consitt, LA., L. Wideman, M.S. Hickey, and R.F. Morrison.  Phosphorylation of the JAK2-STAT5 pathway in response to acute aerobic exercise.  Med Sci Sports Exerc. 40(6): 1031-8, 2008.