John M. Wetzel   Contact Information Office Location: Clippinger Laboratories Phone Number: 740-698-0420 Fax Number: 740-593-0148 E-Mail Address: wetzelj@ohio.edu   Visiting Assistant Professor Ph.D., The Johns Hopkins University B.S., Ohio University Medicinal Chemistry   Biographical Information Students of Dr. Wetzel can benefit from his 15+ years as an industrial medicinal chemist.  These students can learn from a former pharmaceutical industry manager what kinds of jobs are available in this field and how to  obtain the necessary qualifications to successfully compete for these positions. Dr. Wetzel currently consults for the pharmaceutical industry.  His previous positions included Director  of Chemistry at Synaptic Pharmaceutical Corporation, where he led a team of chemists engaged in the discovery of drugs for G protein-coupled receptor targets in the central and peripheral nervous systems.  He has guided and/or participated in drug discovery and development projects directed toward new therapies for mood, sleep and urogenital disorders, pain and obesity. He is co-inventor on 18 U.S. patents and co-author of 23 peer-reviewed publications.   Selected Publications and Presentations Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl} -8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists. Konkel, M.J.; Wetzel, J.M.; Cahir, M.; Craig, D.A.; Noble, S.A.; Gluchowski, C. (2005) Journal of Medicinal Chemistry 48(8), 3076-3079. 3-Phenyl-2-indolylcarbohydrazide and their azo analogues as potent antagonists for the GalR3 receptor. Topiwala, U.P.; Chen, H.; Jimenez, H.; Reitman, M.; Wetzel, J.M.; Walker, M.; Han, K.; Boyle, N.; Caputo, G.; Muske, G.; Konkel, M.J. (2004) Abstracts of Papers, 228th ACS National Meeting, Philadelphia, PA, MEDI-030. Discovery of SNAP 7941 and analogs as high affinity MCH-1 antagonists. Marzabadi, M.R.; DeLeon, J.; Daniewska, I.; Jiang, Y.; Lagu, B.; Li, B.; Wang, Z.; Forray, C.; Borowsky, B.; Ogozalek, K.; Lichtblau, H.; Lim, K.; Tian, D.; Gluchowski, C.; Noble, S.A.; Wetzel, J.M. (2002) Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, August 18-22, MEDI-340. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. Bonini, J.A.; Jones, K.A.; Adham, N.; Forray, C.; Artymyshyn, R.; Durkin, M.M.; Smith, K.E.; Tamm, J.A.; Boteju, L.W.; Lakhlani, P.P.; Raddatz, R.; Yao, W.-J.; Ogozalek, K.L.; Boyle, N.; Kouranova, E.V.; Quan, Y.; Vaysse, P.J.; Wetzel, J.M.; Branchek, T.A.; Gerald, C.; Borowsky, B. (2000) Journal of Biological Chemistry 275(50), 39324-39331. Determination of the relative and absolute stereochemistry of a potent and α1A-selective adrenoceptor antagonist. Lagu, B.; Wetzel, J.M.; Forray, C.; Patane, M.A.; Bock, M.G. (2000) Bioorganic & Medicinal Chemistry Letters 10(24), 2705-2707. De novo design of a novel oxazolidinone analogue as a potent and selective α1A adrenergic receptor antagonist with high oral bioavailability. Lagu,B.; Tian, D.; Jeon, Y.; Li, C.; Wetzel, J.M.; Nagarathnam, D.; Shen, Q.; Forray, C.; Chang, R.S.L.; Broten, T.P.; Ransom, R.W.; Chan, T.-B.; O'Malley, S.S.; Schorn, T.W.; Rodrigues, A.D.; Kassahun, K.; Pettibone, D.J.; Freidinger, R.; Gluchowski, C. (2000) Journal of Medicinal Chemistry 43(15), 2775-2778

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