Multiple Sclerosis (MS) is a central nervous system (CNS) disease where myelin sheathes of the neurons are destroyed by the immune system. This disease is associated with brain tissue damage (e.g. lesions) that can be observed through Magnetic Resonance Imaging (MRI). Since summer 2008, Dr. Jundong Liu of CSCIT's Medical Image Analysis Lab has been collaborating with researchers from the Sanders-Brown Center on Aging at University of Kentucky in using neuroimaging approach to study MS lesions. A matlab-based software package for segmentation of MS lesions has been developed to accurately measure subjects' brain volumes in structures associated with MS pathology. New methods to conduct longitudinal studies on the development of the lesions over time are being explored. The collaborative research has the potential to help us identify the biomarkers of Multiple Sclerosis in the future.