Biochemical Research at Ohio University attempts to unlock the mysteries of living organisms and human disease using state of the art biochemical experimentation. Sophisticated physical, chemical, analytical, genetic and molecular biology techniques are all being employed to solve critical biochemical problems in both animal and plant systems. Current research projects within the division include the mechanisms of carcinogenesis, plant cell wall development, and investigating the structure and assembly of biological motor proteins. In addition, other investigators in the division are researching novel methods for biochemical analysis as well as the development of therapeutic ribonucleic acid molecules and the enzymology of coenzyme B12 dependent enzymes.
Dr. Kenneth Brown's research group uses NMR and x-ray crystallography techniques to understand the enzymology of coenzyme B12 dependent enzymes. Dr. Jennifer Hines' research group is involved in the development of ribonucleic acid molecules, which will be used as the next generation of therapeutics. Members of Dr. Marcia Kieliszweski's laboratory are researching the structure and biological function of plant cell wall proteins. Dr. Tadeusz Malinski's research group is developing sophisticated analytical techniques for the measurement of nitric oxide in a single cell, and Dr. Martin Tuck's laboratory is researching the relationship between biological methylation reactions and the carcinogenesis process.
Each investigator in the Biochemistry division conducts research projects that allow all students - undergraduate, masters or doctoral - hands-on laboratory experience. Recent graduates of Biochemistry at Ohio University have gone on to begin exciting scientific careers in academic, government and industrial environments. Another advantage to the student is that the research groups of the division are relatively small, allowing personal contact with the advisor, a trademark of the Ohio University graduate programs.
The facilities for Biochemistry Research are also impressive and are housed, along with each investigator's laboratory, in a new 15,000 square foot research building that was specially designed for biochemical research. Instrumentation on-site and available to students of the program include 3 superconducting NMR spectrometers, macromolecular modeling computer workstations, DNA and protein sequencing facilities, and a microinjection facility for the production of transgenic animals.